Anti-bacterial/fungal and anti-cancer performance of green synthesized Ag nanoparticles using summer savory extract

Abstract

Nowadays, the expansion of nanoparticles as antimicrobial and anticancer agents is one of the most exciting methods for cancer therapy and microbial diseases that can vanquish the problems of drug resistance. In this research, the biosynthesis of silver nanoparticles (AgNPs) was stated using Summer Savory extract. Moreover, these AgNPs by UV-Vis spectroscopy, FTIR, XRD, FESEM, EDX, PSA, and zeta potential analysis were characterized, and by antimicrobial and anti-cancerous performance was evaluated. The maximum absorption peak at 472 nm by UV-Visible spectra confirmed the formation of Ag nanoparticles. The results obtained by FT-IR determined the presence of organic compounds such as amines, alkenes, alcohols, phenols, which performed significant roles in the fixating of these nanoparticles. The results obtained from FESEM, EDX, PSA, and Zeta Potential Analysis revealed that synthesized AgNPs had a hexagonal structure with a size ranging from 10 to 100 nm. The antimicrobial properties of the synthesized AgNPs were examined by Minimum Inhibitory Concentration, Minimum Bactericidal Concentration, and Minimum Fungal Concentration against five microbial strains included Klebsiella pneumonia, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and Saccharomyces cerevisiae. The results demonstrated that biosynthesized AgNPs had the most antimicrobial activity, especially against E. Coli. The anti-cancerous results of these nanoparticles through MTT assay demonstrated exceptional anticancer effects against K-562 and MCF-7 human cancer cell lines with IC50 values 50 and 200 mg/ml, respectively.

Green Synthesis of Magnetic Nanoparticles Using Satureja hortensis Essential Oil toward Superior Antibacterial/Fungal and Anticancer Performance

“…Accordingly, the significant compositions of SH essential oil are truly distributed all over the FeNPs, as O and Fe are the essential elements of these NPs. Herein, the high quantity of Fe ions within these NPs emphasizes the successful synthesis of magnetite NPs with SH essential oil [ 70 ].…”

“…Also, the exact mechanism of anticancer effects of FeNPs is yet unknown. Nevertheless, different hypotheses have been proposed by researchers in this regard, such as induction of apoptosis and cell cycle arrest through the mitochondrial pathway in some cancer cell lines [ 70 , 79 ]. In some other references, the cytotoxicity of FeNPs is related to their size and shape.…”

Preparation and Characterization of Green Fe3 O4 Nanoparticle Using the Aqueous Plant Extract of Gundelia tournefortii L.

“…5), which indicates the presence oxygen and Iron elements in the composition of magnetite nanoparticles (Fe3O4-NPs) prepared from an aqueous plant extract of GT The iron and oxygen atoms in Fe3O4-NPs are stoichiometric to each other, the theoretical and experimental values are in agreement. The presence of a significant amount of iron ions inside these nanoparticles highlights the effective production of Fe3O4-NPs using the plant (Saleh, 2017) (Ahmadi, et al, 2020).…”

Microbial Enzymes Based Technologies for Bioremediation of Pollutions

“…Bacterias, fungus, algae, and plants use in this method. In other words, enzymes of these microorganisms attack the pollutants and convert them to lowrisk pollutants [1,58]. In bioremediation after degradation of pollutions, the society of microorganisms reduced, and the presence of microorganisms don't create more pollutions [4].…”