Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Xu, Lin; Zhong, Xuanlei; Xi, Zhichao; Li, Yang; Xu, Hong‐Xi

doi:10.3389/fmicb.2022.1025605

Front. Microbiol.

2022

DOI: 10.3389/fmicb.2022.1025605

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Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Lin Xu

Xuanlei Zhong²,

Zhichao Xi³

et al.

Abstract: Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natu… Show more

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Cited by 2 publications

References 83 publications

(90 reference statements)

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Diaporpyrone E, an undescribed α-pyrone from the endophytic fungus Diaporthe sp. CB10100

Peng

Tang

et al. 2023

Natural Product Research

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An undescribed α-pyrone diaporpyrone E (1), and three known nucleotides, 5'-O-acetyl uridine (2), 5'-O-acetyl thymidine (3) and adenine (4), were identified from Diaporthe sp. CB10100, an endophytic fungus isolated from the medicinal plant Sinomenium acutum. The structure of 1 was determined by extensive analysis of its HRMS, 1D and 2D NMR spectroscopic data, as well as electronic circular dichroism calculations and comparison. The in vitro cytotoxic and antibacterial assays of 1 revealed that it has a 30.2 % inhibitory effect on HepG2 cells at 50 μM, while no antibacterial activities against Staphylococcus aureus and Klebsiella pneumoniae at 64 μg/mL.

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Diaporpyrone E, an undescribed α-pyrone from the endophytic fungus Diaporthe sp. CB10100

Peng

Tang

et al. 2023

Natural Product Research

View full text Add to dashboard Cite

show abstract

Antiviral and Cytotoxic Activities of Ilex aquifolium Silver Queen in the Context of Chemical Profiling of Two Ilex Species

Pachura,

Włodarczyk,

Bażanów

et al. 2024

Molecules

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The leaves of Ilex paraguariensis (known as Yerba mate), used as a popular beverage, are a very well-recognized plant material with various biological activities, including analeptic (because of caffeine), anti-obesity (phenolics, saponins), antimicrobial, and antiviral (phenolics, saponins). Here, the chemical compositions of the leaves of two European Ilex species (× meserveae and aquifolium) with three varieties each were investigated. The terpenoid, saponin, and polyphenolic fractions were submitted for LC-MS or GC-MS analysis against a standard Mate leaf. In addition, the aroma profiles of all the species were analysed using HS-SPME-Arrow prior to GC-MS analysis. All fractions were subjected to antiviral and cytotoxic assays. We found 86 compounds in all accessions, with limonene, linalool, and p-cymene being predominant. There were minor similarities between the volatile compositions of the European and South American species. We found ursolic and oleanolic acid to be the main compounds in the terpenoid fraction. Mono-caffeoylquinic acids and di-caffeoylquinic acids were the main constituents of the polar fractions. About 180 compounds from the saponin group were tentatively identified, of which 9 and 3 were selected as distinctive markers for I. meserveae and I. aquifolium, respectively. Based on chemical screening, I. aquifolium Silver Queen was chosen as the source of terpenoid and saponin fractions and polyphenol extracts. The most substantial inhibition of cancer cell growth was observed with saponin in the case of the MCF7 (human breast cancer) cell line, while for LoVo and L929 cell lines (human colorectal cancer and reference mouse fibroblasts), it was slightly weaker. These results should be analysed further as a promising chemoprevention of colorectal and gastrointestinal cancers. Saponin and polyphenolic extracts exhibited similar activities against HSV-1 and HAdV-5, with 4-log reduction in virus titres. This study focuses our attention on a field of potential antiviral formulations derived from European holly.

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Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Cited by 2 publications

References 83 publications

Diaporpyrone E, an undescribed α-pyrone from the endophytic fungus Diaporthe sp. CB10100

Diaporpyrone E, an undescribed α-pyrone from the endophytic fungus Diaporthe sp. CB10100

Antiviral and Cytotoxic Activities of Ilex aquifolium Silver Queen in the Context of Chemical Profiling of Two Ilex Species

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