Anti-Collapsing Response-Mediating Protein-5 Antibody–Positive Paraneoplastic Perioptic Neuritis without Typical Neurological Symptoms

Igarashi, Nozomi; Sawamura, Hiromasa; Kaburaki, Toshikatsu; Aihara, Makoto

doi:10.1080/01658107.2016.1241283

Cited by 13 publications

(7 citation statements)

References 21 publications

(33 reference statements)

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“…MOG-AD-associated optic neuritis more commonly has radiologic features of an optic perineuritis with contrast enhancement of the optic nerve sheath and surrounding orbital fat, as seen in the cases we presented (6,8). Apart from being uncommon in demyelinating disorders other than MOG-AD, perineural enhancement can be an important clue to the presence of an optic neuropathy associated with systemic connective tissue disorders such as sarcoidosis, infection, or paraneoplastic disease (9–11). These pathologies may otherwise have clinical and imaging features that are not substantially different from demyelinating ON.…”

Section: Discussionmentioning

confidence: 99%

Orbital Inflammation in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Case Report and Review of the Literature

Liou¹,

Yoon²,

Maher³

et al. 2022

Journal of Neuro-Ophthalmology

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Background:To present 2 patients with myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease with unilateral orbital inflammation, optic nerve head edema, and abnormalities of the optic nerve and nerve sheath on imaging. We review the most current literature on this important and uncommon clinical phenotype.Methods:A case report of 2 patients and a comprehensive review of the relevant literature on orbital inflammation in MOG antibody–associated disease (MOG-AD).Results:Two patients presented with decreased vision and unilateral orbital inflammation. Both had optic nerve head edema and abnormalities of the optic nerve and nerve sheath on imaging. The patients were treated with immunosuppressants and had improvement of vision changes as well as their orbital inflammatory signs. MOG antibody was positive in high titers in both patients. Only 3 other cases of orbital inflammation associated with MOG antibody have been described. In all cases, orbital signs responded rapidly to intravenous methylprednisolone, but the improvement in visual acuity was variable and less robust.Conclusion:Orbital inflammation is a unique and underrecognized phenotype of MOG-AD with only a few reports in the literature. In patients who present with vision loss and orbital inflammation, MOG-AD should be considered in the differential.

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Section: Discussionmentioning

confidence: 99%

Orbital Inflammation in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Case Report and Review of the Literature

Liou¹,

Yoon²,

Maher³

et al. 2022

Journal of Neuro-Ophthalmology

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“…The pain and worsening vision are so bothersome that almost no one wants to see if it improves spontaneously; patients tend to find their way to an ophthalmologist very early in the course of the disease. Pain when moving the eyes is absent in 8% of patients whose inflammatory focus is located in the intracranial portion of the optic nerve and, therefore, proximal to its mobile portion [14].…”

Section: Optic Neuritis Clinicmentioning

confidence: 99%

"Demyelinating and Autoimmune Optic Neuritis: Approach and Management"

Sánchez

2023

OAJBS

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Background: A healthy optic nerve is a crucial conduit for impulses generated within the layers of the retina to leave the eye. To date, the mechanism of action of optic neuritis is not entirely clear, as are the therapeutic approaches, especially in the pediatric population. To date it is estimated that the annual incidence of optic neuritis is estimated between 0.56 and 5.1 cases per 100,000 people.Methodology: A systematic review was carried out through various databases from January 2015 to September 2022; The search and selection of articles were carried out in indexed journals in English. Results:The first clinical manifestation that we can find in a patient with optic neuritis is a pain when moving the eyes, with subsequent worsening of vision. Only 0.4% of patients develop symptoms in both eyes simultaneously. Intravenous methylprednisolone at 1000 mg/day has been found to lead to more rapid recovery of vision. IV immunoglobulin and plasma exchange are used in patients refractory to initial treatment. Erythropoietin has demonstrated neuroprotective properties. Conclusion:This review offers updated and detailed information that helps the health professional in clinical practice, to identify the main clinical symptoms and thus prevent and treat said pathology promptly.

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“…37 Brain MRI findings can be normal, 38 reveal contrast enhancement of the nerve 39 or contrast enhancement of its surrounding meninges. 40 Visual loss is usually associated with central or peripheral neurological symptoms (e.g. nystagmus, dementia, ataxia, and polyneuropathy).…”

Section: Atypical On Nmosd (Aqp4+ and Aqp4−)mentioning

confidence: 99%

Optic neuritis classification in 2021

Ducloyer¹,

Marignier

Wiertlewski³

et al. 2021

European Journal of Ophthalmology

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Optic neuritis (ON) can be associated with inflammatory disease of the central nervous system or can be isolated, with or without relapse. It can also be associated with infectious or systemic disease. These multiple associations based on a variety of clinical, radiological, and biological criteria that have changed over time have led to overlapping phenotypes: a single ON case can be classified in several ways simultaneously or over time. As early, intensive treatment is often required, its diagnosis should be rapid and precise. In this review, we present the current state of knowledge about diagnostic criteria for ON aetiologies in adults and children, we discuss overlapping phenotypes, and we propose a homogeneous classification scheme. Even if distinctions between typical and atypical ON are relevant, their phenotypes are largely overlapping, and clinical criteria are neither sensitive enough, nor specific enough, to assure a diagnosis. For initial cases of ON, clinicians should perform contrast enhanced MRI of the brain and orbits, cerebral spinal fluid analysis, and biological analyses to exclude secondary infectious or inflammatory ON. Systematic screening for MOG-IgG and AQP4-IgG IgG is recommended in children but is still a matter of debate in adults. Early recognition of neuromyelitis optica spectrum disorder, MOG-IgG-associated disorder, and chronic relapsing idiopathic optic neuritis is required, as these diagnoses require therapies for relapse prevention that are different from those used to treat multiple sclerosis.

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Anti-Collapsing Response-Mediating Protein-5 Antibody–Positive Paraneoplastic Perioptic Neuritis without Typical Neurological Symptoms

Cited by 13 publications

References 21 publications

Orbital Inflammation in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Case Report and Review of the Literature

Orbital Inflammation in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Case Report and Review of the Literature

"Demyelinating and Autoimmune Optic Neuritis: Approach and Management"

Optic neuritis classification in 2021

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