Anti-Cancer Activity of Catechin against A549 Lung Carcinoma Cells by Induction of Cyclin Kinase Inhibitor p21 and Suppression of Cyclin E1 and P–AKT

Abstract

Catechin is one of the major polyphenols in teas, beans, and berry fruits. A number of studies have confirmed that catechins extract possesses health benefits in the prevention of various chronic diseases. In this study, the anti-cancer activity and mechanism of catechin against non-small cell lung cancer A549 cells were investigated. The inhibitory rate of catechin on the proliferation of A549 cells reached 19.76% at a concentration of 600 µmol·L −1 with 24 h incubation. The results demonstrated that catechin inhibits A549 cells by increasing the expressions of p21 and p27 in the cancer cells. Furthermore, the catechin treatment inhibited the expressions of cyclin E1 and phosphorylation of protein kinase (P-AKT) in a dose-dependent manner, which also contributed to the inhibition of cancer cell proliferation. Therefore, the results of this study indicated that catechin can effectively inhibit the proliferation of A549 cells through regulating its cell cycle arrest or indirectly via the p21 signaling pathway. It would provide important information for developing catechin and catechin-rich functional food or co-therapy for antitumor purposes.

Integrative Network Pharmacology of Moringa oleifera Combined with Gemcitabine against Pancreatic Cancer

“…Since catechin was the only compound that has been recognized as a hub compound in the shared biotargets intersection against pancreatic cancer, this compound plays a vital role against pancreatic cancer. Catechin is one of the flavonoid derivatives, which is prominently found in green tea, that possesses health-promoting properties, including anticancer and antioxidant properties [42][43][44]. It has been demonstrated that catechin, which is also known as cyclooxygenase-1 (COX-1) inhibitor, had exhibited a synergistic and additive antiproliferative effect on breast, bladder, and prostate cancer in vitro with the combination of COX-2 inhibitor [45,46].…”

Exploiting the Potential of Bioactive Molecules Extracted by Ultrasounds from Avocado Peels—Food and Nutraceutical Applications

“…Most of these compounds have a negative effect in various types of cells. For example, the findings of a study conducted by Sun et al [ 68 ] stated that catechins can adequately inhibit growth of A549 cells via regulating its cell cycle arrest or indirectly through the p21 signaling pathway.…”

Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology

“…Caffeic acid has been shown to improve the cytotoxicity of chemotherapeutics in LC cells [ 163 ]. Catechins may suppress the growth and promote cell cycle arrest of LC cells by inactivating proliferation-inducing oncogenic kinases and cell cycle regulators [ 164 , 165 ]. Chrysophanol regulates the activation of oxidative stress responses and relevant signaling pathways to reduce the proliferation, migration, invasion, and survival potential of LC cells [ 166 , 167 ].…”