Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs

Baer‐Dubowska, Wanda; Narożna, Maria; Krajka‐Kuźniak, Violetta

doi:10.3390/molecules26164957

Cited by 21 publications

(15 citation statements)

References 62 publications

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“…Oleanolic acid (OA) is a pentacyclic triterpene (Figure 18) found in nature as a free acid or as the aglycone of triterpenoid saponins, regularly associated with its position isomer, ursolic acid [237,238]. OA can be extracted from edible and medicinal plants, reaching high concentrations in olive leaves (Olea europaea L.) [239]; it exhibits a broad spectrum of pharmacological activities such as antioxidant, anti-cancer, anti-inflammatory, cardioprotective, hepatoprotective, and anti-diabetic [240,241] and also shows a surprisingly significant inhibitory activity against HIV type 1 [242]. The various OA formulations discussed in this section are schematically represented in Figure 19.…”

Section: Oleanolic Acidmentioning

confidence: 99%

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

Milan

Mioc

Prodea

et al. 2022

IJMS

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The last decade has witnessed a sustained increase in the research development of modern-day chemo-therapeutics, especially for those used for high mortality rate pathologies. However, the therapeutic landscape is continuously changing as a result of the currently existing toxic side effects induced by a substantial range of drug classes. One growing research direction driven to mitigate such inconveniences has converged towards the study of natural molecules for their promising therapeutic potential. Triterpenes are one such class of compounds, intensively investigated for their therapeutic versatility. Although the pharmacological effects reported for several representatives of this class has come as a well-deserved encouragement, the pharmacokinetic profile of these molecules has turned out to be an unwelcomed disappointment. Nevertheless, the light at the end of the tunnel arrived with the development of nanotechnology, more specifically, the use of liposomes as drug delivery systems. Liposomes are easily synthesizable phospholipid-based vesicles, with highly tunable surfaces, that have the ability to transport both hydrophilic and lipophilic structures ensuring superior drug bioavailability at the action site as well as an increased selectivity. This study aims to report the results related to the development of different types of liposomes, used as targeted vectors for the delivery of various triterpenes of high pharmacological interest.

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Section: Oleanolic Acidmentioning

confidence: 99%

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

Milan

Mioc

Prodea

et al. 2022

IJMS

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“…Oleanolic acid, a pentacyclic triterpenoid that widely exists in natural products, possesses antitumor, anti-inflammatory, and hepatoprotective activities ( Baer-Dubowska et al, 2021 ; Hosny et al, 2021 ; Zhang et al, 2021 ). Oleanolic acid exerted potent antiviral activity against the ACV-sensitive strain HSV-1/F and three HSV-1 ACVr strains (Blue, 106 and 153).…”

Section: Bioactive Components That Show Anti-herpes Simplex Virus Act...mentioning

confidence: 99%

Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Zhong²,

Xi³

et al. 2022

Front. Microbiol.

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Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.

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“…Development and evaluation of biomodulatory drugs is already ongoing (Lattuada et al;Baer-Dubowska et al, 2021). Dihydrotanshinone, a naturally occurring compound has been presented in the Research Topic as an inhibitor of hepatocellular carcinoma (HCC) growth by suppressing the JAK2/STAT3 pathway.…”

Section: Novel Technical Approaches To Study the Biological Basis Of Anakoinosis For Sustainable Drug Developmentmentioning

confidence: 99%

Editorial: Anakoinosis: An Innovative Anticancer Therapy Targeting the Aberrant Cancer Tissue Homeostasis

2021

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The aim of anakoinosis is "tissue editing," meaning that bioactive, regulatory acting principles are combined to re-establish tissue homeostasis at primary and metastatic tumor sites by communicatively reprogramming tumor tissue and cell recruitment (Heudobler et al., 2019). Pro-anakoinotic therapies combine regulatorily active drugs, even those with poor or no monoactivity, and may positively supplement classic targeted therapies, as exemplified in relapsed or refractory (r/r) classic Hodgkin's lymphoma (cHL) with the successful introduction of a target of rapamycin (mTor) inhibitor (Heudobler et al., 2018a;.This Research Topic highlights differential clinical outcome characteristics in three histologically completely different neoplasia as a response to "tissue editing" when treated either with pro-anakoinotic approaches (in case of r/r cHL and r/r non-small cell lung cancer, NSCLC) or accidentally initiated by severe fungal infection and reduced intensity induction chemotherapy in acute lymphoblastic leukemia (ALL) (Lüke et al.; Lüke et al.; Heudobler et al.). The clinical responses outline the possibility to specifically activate unique tumor tissue dynamics in response to pro-anakoinotic effectors, either by combining differently acting biomodulatory drugs, or associating DNA damage with fungal infection.DNA damage response following "one shot" chemotherapy in ALL seems to serve as a homeostatic trigger in the case of parallel fungal infection, presumably supervising and amplifying immunological response by the innate immune system, thereby preventing both early relapse and persistence of minimal residual disease, as indicated by long-term continuous complete remission in both described ALL cases (Lüke et al.).In r/r NSCLC, explorative studies of the randomized trial provide strong hints that pre-treatment with combined biomodulatory therapy may be the basis for successful consecutive immune checkpoint inhibitor (ICPi) therapy: even though the progression-free survival rate of the biomodulatory treatment arm is significantly inferior to that of the ICPi arm, it, however, exerts tissue modifications that render successive ICPi more efficacious. These results stimulate the hypothesis that the addition of ICPi to the biomodulation could be beneficial (Heudobler et al.).The immune-modulatory acting MEPED schedule for r/r cHL resulted in pivotal outcomes in six cases. Whether a patient is frail and does not respond to reduced standard first-line therapy, or patients are r/r after autologous hematopoietic-stem-cell transplant (autoHSCT), or even allogeneic

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Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs

Cited by 21 publications

References 62 publications

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges

Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Editorial: Anakoinosis: An Innovative Anticancer Therapy Targeting the Aberrant Cancer Tissue Homeostasis

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