A 3‐year clinical trial to compare efficacy of dentifrices containing 1.14% and 0.76% sodium monofluorophosphate

Abstract

A 3-yr daily supervised toothbrushing study with a double blind design was conducted to evaluate the anticaries effectiveness of a 1.14% sodium monofluorophosphate (MFP) dentifrice (1500 ppm F) compared to a 0.76% MFP dentifrice (1000 ppm F). This study began with nearly 4000 children, primarily aged 8-11, in grades 3-5, residing in a nonfluoridated community in Florida. A total of 2415 children completed 3 yr of the study, representing 61% of the children who began the study. The results indicate a statistically significant (P less than 0.001) anticaries benefit was derived over a 3-yr period from the use of the higher fluoride dentifrice (1500 ppm F) when compared to the positive control (1000 ppm F). Percent reductions in mean dental caries increments were 20.9%, 22.1%, 21.8%, 24.3%, and 35.2% for DMFT, DFT, DMFS, DFS, and DFS Interproximal, respectively.

A efetividade do dentifrício fluoretado no controle da cárie dental: uma meta-análise

“…O tamanho do efeito global (valor d) foi de -0,17 (Intervalo de Confiança IC 95% -0,22/-0,12). Três estudos confirmaram a hipótese de que maior concentração de flúor garantiria maior efeito, 7,22,25 enquanto os outros dois não confirmaram essa relação, apesar de apresentarem redução na direção esperada. 21,23 O estudo de Ripa et al 27 foi o único onde a direção dos achados foi em direção oposta ao esperado (valor d=+0,01 IC 95% -0,09/+0,1), ou seja, o grupo com menor concentração de flúor apresentou menor incidência de cárie, apresentando-se não homogêneo.…”

Comparison between Evaluation Methods for the Anti-Caries Efficacy of Monofluorophosphate-Containing Dentifrices

“…All the fluoride toothpastes used in this study have anti-caries efficacy as demonstrated in previous caries clinical trials [Conti et al, 1988;Fogels et al, 1988;Stephen et al, 1988]. The dentifrices contained SMFP as the only source of fluoride.…”

“…Several caries clinical trials indicate a significant, caries reduction with increasing fluoride concentra tion in the dentifrice used [Conti et al, 1988;Fogels e al., 1988;Hodge et al, 1980;Reed, 1973]. A recen 3-year study [Stephen et al, 1988] investigated th dose response of dentifrices containing SMFP at fluo ride levels of 1,000, 1,500, and 2,500 pg F/g and con eluded that there was a strong correlation with reduc tion of caries increment and increasing fluoride con tent of dentifrices.…”

Topical Fluoride for Preventing Dental Caries in Children and Adolescents

“…It was the first fluoride salt to be included into dentifrice formula. There is strong scientific evidence that MFP reduce caries development [92][93][94][95][96][97][98][99]. The main advantage of MFP is that it can combined with chalk-based abrasives to produce affordable formulations, whereas NaF required inert abrasives such as silica, which is more expensive to produce than the chalk-based formulations.…”