Anti-cancer Potential of Phyto-alkaloids: A Prospective Review

Khattak, Sumaira; Khan, Haroon

doi:10.2174/1573394712666160617081638

Cited by 19 publications

(14 citation statements)

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“…The lack of efficient anticancer treatments remains a clinical problem [ 1 , 2 ]. Chemotherapy and/or radiotherapy are the main clinical approaches to cancer treatment, yet both have documented adverse effects [ 3 , 4 , 5 , 6 ]. Cancer treatment affects not only rapidly multiplying cancerous cells but also normal body cells (bone marrow, gastrointestinal tract (GIT), and hair follicles); therefore, these treatments may give rise to severe adverse symptoms.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Ahmed

Khan

Aschner

et al. 2020

IJMS

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129

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Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents.

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Section: Introductionmentioning

confidence: 99%

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Ahmed

Khan

Aschner

et al. 2020

IJMS

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129

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“…Many members of the Lamiaceae also produce alkaloids, which is an extremely diverse chemical group based on a ring structure including a nitrogen atom. Many alkaloids are toxic and are used by plants to protect themselves against aggression from other organisms [ 95 , 96 ]. Many such compounds have a strong cytotoxic effect and induce apoptosis through various pathways in different cell lines [ 97 , 98 ].…”

Section: The Lamiaceae Family Plantsmentioning

confidence: 99%

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Sitarek

Merecz-Sadowska

Śliwiński

et al. 2020

Cancers

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It is predicted that 1.8 million new cancer cases will be diagnosed worldwide in 2020; of these, the incidence of lung, colon, breast, and prostate cancers will be 22%, 9%, 7%, and 5%, respectively according to the National Cancer Institute. As the global medical cost of cancer in 2020 will exceed about $150 billion, new approaches and novel alternative chemoprevention molecules are needed. Research indicates that the plants of the Lamiaceae family may offer such potential. The present study reviews selected species from the Lamiaceae and their active compounds that may have the potential to inhibit the growth of lung, breast, prostate, and colon cancer cells; it examines the effects of whole extracts, individual compounds, and essential oils, and it discusses their underlying molecular mechanisms of action. The studied members of the Lamiaceae are sources of crucial phytochemicals that may be important modulators of cancer-related molecular targets and can be used as effective factors to support anti-tumor treatment.

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“…Alkaloids are rated as among the most‐investigated plant secondary metabolites with versatile biological activity (Figure 2) (Amirkia & Heinrich, 2014; Qiu et al, 2014). Recent investigations have pointed out the dynamic role of alkaloids as antibacterial against methicillin‐resistant Staphylococcus aureus (Pervaiz et al, 2016), antidepressant (Pervez, Khan, & Pervaiz, 2016), antioxidant (Rehman & Khan, 2016), anticancer (Khattak & Khan, 2016), antiasthma (Khan, 2015), antiplatelet (Chen et al, 2001), to name a few. Accordingly, alkaloids are emerging as pharmaceutical tools for the treatment of a variety of immune‐activation‐related disorders (Grynkiewicz & Gadzikowska, 2008).…”

Section: Alkaloids With Therapeutic Potentialmentioning

confidence: 99%

“…Capsaicin appeared to mediate its effects through the stimulation of the transient receptor potential vanilloid subfamily 1(TRPV1) (Deng et al, 2016; Gebhardt, von Bohlen und Halbach, Hadler, Harteneck, & Albrecht, 2016). Of natural products, alkaloids are probably the most widely‐studied secondary metabolites (Ain, Khan, Mubarak, & Pervaiz, 2016; Kaleem et al, 2013; Khattak & Khan, 2016; Marya & Khan, 2017; Paterna et al, 2016; Pervaiz et al, 2016; Zafar, Khan, Rauf, Khan, & Lodhi, 2016; Zhang, Yang, & Guo, 2017) with dynamic potential as therapeutic agents from centuries. The review discusses various alkaloids that have shown evidences of responding to autoimmune diseases in preclinical trials.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of alkaloids in autoimmune diseases: Promising candidates for clinical trials

Khan

Ullah

Khattak

et al. 2020

Phytotherapy Research

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Clinical investigations have characterized numerous disorders like autoimmune diseases, affecting the population at a rate of approximately 8–10%. These disorders are characterized by T‐cell and auto‐antibodies responses to self‐molecules by immune system reactivity. Several therapeutic options have been adopted in clinics to combat such diseases, however, most of them are recurring. Thus, the discovery of new effective agents for the treatment of autoimmune diseases is paramount. In this context, natural products might be a useful alternative to the current therapies. Plant alkaloids with their substantial therapeutic history can be particularly interesting candidates for the alleviation of autoimmune ailments. This review encompasses various alkaloids with significant effects against autoimmune diseases in preclinical trials. These results suggest further clinical assessment with respect to autoimmune illnesses. Furthermore, the application of modern technologies such as nanoformulation could be also helpful in the design of more effective therapies and thus further studies are needed to decipher their therapeutic efficacy as well as potential limitations.

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Anti-cancer Potential of Phyto-alkaloids: A Prospective Review

Cited by 19 publications

References 0 publications

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Therapeutic potential of alkaloids in autoimmune diseases: Promising candidates for clinical trials

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