Anti-bacterial efficacy of bio-fabricated silver nanoparticles of aerial part of Moringa oleifera lam: Rapid green synthesis, In-Vitro and In-Silico screening

Neupane, Netra Prasad; Kushwaha, Amit Kumar; Karn, Abhishek Kumar; Khalilullah, Habibullah; Khan, Mohd Masih Uzzaman; Verma, Amita

doi:10.1016/j.bcab.2021.102229

Cited by 20 publications

(10 citation statements)

References 20 publications

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“…AgNPs are commonly used in a variety of products due to their special activity and application as an antibacterial [92]. AgNPs are often used in electronic biosensing, clothing, cosmetics, sunscreens, and medical devices.…”

Section: Toxicity Of Agnpsmentioning

confidence: 99%

A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

Salnus¹,

Wahab

Arfah

et al. 2022

Indones. J. Chem.

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Nanotechnology explores nanoscale materials that can be used in a wide range of industries such as biotechnology, cosmetics, drug delivery, nanomedicine, and biosensors. Nanoparticles in diverse shapes and sizes can be prepared through physical, chemical, and biological methods. The employment of reducing agents, which will change their form, size range, level of stability, and interaction, is a crucial part thus employing a biological approach is necessary. Chemically generated metal oxide nanoparticles raise considerable issues owing to the usage of hazardous and poisonous chemicals, as well as the potential for conservational impairment. In contrast, the production of silver nanoparticles using the principal method of green synthesis has found a special place in research that is considered more environmentally approachable requiring the use to produce non-toxic nanomaterials. Plants and polymer materials have received a lot of interest in the preparation of nanoparticles since they are renewable and affordable. In this review, we present a comprehensive overview of more ecologically friendly synthesis techniques that use plant extracts to make silver nanoparticles and their application as antibacterial agents, as well as toxicity features based on the shape, size range, and phytochemical mechanism of plants.

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Section: Toxicity Of Agnpsmentioning

confidence: 99%

A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

Salnus¹,

Wahab

Arfah

et al. 2022

Indones. J. Chem.

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“…Moringa oleifera Lamk, a widely distributed botanical species, holds promise as a medicinal plant with global prevalence. Prior studies have demonstrated that the secondary metabolites found in the Moringa oleifera Lamk plant, specifically flavonoids, phenolics, terpenoids, tannins, and saponins [10], exhibit promising properties as agents with potential anticancer, antibacterial, antifungal, anti-inflammatory, antidiabetic, antioxidant, antihypertensive, and hepatoprotective effects [11]. In addition to the moringa plant, the green tea plant (Camellia sinensis) exhibits promising characteristics as an antioxidant, antimutagenic, antitumor, antiviral, and anticoagulant, with potential benefits against heart diseases, blood pressure regulation, cancer prevention, and cholesterol reduction.…”

Section: Introductionmentioning

confidence: 99%

The phytochemical composition of medicinal plants in Indonesia and their potential as antibacterial agents against Salmonella typhi ATCC 13311

Maharani,

Puspawati,

Rukmana

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Several Indonesian medicinal plants are commonly utilized as antibacterial agents, namely moringa (Moringa oleifera Lamk.), green tea (Camellia sinensis), binahong (Anredera cordifolia (Ten.) Steenis), and green meniran (Phyllanthus niruri L.). This investigation aimed to identify the chemical compounds found in plants and their antibacterial activity against Salmonella typhi. The simplicia was extracted by the maceration technique with a solvent of 70% ethanol. Chemical compounds are identified using various chemical reagents. The antibacterial activity test was conducted using the diffusion method. The data were analyzed using a one-way analysis of variance (ANOVA) test. The phytochemical analysis of plant samples revealed the presence of many bioactive compounds such as flavonoids, saponins, tannins, alkaloids, steroids, and phenolics. The antibacterial activity of plant samples against Salmonella typhi has been shown. The average values of the inhibition zones for moringa leaf extract, green tea, binahong, and green meniran were determined to be 20.33 mm, 18.33 mm, 22.67 mm, and 27.00 mm, respectively. The antibacterial activity of green meniran leaf extract is significantly more potent against Salmonella typhi than other plant.

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“…2,3 Silver NPs have emerged as a potential method for battling bacterial resistance with several products intended to treat both acute and persistent wounds by utilizing the antibacterial activity of silver ions. 4 Only a small number of dressings are based on AgNPs, even though many of them claim to be able to keep wounds moist, avoid infection, keep skin in contact with the dressing, and be biocompatible and less-toxic. 5,6 New research suggests that AgNPs can reduce inflammation and hasten wound healing, in addition to killing germs.…”

Section: ■ Introductionmentioning

confidence: 99%

Electron Beam-Supported Fabrication of Biocompatible Silver/iota-Carrageenan for Wound Healing Application

Sana,

Raorane,

Raj

et al. 2024

ACS Appl. Bio Mater.

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Silver nanoparticles (AgNPs) are a potent antibacterial agent, especially when used to treat bacteria that are multidrug resistant. However, it is challenging to eliminate the hazardous reducing agents that remain in AgNPs produced by the conventional chemical reduction process. To overcome these challenges, the presented research demonstrates the fabrication of AgNPs using iota-carrageenan (ι-carra) as a carbohydrate polymer using electron beam (EB) irradiation. Wellcharacterized ι-carra@AgNPs have a face-centered cubic (FCC) structure with spherical morphology and an average size of 26 nm. Herein we explored the approach for fabricating ι-carra@AgNPs that is suitable for scaling up the production of nanoparticles that exhibit excellent water stability. Further, the optimized ι-carra@AgNPs exhibited considerable antibacterial activity of 40% and 30% inhibition when tested with Gramnegative Escherichia coli ATCC 43895 and Gram-positive Staphylococcus aureus (S. aureus) (ATCC 6538), respectively, and low cytotoxicity at 10−50 μg/mL. To establish the potential biomedical application, as proof of the concept, the ι-carra@AgNPs showed significant antibiofilm activity at 20 μg/mL and also showed 95% wound healing abilities at 50 μg/mL compared to the nontreated control groups. Electron beam assisted ι-carra@AgNPs showed significant beneficial effects against specific bacterial strains and may provide a guide for the development of new antibacterial materials for wound dressing for large-scale production for biomedical applications.

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Anti-bacterial efficacy of bio-fabricated silver nanoparticles of aerial part of Moringa oleifera lam: Rapid green synthesis, In-Vitro and In-Silico screening

Cited by 20 publications

References 20 publications

A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

The phytochemical composition of medicinal plants in Indonesia and their potential as antibacterial agents against Salmonella typhi ATCC 13311

Electron Beam-Supported Fabrication of Biocompatible Silver/iota-Carrageenan for Wound Healing Application

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