Anti‐caries effect of a 2% Na<sub>2</sub>PO<sub>3</sub>F‐dentifrice in a Danish fluoride area

Lind, O. P.; Fehr, F.R. von der; Larsen, Mona; Møller, I.J.

doi:10.1111/j.1600-0528.1976.tb00961.x

Cited by 15 publications

(3 citation statements)

References 7 publications

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“…using sodium monofluorophosphate dentifrice reported a 30% reduction in dental caries increments and 27.9% and 28.2% reduction in DMFT and DMFS values, respectively. [ 16 ] The results of the study are in accordance with the results reported by Leo Hanachowicz, Lind and Anlow.…”

Section: Discussionsupporting

confidence: 91%

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

Damle¹,

Deoyani²,

Bhattal³

et al. 2012

Dent Res J

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Background:The efficacy of fluoridated dentifrices in caries prevention has been well documented and research into various formulations continues for a more effective dentifrice. This study evaluated the anti-caries and anti-plaque efficacy of a dentifrice containing sodium monofluorophosphate (1000 ppm) and calcium glycerophosphate, and compared it with a non-fluoridated dentifrice.Materials and Methods:A total of 595 school children (12–15 years) were divided into test (302 children) and control (293 children) groups. The test group used the dentifrice containing sodium monofluorophosphate (1000 ppm) and calcium glycerophosphate, whereas the control group was given a placebo dentifrice. Oral examination for dental caries and plaque assessment was carried out at the start of the study and the children were followed up semiannually up to 18 months. Data were analyzed using repeated-measure analysis of variance (ANOVA) followed by one-way ANOVA.Results:The values for decayed missing filled teeth (DMFT) increased from baseline to 18 month examination from 4.43±2.03 and 4.67±2.25 (P=0.175) to 5.84±2.29 and 5.13±2.30 (P=0.001) for control and test groups, respectively. Similarly, the increase in decayed missing filled surface (DMFS) values were from 6.42±4.10 and 7.06±4.77 (P=0.082) to 8.64±4.51 and 7.92±5.07 (P=0.095) for test and control groups, respectively. The mean DMFT and DMFS values increased for both the groups; however, the increase was less in test group as compared to control group. The baseline plaque score reduced from 2.94±0.72 and 2.91±0.72 (P=0.679), respectively, for control and test groups to 1.33±0.46 and 0.91±0.38 (P<0.001), respectively, at 18 month examination.Conclusion:Results revealed that the test dentifrice was effective in inhibiting the progression of plaque and control of dental caries as compared to the placebo dentifrice.

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Section: Discussionsupporting

confidence: 91%

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

Damle¹,

Deoyani²,

Bhattal³

et al. 2012

Dent Res J

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“…The concentration of fluoride in dentifrices tested most frequently in clinical trials has been 1,000 parts per million (ppm), usually as sodium monofluorophosphate (MFP). Many studies have been done with higher than conventional concentrations of fluoride, r a n p g from 1,450 to 2,800 pprn of fluoride (41)(42)(43)(44)(45)(46)(47). Ripa (47) recently reviewed these studies.…”

Section: Effectiveness Of Toothpastes With Lower-thanconventional Flumentioning

confidence: 99%

The Need for Toothpastes with Lower than Conventional Fluoride Concentrations for Preschool‐aged Children

Horowitz¹

1992

J Public Health Dent

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Since 1945, when community water fluoridation was first implemented in the United States, not only has the procedure grown to cover more than half of the US population, but the development and use of other fluoride methods have expanded greatly. A concomitant, dramatic decrease has occurred in the caries prevalence of US school-aged children. Recent studies indicate, however, that the prevalence and, to a lesser extent, the intensity of dental fluorosis have increased in schoolchildren in both fluoridated and fluoride-deficient areas. Several studies show that young children inadvertently ingest sizable proportions of toothpaste during toothbrushing. Although ingestion of fluoride toothpastes by preschool-aged children may not be the major contributor to the increase in fluorosis, the findings of at least four studies suggest that the use of fluoride toothpastes by young children is a risk factor. The direct dose-response relation between effectiveness and fluoride concentration of toothpastes is far from clear-cut and, at best, is weak. Thus, considering today's reduced risk of caries, it is timely to market fluoride toothpastes in the US with 400-500 ppm fluoride for preschool-aged children, who are still at risk for developing fluorosis, as has been done in several other countries. Dental public health authorities must work with toothpaste manufacturers, professional organizations, and regulatory agencies to facilitate the approval and marketing of such pediatric fluoride toothpastes.

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“…Currently marketed over-the-counter fluoride dentifrices contain about 1000 ppm fluoride. Studies have generally shown positive results when evaluating the higher fiuoride dentifrices (2)(3)(4)(5)(6)(7)(8)(9). Higher concentrations of fiuoride delivered from other vehicles, such as topical gels and solutions, have produced excellent results in the prevention of caries but are available only by prescription.…”

mentioning

confidence: 99%

A 3‐year clinical trial to compare efficacy of dentifrices containing 1.14% and 0.76% sodium monofluorophosphate

Conti

Lotzkar

Daley³

et al. 1988

Comm Dent Oral Epid

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A 3-yr daily supervised toothbrushing study with a double blind design was conducted to evaluate the anticaries effectiveness of a 1.14% sodium monofluorophosphate (MFP) dentifrice (1500 ppm F) compared to a 0.76% MFP dentifrice (1000 ppm F). This study began with nearly 4000 children, primarily aged 8-11, in grades 3-5, residing in a nonfluoridated community in Florida. A total of 2415 children completed 3 yr of the study, representing 61% of the children who began the study. The results indicate a statistically significant (P less than 0.001) anticaries benefit was derived over a 3-yr period from the use of the higher fluoride dentifrice (1500 ppm F) when compared to the positive control (1000 ppm F). Percent reductions in mean dental caries increments were 20.9%, 22.1%, 21.8%, 24.3%, and 35.2% for DMFT, DFT, DMFS, DFS, and DFS Interproximal, respectively.

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Anti‐caries effect of a 2% Na₂PO₃F‐dentifrice in a Danish fluoride area

Cited by 15 publications

References 7 publications

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

The Need for Toothpastes with Lower than Conventional Fluoride Concentrations for Preschool‐aged Children

A 3‐year clinical trial to compare efficacy of dentifrices containing 1.14% and 0.76% sodium monofluorophosphate

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Anti‐caries effect of a 2% Na2PO3F‐dentifrice in a Danish fluoride area

Cited by 15 publications

References 7 publications

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

The Need for Toothpastes with Lower than Conventional Fluoride Concentrations for Preschool‐aged Children

A 3‐year clinical trial to compare efficacy of dentifrices containing 1.14% and 0.76% sodium monofluorophosphate

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Anti‐caries effect of a 2% Na₂PO₃F‐dentifrice in a Danish fluoride area