A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compounds

Abstract

The aim of this review is to obtain a further understanding of the reported inhibitory effects of polyphenols on cancer cell proliferation and angiogenesis process and the probable mechanisms by which these natural compounds inhibit proliferation of cancer cells and angiogenesis. Growing evidence indicates that polyphenols are beneficial against human fatal diseases such as cancer. Because angiogenesis has a critical role in tumor growth and metastasis, therefore, we decided to review the potential anticancer and antiangiogenic activities and molecular mechanisms of different groups of known polyphenolic compounds. As knowledge and data on anticancer and antiangiogenic effects of plant-derived phenols are on the rise, it may be possible in the near future to develop and discover specific polyphenolic compounds with potent anticancer and antiangiogenic activity for treatment of malignant tumors.

Silibinin Inhibit Cell Migration through Downregulation of RAC1 Gene Expression in Highly Metastatic Breast Cancer Cell Line

“…Silibinin is a polyphenolic flavonolignan of slymarin from seeds of milk thistle (Silybum marianum) and multitude published reports proved different anticancer efficacy of silibinin in experimental in vitro and in vivo models. These anticancer properties include apoptosis induction, inhibiting cell proliferation, angiogenesis, and inhibition of invasion in a variety of cancer models [12][13][14]. Silibinin has been revealed to be an effective chemotherapeutic and chemopreventive agent without unwanted side effects and therefore it could have potential clinical application for breast cancer treatment [15].…”

Flavonoids as anticancer therapies: A systematic review of clinical trials

“…The pattern of the primary molecular structure of flavonoids, as well as the substitution of chemical groups in the flavonoid structure, is correlated with their human biological activity and bioavailability (Durazzo et al, 2019). In addition, flavonoids are the most abundant polyphenols in our diet according to Abbaszadeh et al (2019). At the same time, human epidemiological studies have demonstrated the potential impacts of dietary polyphenols on prevention of many cancer types (Pandey et al, 2009, Li et al, 2015, Wu et al, 2016, and the overall results from basic science research mostly agree with the potential role of flavonoids in the human diet as protective compounds (Grosso et al, 2007).…”

“…In addition, epidemiological studies indicated that soybean-based diets may decrease cancer risk (Dong e al., 2011;Yan et al, 2009). Furthermore, Phase I/II clinical trials showed the potential efficacy of this isoflavone as an antimetastatic agent against prostate cancer (Pavese et al, 2014;Abbaszadeh et al, 2019).…”

Multivariate Analysis of Amino Acids and Health Beneficial Properties of Cantaloupe Varieties Grown in Six Locations in the United States

“…Free radical species have been reported to interfere with metabolic processes which lead to various chronic diseases [ 30 , 31 ]. Antioxidants such as phenolics play a crucial role in inhibiting oxidative stress and show a positive association with human health by strengthening immune defenses [ 32 , 33 ]. The antioxidant activity of plants can be determined by using different bioassays such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) [ 34 , 35 ].…”