Anti-C1q antibodies in lupus nephritis and their correlation with the disease activity

George, Emad; Al-Barshomy, Said M

doi:10.4103/1319-2442.284008

Cited by 10 publications

(4 citation statements)

References 28 publications

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“…Though serum autoantibodies (a-C1q, dsDNA) were present at significantly higher levels in paediatric systemic lupus erythematosus (pSLE) patients with proliferative nephritis than those without, 31,32 and we had observed a correlation between LN-III and LN-IV and GMT, although the percentages of LN-III and LN-IV were not different between the two groups. As a result, we concluded that LN typing has no impact on the results.…”

Section: Resultsmentioning

confidence: 57%

Anti‐C1q antibodies in lupus nephritis children with glomerular microthrombosis

et al. 2023

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Aim: Glomerular microthrombosis (GMT) was a common vascular lesion in patients with lupus nephritis (LN). The objective of this study was to investigate the relationship between serum anti-beta2-glycoprotein I antibodies (a-β2GP1) and anticomplement 1q antibodies (a-C1q) antibodies and to investigate the possible mechanism of GMT in children with LN. Methods:The subjects were 191 children with LN diagnosed by renal biopsy in our hospital from January 2017 to January 2020. The patients were divided into GMT group and non-GMT group. The clinical manifestations, laboratory tests, renal pathology, prognosis of the two groups and the relationship between a-β2GP1 and a-C1q antibodies were observed.Results: In 191 children with LN, 52 cases (27.23%) presented with GMT. The value of C3, haemoglobin (Hb), estimate glomerular filtration rate (eGFR) and anticardiolipin antibody (ACA) in GMT group were lower than that of non-GMT group (p < .05, p < .01).The value of serum creatinine (Scr), 24 h proteinuria (PRO), urine red blood cells (RBC), N-acetyl-β-D-glucosidase (NAG) and retinol-binding protein (RBP), a-C1q, a-β2GP1, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and renal histopathological activity index (AI) score in GMT group were higher than that of non-GMT group (p < .05, p < .01). The positive proportions of serum a-C1q and a-β2GP1 in GMT group were higher than those in non-GMT group (p < .05). According to Spearman correlation analysis, a-C1q was positively correlated with AI score, SLEDAI, a-β2GP1, GMT, LN-III and LN-IV. Hb, eGFR and a-C1q Ab were associated with the formation of GMT in children with LN. The complete proteinuria remission and renal survival in GMT group were significantly lower than those in non-GMT group (p < .05, p < .01). Conclusion:LN children with GMT had more severe clinical manifestations and renal pathologic damages, and poor outcome. Serum a-C1q level was positively correlated with a-β2GP1, and a-β2GP1 may be involved in the formation of GMT in children with LN, which might involve in the activation of complement classical pathway.

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Section: Resultsmentioning

confidence: 57%

Anti‐C1q antibodies in lupus nephritis children with glomerular microthrombosis

et al. 2023

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“…Conversely, a negative correlation existed with the chronicity index and, particularly, with glomerular sclerosis and interstitial fibrosis. The strongest correlations of anti-C1qAb with class IV LN and active renal disease were also confirmed in a Chinese cohort of 150 LN patients ( 57 ), in a recent study on 74 LN patients followed for 5 years ( 66 ), and in 75 Egyptian patients ( 67 ).…”

Section: Anti-c1q In Lupus Nephritismentioning

confidence: 64%

Anti-C1q antibodies: a biomarker for diagnosis and management of lupus nephritis. A narrative review

Calatroni,

Moroni,

Conte

et al. 2024

Front. Immunol.

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Nephritis is a frequent and severe complication of Systemic Lupus Erythematous (SLE). The clinical course of lupus nephritis (LN) is usually characterized by alternating phases of remission and exacerbation. Flares of LN can lead to deterioration of kidney function, necessitating timely diagnosis and therapy. The presence of autoantibodies against C1q (anti-C1qAb) in the sera of SLE patients has been reported in various studies. Some research suggests that the presence and changes in the titer of anti-C1qAb may be associated with the development of LN, as well as with LN activity and renal flares. However, the exact role of anti-C1qAb in LN remains a subject of debate. Despite variability in the results of published studies, anti-C1qAb hold promise as noninvasive markers for assessing LN activity in SLE patients. Measuring anti-C1qAb levels could aid in diagnosing and managing LN during periods of both inactive disease and renal flares. Nevertheless, larger controlled trials with standardized laboratory assays are necessary to further establish the utility of anti-C1qAb in predicting the reactivation and remission of LN and guiding treatment strategies.

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“…We also found, the number of sclerotic glomeruli were significantly higher in intensity of 2 and more of C1q. We believe that this issue is due to the relationship between lupus severity and C1q (18,19), which implies further kidney damage. Recently, Shang et al evaluated C1q and its relationship to the lupus activity.…”

Section: Discussionmentioning

confidence: 99%

A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings

2021

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Introduction: Lupus nephritis is one of the important aspects of systemic lupus erythematosus (SLE). Objectives: This study aimed to investigate possible relationship between pathological lesions of lupus nephritis classes and demographic and biochemical findings among patients. Patients and Methods: This is a cross-sectional study that was conducted on a group of renal biopsy proven lupus nephritis patients using lupus nephritis classification of ISN/RPS 2003. We collected demographic data of all patients including age, gender serum creatinine and 24h proteinuria. Results: Data of 101 patients, of whom 78 (77.23%) were females and mean age of 33.54±13.15 years. The mean serum creatinine and proteinuria were 1.54±0.88 mg/dL 2502.5±1495.05 mg/d. Based on our data, IV-G (class IV, diffuse lupus nephritis-global) lupus nephritis class was the most common (39.6%) followed by class III (23.8%). The mean crescent and sclerotic glomeruli were 1.66±3.32 and 2.27±5.32, respectively. In this study, 24 hours proteinuria, serum creatinine, activity percent, chronicity percent, crescent and glomerular sclerosis between genders showed no significant differences (P>0.05). The correlation between plasma creatinine and activity was directly positive and significant (r=0.381, P=0.001). In addition, a significant correlation between C1q deposits and glomerular sclerosis (P=0.031) was detected. Accordingly, a significant correlation between IgG deposits and lupus nephritis classification (P=0.025) was seen. Conclusion: Lupus nephritis of IV-G and III classes of lupus nephritis were most common among patients and higher IgG deposits were observed in patients with IV-G classification. We found a significant correlation between glomerular sclerosis and C1q deposits that could be an indicator of lupus nephritis activity and severity. However, we recommend further studies in this regard.

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Anti-C1q antibodies in lupus nephritis and their correlation with the disease activity

Cited by 10 publications

References 28 publications

Anti‐C1q antibodies in lupus nephritis children with glomerular microthrombosis

Anti‐C1q antibodies in lupus nephritis children with glomerular microthrombosis

Anti-C1q antibodies: a biomarker for diagnosis and management of lupus nephritis. A narrative review

A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings

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