Anti-cancer efficacy of dietary polyphenols is mediated through epigenetic modifications

Wu, Juan; Lai, Ching Shu; Lee, Pei Sheng; Ho, Chi Tang; Liou, Wen Shiung; Wang, Ying Jan; Pan, Min‐Hsiung

doi:10.1016/j.cofs.2016.01.009

Cited by 19 publications

(14 citation statements)

References 35 publications

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“…The diversity among flavonoids calls for further division into subclasses. The most important subclasses include anthocyanins, chalcones, flavanols (catechins), flavanones, flavones, flavonols and isoflavones [5,6,11]. Their main representatives are collected in Figure 3.…”

Section: Sources Of Phenolic Compounds Their Antioxidant and Antimentioning

confidence: 99%

“…Prevention of disease by polyphenols is mainly due to their antioxidative properties, however, reversal of epigenetic changes can have strong effects as well [11]. It has been experimentally confirmed that polyphenols not only prevent various diseases but also impact on the disease propagation, suppress progression and even contribute to the healing process [5,12].…”

Section: Introductionmentioning

confidence: 99%

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Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

et al. 2016

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Abstract:Being secondary plant metabolites, polyphenols represent a large and diverse group of substances abundantly present in a majority of fruits, herbs and vegetables. The current contribution is focused on their bioavailability, antioxidative and anticarcinogenic properties. An overview of extraction methods is also given, with supercritical fluid extraction highlighted as a promising eco-friendly alternative providing exceptional separation and protection from degradation of unstable polyphenols. The protective role of polyphenols against reactive oxygen and nitrogen species, UV light, plant pathogens, parasites and predators results in several beneficial biological activities giving rise to prophylaxis or possibly even to a cure for several prevailing human diseases, especially various cancer types. Omnipresence, specificity of the response and the absence of or low toxicity are crucial advantages of polyphenols as anticancer agents. The main problem represents their low bioavailability and rapid metabolism. One of the promising solutions lies in nanoformulation of polyphenols that prevents their degradation and thus enables significantly higher concentrations to reach the target cells. Another, more practiced, solution is the use of mixtures of various polyphenols that bring synergistic effects, resulting in lowering of the required therapeutic dose and in multitargeted action. The combination of polyphenols with existing drugs and therapies also shows promising results and significantly reduces their toxicity.

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Section: Sources Of Phenolic Compounds Their Antioxidant and Antimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

et al. 2016

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“…In addition, flavonoids are the most abundant polyphenols in our diet according to Abbaszadeh et al (2019). At the same time, human epidemiological studies have demonstrated the potential impacts of dietary polyphenols on prevention of many cancer types (Pandey et al, 2009, Li et al, 2015, Wu et al, 2016, and the overall results from basic science research mostly agree with the potential role of flavonoids in the human diet as protective compounds (Grosso et al, 2007). Herein, to analyze the efficacy of flavonoids in cancer therapy, we examined only Phases II and III clinical trials.…”

Section: Discussionmentioning

confidence: 94%

Flavonoids as anticancer therapies: A systematic review of clinical trials

Bisol

Campos

Lamers

2019

Phytotherapy Research

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Flavonoids have been proposed as potential chemotherapeutic agents because they are toxic against cancer cells but not harmful to healthy cells. This systematic review analyzed flavonoid effectiveness in human cancer chemotherapy. Overall, 22 phase II and 1 phase III clinical trials (PubMed, Scopus, and Web of Science) that used flavonoids as a single agent or combined with other therapeutics against hematopoietic/lymphoid or solid cancer published by January 2019 were selected for analysis. Flavopiridol was the most commonly used flavonoid (at a dose of 50‐mg/m2 IV) for all tumor types. Aside from the relatively low rate of complete response (CR) or partial response (PR) with any administration protocol, flavonoids showed higher positive outcomes for hematopoietic and lymphoid tissues (140 patients with CR and 88 with PR among 615 patients in 11 trials) than for solid tumors (4 patients with CR and 21 with PR among 525 patients in 12 trials). However, because of the high variety in administration schedule, more studies are needed to further understand how flavonoids can promote positive outcomes for cancer patients.

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“…Many studies demonstrate that polyphenolic compounds have different beneficial influences on health such as antiviral, antioxidant, anti‐inflammatory, antithrombogenic, antiallergic, antihyperlipidemic, diabetes, asthma, and anticancer effects (A.‐N. Li et al, ; Scalbert, Manach, Morand, Rémésy, & Jiménez, ; Wu et al, ). Polyphenols have been reported to have in vivo and in vitro antiproliferative effects on various human cancer cells with little or no toxicity effects on normal cells (Ramos, ; Scalbert et al, ).…”

Section: Introductionmentioning

confidence: 99%

A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compounds

Abbaszadeh

Keikhaei

Mottaghi

2019

Phytotherapy Research

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The aim of this review is to obtain a further understanding of the reported inhibitory effects of polyphenols on cancer cell proliferation and angiogenesis process and the probable mechanisms by which these natural compounds inhibit proliferation of cancer cells and angiogenesis. Growing evidence indicates that polyphenols are beneficial against human fatal diseases such as cancer. Because angiogenesis has a critical role in tumor growth and metastasis, therefore, we decided to review the potential anticancer and antiangiogenic activities and molecular mechanisms of different groups of known polyphenolic compounds. As knowledge and data on anticancer and antiangiogenic effects of plant-derived phenols are on the rise, it may be possible in the near future to develop and discover specific polyphenolic compounds with potent anticancer and antiangiogenic activity for treatment of malignant tumors.

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Anti-cancer efficacy of dietary polyphenols is mediated through epigenetic modifications

Cited by 19 publications

References 35 publications

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

Flavonoids as anticancer therapies: A systematic review of clinical trials

A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compounds

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