A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings

Abstract

Introduction: Lupus nephritis is one of the important aspects of systemic lupus erythematosus (SLE). Objectives: This study aimed to investigate possible relationship between pathological lesions of lupus nephritis classes and demographic and biochemical findings among patients. Patients and Methods: This is a cross-sectional study that was conducted on a group of renal biopsy proven lupus nephritis patients using lupus nephritis classification of ISN/RPS 2003. We collected demographic data of all patients including age, gender serum creatinine and 24h proteinuria. Results: Data of 101 patients, of whom 78 (77.23%) were females and mean age of 33.54±13.15 years. The mean serum creatinine and proteinuria were 1.54±0.88 mg/dL 2502.5±1495.05 mg/d. Based on our data, IV-G (class IV, diffuse lupus nephritis-global) lupus nephritis class was the most common (39.6%) followed by class III (23.8%). The mean crescent and sclerotic glomeruli were 1.66±3.32 and 2.27±5.32, respectively. In this study, 24 hours proteinuria, serum creatinine, activity percent, chronicity percent, crescent and glomerular sclerosis between genders showed no significant differences (P>0.05). The correlation between plasma creatinine and activity was directly positive and significant (r=0.381, P=0.001). In addition, a significant correlation between C1q deposits and glomerular sclerosis (P=0.031) was detected. Accordingly, a significant correlation between IgG deposits and lupus nephritis classification (P=0.025) was seen. Conclusion: Lupus nephritis of IV-G and III classes of lupus nephritis were most common among patients and higher IgG deposits were observed in patients with IV-G classification. We found a significant correlation between glomerular sclerosis and C1q deposits that could be an indicator of lupus nephritis activity and severity. However, we recommend further studies in this regard.

Lack of differences between morphological variables in age below 40 years versus more than 40 years in lupus nephritis patients

“…This study was extracted from M.D., thesis of Nasrin Tavassoli at this university (Thesis# 399973). The main part of this research was published previously; however, in this paper we only focused on the demographic, some biochemical and morphologic variables of our patients below and over 40 years old, which was not mentioned in our previous publication (16). Additionally, ethical issues (including plagiarism, data fabrication, double publication) have been completely observed by the authors.…”

“…This study is a continuation of the previously published article by the researchers of this report. However, the new analysis was focused on the impact of age on the LN, which was not addressed in the previous study, therefore the details of method and patients' selection was explain in the study by Tavassoli et al (16). For the statistical analysis, here we conducted student t test to analyze the age groups (≤40 and >40 years).…”

Case Report: 18 Year Old Male Patient with Lupus Nephritis

“…On immunology obtained Anti-HIV and HBsAg nonreactive. Inspection on radiologist also done in the form AP chest radiograph with impression cardiomegaly (LV, LA), suspected pulmonary edema, bronchopneumonia, and minimal both lungs pleural effusion [22].…”