Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes

In VitroScreening for Antihepatic Steatosis Active Components within Coptidis Rhizoma Alkaloids Extract Using Liver Cell Extraction with HPLC Analysis and a Free Fatty Acid-Induced Hepatic Steatosis HepG2 Cell Assay

“…Previous work has found evidence that berberine affects glucose metabolism, leading to an increase in insulin secretion, suppression of adipogenesis, inhibition of mitochondrial function, and activation of the 5′ adenosine monophosphate-activated protein kinase (AMPK) pathway [25–28]. This antidiabetic and insulin sensitizing effect of berberine has been confirmed in a few relatively small, short-term clinical trials [29].…”

Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response

“…The root of S. baicalensis is one of the primary ingredients in numerous traditional medicines in China, Japan and Korea (28)(29)(30). Studies have reported that traditional herbal formulas containing SR have anti-atherosclerotic activities (31)(32)(33)(34). Ger-Gen-chyn-lian-tang was shown to reduce atherosclerotic progression in an apolipoprotein E -/mouse model (31); in addition, Dahuang Zhechong, in pill form, inhibited VSMC proliferation and reversed the pathological changes observed in the aorta of atherosclerotic rabbit models (32,33).…”

Rhizoma Coptidis: A Potential Cardiovascular Protective Agent

“…For example, a study on the anti-atherosclerotic potential of Ger-Gen-Chyn-Lian-Tang (a traditional mixture which contains berberine as one of its major active components) has demonstrated reduced atherosclerotic lesions and collagen expression within the atheroma plaques in mice. In addition, in vitro work has also shown a reduction in migration of vascular smooth muscle cells, which is significant as pathological migration of these cells represents a key step in the pathogenesis of atherosclerosis (Ho et al, 2012 ).…”