Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response

Kim, Ohn Soon; Seo, Chang‐Seob; Kim, Yeji; Shin, Hyeun‐Kyoo; Ha, Hyekyung

doi:10.3892/mmr.2015.3502

Cited by 22 publications

(12 citation statements)

References 36 publications

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“…Recently, investigations have shown that S. baicalensis has beneficial properties such as anti-oxidative effect [16], and inhibits anti-dinitrophenyl IgE-medicated anaphylactic reactions and compound 48/80-induced histamine release and calcium uptake into rat peritoneal mast cells (RPMC) [1517]. The flavonoids such as baicalein and wogonin isolated from S. baicalensis have also various biological activities such as anti-oxidative, anti-inflammatory and anti-allergic effects [181920212223].…”

Section: Introductionmentioning

confidence: 99%

Baicalein, wogonin, andScutellaria baicalensisethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release

et al. 2017

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Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of baicalein, wogonin, and Scutellaria baicalensis ethanol extract on ovalbumin (OVA)-induced asthma by evaluating Th1/Th2 cytokine levels, histopathologic analysis, and compound 48/80-induced systemic anaphylaxis and mast cell activation, focusing on the histamine release from rat peritoneal mast cells. Baicalein, wogonin, and S. baicalensis ethanol extract also decreased the number of inflammatory cells especially eosinophils and downregulated peribronchial and perivascular inflammation in the lungs of mice challenged by OVA. Baicalein, wogonin, and S. baicalensis ethanol extract significantly reduced the levels of tumor necrosis factor α, interleukin (IL)-1β, IL-4, IL-5 and the production of OVA-specific IgE and IgG1, and upregulated the level of interferon-γ and OVA-specific IgG2a. In addition, oral administration of baicalein, wogonin, and S. baicalensis ethanol extract inhibited compound 48/80-induced systemic anaphylaxis and plasma histamine release in mice. Moreover, baicalein, wogonin, and S. baicalensis ethanol extract suppressed compound 48/80-induced mast cell degranulation and histamine release from rat peritoneal mast cells. Conclusively, baicalein and wogonin as major flavonoids of S. baicalensis may have therapeutic potential for allergic asthma through modulation of Th1/Th2 cytokine imbalance and histamine release from mast cells.

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Section: Introductionmentioning

confidence: 99%

Baicalein, wogonin, andScutellaria baicalensisethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release

et al. 2017

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“…The L. chinense extract has antioxidant function to scavenge the DPPH radicals, intracellular ROS, hydroxyl radicals, and superoxide (25). Scutellariae Radix was shown to reduce the ABTS and DPPH radical formation in a dose dependent manner (26). Therefore, the addition of these two medicinal herbs may have synergic effects and could help to increase antioxidant effects similar or higher than the 50 ppm and 100 ppm of BHA.…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies have suggested that longterm exposure to physiological or psychological stress is associated with the production of oxidative species, which cause accumulation of oxidative damage to bio-molecules (lipids, proteins, and DNA) in the brain, eventually leading to diverse neurodegenerative diseases (26). Many neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, are associated with excessive production of ROS and free radicals (27).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activities of Functional Beverage Concentrates Containing Herbal Medicine Extracts

Park

Kim

et al. 2017

JFN

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This study investigated the antioxidant activity of functional beverage concentrates containing herbal medicine extracts (FBCH) using various antioxidant assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity, and reducing power assay. The total polyphenolic content of FBCH (81.45 mg/100 g) was higher than Ssanghwa tea (SHT, 37.56 mg/100 g). The antioxidant activities of FBCH showed 52.92% DPPH and 55.18% ABTS radical scavenging activities at 100 mg/mL, respectively. FBCH showed significantly higher antioxidant activities compared to the SHT (DPPH, 23.43%; ABTS, 22.21%; reducing power optical density; 0.23, P<0.05). In addition, intracellular reactive oxygen species generation significantly decreased in a concentration-dependent manner following FBCH treatment. These results suggest that the addition of herbal medicine extract contributes to the improved functionality of beverage concentrates.

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“…GHX02 was formed by adding Scutellariae Radix to GRHRH. GRHRH already demonstrated its anti-inflammatory effects on COPD and particulate matter induced lung injury on a mouse model 16) and previous studies reported that Scutellariae Radix inhibits the production of several inflammatory cytokines 18) and has antioxidant effects 19) .…”

Section: Introductionmentioning

confidence: 94%

Effects of GHX02 on Chronic Obstructive Pulmonary Disease Mouse Model

et al. 2018

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Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and irreversible airflow. This study aimed to evaluate the effects of GHX02 in a COPD-induced mouse model. Methods: The COPD mouse model was established by exposure to cigarette smoke extract and lipopolysaccharide which were administered by intratracheal injection three times with a 7 day interval. GHX02 (100, 200, 400 mg/kg) and all other drugs were orally administrated for 14 days from Day 7 to Day 21. Results: GHX02 significantly decreased the neutrophil counts in bronchoalveolar lavage fluid (BALF) and the number of CD4 + , CD8 + , CD69 + , and CD11b + /GR1 + cells in BALF and lung cells. GHX02 also suppressed the secretion of tumor necrosis factor-alpha (TNF-α), interleukin-17A, macrophage inflammatory protein 2 (MIP2), and chemokine (C-X-C motif) ligand 1 (CXCL-1) in BALF and ameliorated the lung pathological changes. Conclusions: Thus, GHX02 effectively inhibited airway inflammation by inhibiting migration of inflammatory cells and expression of pro-inflammatory cytokines. Therefore, GHX02 may be a promising therapeutic agent for COPD.

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Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response

Cited by 22 publications

References 36 publications

Baicalein, wogonin, andScutellaria baicalensisethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release

Baicalein, wogonin, andScutellaria baicalensisethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release

Antioxidant Activities of Functional Beverage Concentrates Containing Herbal Medicine Extracts

Effects of GHX02 on Chronic Obstructive Pulmonary Disease Mouse Model

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