Anti-cyclic citrullinated peptide-2 (CCP2) autoantibodies and extra-articular manifestations in Greek patients with rheumatoid arthritis

Alexiou, Ioannis; Germenis, Anastasios E.; Κουτρούμπας, Αθανάσιος; Kontogianni, Anastasia; Theodoridou, Katerina; Sakkas, Lazaros I.

doi:10.1007/s10067-007-0800-1

Cited by 80 publications

(58 citation statements)

References 17 publications

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“…Two main ACPAs are recognised, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) antibodies. Both are markers of disease severity in rheumatoid arthritis [15,16] and there is some suggestion that they occur more in extra-articular disease [17], particularly lung disease [18]. We reasoned that pulmonary citrullination might be a relevant process generating autoantibodies in COPD, alongside elastin liberation.…”

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confidence: 99%

Smoke exposure as a determinant of autoantibody titre in 1-antitrypsin deficiency and COPD

Wood¹,

Pablo²,

Buckley³

et al. 2010

European Respiratory Journal

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Liberation of elastin peptides from damaged lung may be a mechanism of autoimmune lung disease. Citrullination, and anti-citrullinated protein antibody formation occurs in smokers, but the role of smoking in autoantibody generation relevant to pulmonary disease is unclear.Anti-elastin, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) antibodies were measured in 257 subjects with a 1 -antitrypsin deficiency (AATD), 113 subjects with usual chronic obstructive pulmonary disease (COPD) and 22 healthy nonsmokers. Levels were compared between groups, against phenotypic features and against smoke exposure.Anti-elastin antibodies were higher in controls relative to AATD (p50.008) and usual COPD (p,0.00001), and in AATD relative to usual COPD (p,0.00001). Anti-elastin levels showed a threshold at 10 pack-yrs, being higher in those who had smoked less (p50.004). No relationships between antibody levels and clinical phenotype were seen after adjustment for smoke exposure. Anti-CCP antibodies were higher in usual COPD than AATD (p50.002) but the relationship to smoke exposure was less clear.Smoke exposure is the main determinant of anti-elastin antibody levels, which fall after 10 packyrs. Local antibody complexes may be a better measure of elastin directed autoimmunity than circulating levels.KEYWORDS: a 1 -Antitrypsin deficiency, autoimmune disease, chronic obstructive pulmonary disease, smoking and health T he protease-antiprotease hypothesis of the pathogenesis of chronic obstructive pulmonary disease (COPD) concerns imbalances between proteases that digest elastin and other components of the extracellular matrix in the lung parenchyma, and antiproteases that protect [1][2]. The origin of this theory comes from the observation that patients with a 1 -antitrypsin deficiency (AATD) develop early onset emphysema [3]. a 1 -Antitrypsin (AAT) is an antiprotease, which acts predominantly to block the action of neutrophil elastase, a protease released by neutrophils. Neutrophil elastase is a serine protease, the first of three classes of protease important in COPD. The remaining two classes are the cysteine proteases, such as cathepsin-B, and the matrix metalloproteases (MMPs) [4]. In general, the serine and cysteine proteases are capable of degrading elastin and some forms of collagen [4], whilst MMPs have more of an effect on collagen, gelatin and laminin [2], all of which are components of the extracellular matrix of the lung.Breakdown of the extracellular matrix, particularly elastin, in the lung is a key feature of both COPD and AATD, as shown by the presence of high levels of elastin breakdown products. A desmosine cross-link is unique to elastin and may be used as a marker of its degradation [5]. Desmosine and elastin peptides are elevated in the plasma, urine and sputum of COPD patients [6], whilst urinary levels positively correlate with the annual rate of decline in forced expiratory volume in 1 s (FEV1) in smokers [7]. In general, elastin breakdown is greater i...

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confidence: 99%

Smoke exposure as a determinant of autoantibody titre in 1-antitrypsin deficiency and COPD

Wood¹,

Pablo²,

Buckley³

et al. 2010

European Respiratory Journal

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“…15,38 The association of RF and extraarticular disease in RA is well known -the RF is considered a predictor of ExRA. The infl uence of each isotype in that association has been the object of recent studies.…”

Section: Discussionmentioning

confidence: 99%

“…In 2007, Turesson et al 5 reported that anti-CCP was positive in 77% of the patients with ExRAs, while a Greek study has reported 65.3% of that association. 38 The presence of anti-CCP in patients with RA indicates more severe joint disease. The presence of citrullinated proteins in infl amed synovia suggests that they play an important role in the pathogenesis of RA.…”

Section: Discussionmentioning

confidence: 99%

Perfil dos pacientes com manifestações extra-articulares de artrite reumatoide de um serviço ambulatorial em Curitiba, Sul do Brasil

Moura¹,

Zakszewski²,

Silva³

et al. 2012

Rev. Bras. Reumatol.

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Objectives: To describe the epidemiological profi le of patients with extra-articular manifestations of rheumatoid arthritis (ExRA) from an university-affi liated rheumatology center; to report the prevalence of ExRA and to compare it with available data; and to identify, if possible, ExRA predictors. Methods: This study reviewed 262 medical charts of patients previously diagnosed with rheumatoid arthritis (RA) according to the 1987 American College of Rheumatology criteria, and attending that rheumatology center in 2010. The statistical analysis comprised simple mathematical calculations, Student t and chi-square tests, and a signifi cance level of 5% (α = 0.05). Results: During the course of the disease, 120 patients (45.8%) had ExRA. Pulmonary manifestation, rheumatoid nodules and Sjögren's syndrome were the most common manifestations found. Rheumatoid factor and anti-cyclic citrullinated peptide antibody were positive in most patients tested. Most patients were classifi ed as Steinbrocker functional classes 1 and 2. The mean DAS-28 was 3.629, and the mean HAQ score, 1.12. Patients with ExRA had longer disease duration (P < 0.05), and current smoking habit associated with the presence of ExRA (P < 0.05). Conclusions: The prevalence of ExRA during disease course was 45.8%, and current smoking habit correlated with the presence of ExRA.

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“…. Связь между риском развития ИПЛ-РА и высо-ким уровнем РФ была подтверждена и в других исследова-ниях [37,55]. Данные о влиянии АЦЦП на развитие ИПЛ являются противоречивыми [56][57][58].…”

Section: ги с т о л о г и ч е с к а я и к л и н и ч е с к а я к л а сunclassified

Interstitial lung involvement in rheumatoid arthritis

Бестаев¹,

Bestaeva²

2014

RJTAO

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Ревматоидный артрит (РА) -системное аутоиммунное ревматическое заболевание неизвестной этиологии, для ко-торого характерны хронический эрозивный артрит и внесу-ставные проявления [1][2][3][4][5][6][7][8]. Поражение легких -одно из ча-стых внесуставных проявлений РА, которое может про-являться патологией бронхиального дерева, ревматоидны-

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Anti-cyclic citrullinated peptide-2 (CCP2) autoantibodies and extra-articular manifestations in Greek patients with rheumatoid arthritis

Cited by 80 publications

References 17 publications

Smoke exposure as a determinant of autoantibody titre in 1-antitrypsin deficiency and COPD

Smoke exposure as a determinant of autoantibody titre in 1-antitrypsin deficiency and COPD

Perfil dos pacientes com manifestações extra-articulares de artrite reumatoide de um serviço ambulatorial em Curitiba, Sul do Brasil

Interstitial lung involvement in rheumatoid arthritis

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