Anti‐asthmatic and anxiolytic effects of <i>Herissantia tiubae</i>, a Brazilian medicinal plant

Monteiro, Talissa Mozzini; Costa, Hermann Ferrera; Vieira, Giciane Carvalho; Salgado, Paula Regina Rodrigues; Salvadori, Mirian Graciela da Silva Stiebbe; Almeida, Reinaldo Nóbrega de; Souza, María de Fátima Vanderlei de; Matias, Wemerson Neves; Braga, Valdir A.; Nalivaiko, Eugene; Piuvezam, Márcia Regina

doi:10.1002/iid3.107

Cited by 4 publications

(6 citation statements)

References 39 publications

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“…Suncus murinus had a respiratory frequency of ~243 bpm and a tidal volume of ~0.47 ml. These values are at least twice as high as reported for mice (~20 g) (Mitzner et al, 2001 ; Mozzini Monteiro et al, 2016 ). Body temperature (measured subcutaneously) was ~35°C and GMA was typified by a DF of 15 cpm, with 44% of the percentage power being in the normogastric range, which is consistent with our previous studies (Percie du Sert et al, 2010 ).…”

Section: Discussionsupporting

confidence: 58%

Brain Activation by H1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew)

Dieser

et al. 2017

Front. Physiol.

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Motion sickness occurs under a variety of circumstances and is common in the general population. It is usually associated with changes in gastric motility, and hypothermia, which are argued to be surrogate markers for nausea; there are also reports that respiratory function is affected. As laboratory rodents are incapable of vomiting, Suncus murinus was used to model motion sickness and to investigate changes in gastric myoelectric activity (GMA) and temperature homeostasis using radiotelemetry, whilst also simultaneously investigating changes in respiratory function using whole body plethysmography. The anti-emetic potential of the highly selective histamine H1 receptor antagonists, mepyramine (brain penetrant), and cetirizine (non-brain penetrant), along with the muscarinic receptor antagonist, scopolamine, were investigated in the present study. On isolated ileal segments from Suncus murinus, both mepyramine and cetirizine non-competitively antagonized the contractile action of histamine with pKb values of 7.5 and 8.4, respectively; scopolamine competitively antagonized the contractile action of acetylcholine with pA2 of 9.5. In responding animals, motion (1 Hz, 4 cm horizontal displacement, 10 min) increased the percentage of the power of bradygastria, and decreased the percentage power of normogastria whilst also causing hypothermia. Animals also exhibited an increase in respiratory rate and a reduction in tidal volume. Mepyramine (50 mg/kg, i.p.) and scopolamine (10 mg/kg, i.p.), but not cetirizine (10 mg/kg, i.p.), significantly antagonized motion-induced emesis but did not reverse the motion-induced disruptions of GMA, or hypothermia, or effects on respiration. Burst analysis of plethysmographic-derived waveforms showed mepyramine also had increased the inter-retch+vomit frequency, and emetic episode duration. Immunohistochemistry demonstrated that motion alone did not induce c-fos expression in the brain. Paradoxically, mepyramine increased c-fos in brain areas regulating emesis control, and caused hypothermia; it also appeared to cause sedation and reduced the dominant frequency of slow waves. In conclusion, motion-induced emesis was associated with a disruption of GMA, respiration, and hypothermia. Mepyramine was a more efficacious anti-emetic than cetirizine, suggesting an important role of centrally-located H1 receptors. The ability of mepyramine to elevate c-fos provides a new perspective on how H1 receptors are involved in mechanisms of emesis control.

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Section: Discussionsupporting

confidence: 58%

Brain Activation by H1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew)

Dieser

et al. 2017

Front. Physiol.

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“…Glucocorticoids bind to the cytoplasmic glucocorticoid receptor (GR) that dimerizes and translocates to the nucleus and binds to specific glucocorticoid response elements (GRE) 1 . Synthetic glucocorticoids such as prednisone, prednisolone, methylprednisone acetate and dexamethasone are used widely for treatment of inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis 2 . Treatment, especially at higher doses, is however associated with significant adverse side effects including osteoporosis 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone Down-regulates Osteocalcin in Bone Cells through Leptin Pathway

Chen¹,

Peng²,

Wang³

et al. 2018

Int. J. Med. Sci.

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Glucocorticoid therapy, especially at higher doses, is associated with significant adverse side effects including osteoporosis. Leptin, secreted from adipose tissue, has diverse effects on bone tissue regulation. As glucocorticoids stimulate leptin synthesis and secretion directly in adipose tissue we hypothesised that dexamethasone (DEX) induced osteoporosis may, in part, be mediated by an osteoblast dependent leptin-leptin receptor pathway. Human bone cells expressed leptin and leptin receptors (Ob-Ra and Ob-Rb). DEX increased leptin, Ob-Ra and Ob-Rb expression in a dose-dependent manner while decreasing expression of osteocalcin. In the presence of leptin, Cbfa1 and osteonectin expression showed no significant change, whereas osteocalcin expression was decreased. Recombinant human quadruple antagonist leptin suppressed DEX-induced osteocalcin downregulation. The signaling pathway involved up-regulation of JAK2. In conclusion, upregulation of leptin and Ob-Rb in human bone cells by DEX is associated with down-regulation of osteocalcin expression. The down regulation of osteocalcin by DEX was partially through a leptin autocrine/paracrine loop. Adverse effects of DEX on the skeleton may be modified by targeting leptin signaling pathways.

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“…↓ IL-13 and IgE. Mozzini et al 39 S. xanthocarpum 50, 100** and 200 mg/kg, P.O., 22 days Wistar rats OVA (40 mg) + 2 mg Al(OH) 3, in normal saline (Day 0, i.p.). 14 days after immunisation, aerosolised with 1% OVA for 8 consecutive days via nebuliser.…”

Section: Anti-asthmatic Potential Of Tmps Against Ova-induced Asthma In Animalsmentioning

confidence: 99%

“… Aerial parts Ethanol Kaempherol Treatment for fever and respiratory diseases. Mozzini et al; 39 Falcão‐Silva et al 97 S. xanthocarpum Solanaceae It is mainly found in India. Whole plant Water Alkaloids, phenolics, flavonoids, sterol, saponins and glycosides.…”

Section: Anti-asthmatic Potential Of Tmps Against Ova-induced Asthma In Animalsmentioning

confidence: 99%

“…Suppression of inflammation was as efficient as that for dexamethasone. 39 The effects of aqueous extract of Solanum xanthocarpum (S. xanthocarpum) on respiratory tract inflammation and oxidative stress in experimental asthmatic rats were assessed by Gulati. 40 The administration of S. xanthocarpum extract (50 mg/kg), reduced the levels of blood and BALF OVA-specific IgE in Ova-immunised rats by 37% and 20%, respectively.…”

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Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review

Azman

Sekar

Bonam

et al. 2021

JAA

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Asthma is a chronic inflammatory disease of the respiratory tract in which the numerous immune cells, including eosinophils, neutrophils, macrophages, T-lymphocytes, mast cells and epithelial lining play key roles. The numerous anti-asthmatic drugs are available in modern medicine to treat asthma, but they have several disadvantages, including side effects and the cost variations, which compromise treatment compliance. The literature review reveals that traditional herbal medicines have good potential as alternative treatment and management for asthma. However, communities hesitated to use the traditional herbal medicines due to lack of established mechanism of action about their anti-asthmatic potential. The present review aimed to summarise the information stated in the literature about the potential effect of traditional medicinal plants (TMPs) conferring protection against ovalbumin (OVA)-induced asthma model. The literature search was conducted in database like PubMed, Scopus, Google Scholar and ScienceDirect. After screening through the literature from 2011 to date, a total of 27 medicinal plants and two polyherbal extracts have been reported to be used as traditional herbal medicines and also utilised to be tested against OVAinduced asthma, were included. We found them to be an important alternative source of treatment for asthma, since some have comparable efficacies with drugs commonly used in the modern system against asthma. All the reported medicinal plants confirmed their traditional use against asthma or its related inflammation. The present review provides faith in traditional information and also offers new insight into the potential of natural products against asthma.

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Anti‐asthmatic and anxiolytic effects of Herissantia tiubae, a Brazilian medicinal plant

Cited by 4 publications

References 39 publications

Brain Activation by H1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew)

Brain Activation by H1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew)

Dexamethasone Down-regulates Osteocalcin in Bone Cells through Leptin Pathway

Traditional Medicinal Plants Conferring Protection Against Ovalbumin-Induced Asthma in Experimental Animals: A Review

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