Anti-asthma effect of an antiviral drug, acyclovir: a clinical case and experimental study

OKADA, H.; OHNISHI, T.; HIRASHIMA, M.; FUJITA, J.; YAMAJI, Y.; TAKAHARA, J.; TODANI, T.

doi:10.1046/j.1365-2222.1997.1320808.x

Cited by 3 publications

(3 citation statements)

References 14 publications

(23 reference statements)

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“…Active oxygen species, toxic metabolites, and mediators released in the course of such reactions may precipate asthma. Further, ASA sensitivity is diminished in some AERD patients during acyclovir treatment of herpex simplex infection 33. IgG4 elevation might result from chronic antigenic stimulation of viral origin in AERD 34…”

Section: The Pathogenesis Of Aerdmentioning

confidence: 99%

Update on Recent Advances in the Management of Aspirin Exacerbated Respiratory Disease

2009

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Aspirin intolerant asthma (AIA) is frequently characterized as an aspirin (ASA)-exacerbated respiratory disease (AERD). It is a clinical syndrome associated with chronic severe inflammation in the upper and lower airways resulting in chronic rhinitis, sinusitis, recurrent polyposis, and asthma. AERD generally develops secondary to abnormalities in inflammatory mediators and arachidonic acid biosynthesis expression. Upper and lower airway eosinophil infiltration is a key feature of AERD; however, the exact mechanisms of such chronic eosinophilic inflammation are not fully understood. Cysteinyl leukotriene over-production may be a key factor in the induction of eosinophilic activation. Genetic studies have suggested a role for variability of genes in disease susceptibility and response to medication. Potential genetic biomarkers contributing to the AERD phenotype include HLA-DPB1*301, LTC4S, ALOX5, CYSLT, PGE2, TBXA2R, TBX21, MS4A2, IL10 -1082A > G, ACE -262A > T, and CRTH2 -466T > C; the four-locus SNP set was composed of B2ADR 46A > G, CCR3 -520T > G, CysLTR1 -634C > T, and FCER1B -109T > C. Management of AERD is an important issue. Aspirin ingestion may result in significant morbidity and mortality, and patients must be advised regarding aspirin risk. Leukotriene receptor antagonists (LTRA) that inhibit leukotriene pathways have an established role in long-term AERD management and rhinosinusitis. Aspirin desensitization may be required for the relief of upper and lower airway symptoms in AERD patients. Future research should focus on identification of biomarkers for a comprehensive diagnostic approach.

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Section: The Pathogenesis Of Aerdmentioning

confidence: 99%

Update on Recent Advances in the Management of Aspirin Exacerbated Respiratory Disease

2009

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“… 2 Pemirolast potassium works as an inhibitor of eosinophil chemotaxis 9 and has been used for treatment of bronchial asthma and allergic rhinitis. 10 In our case, it showed a marked effect and we did not need to use steroid therapy.…”

Section: Discussionmentioning

confidence: 46%

A case of eosinophilic cystitis in a 5‐year‐old boy

et al. 2000

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“…We found that three of the top 25 (vancomycin, metamizole sodium, and rifampicin) that mimicked signature 1 ( Fig. 2 ) worsened asthma symptoms in people ( 14 , 21 , 39 ) ( Table 1 ), whereas seven were beneficial and decreased airway obstruction ( 57 ), smooth muscle contraction ( 6 , 99 ), and AHR ( 3 , 22 ) ( Table 1 ). For signature 2 ( Fig.…”

Section: Resultsmentioning

confidence: 97%

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity

Reznikov

Meyerholz

Alaiwa

et al. 2018

American Journal of Physiology-Lung Cellular and Molecular Phys

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Mainstay therapeutics are ineffective in some people with asthma, suggesting a need for additional agents. In the current study, we used vagal ganglia transcriptome profiling and connectivity mapping to identify compounds beneficial for alleviating airway hyperreactivity (AHR). As a comparison, we also used previously published transcriptome data from sensitized mouse lungs and human asthmatic endobronchial biopsies. All transcriptomes revealed agents beneficial for mitigating AHR; however, only the vagal ganglia transcriptome identified agents used clinically to treat asthma (flunisolide, isoetarine). We also tested one compound identified by vagal ganglia transcriptome profiling that had not previously been linked to asthma and found that it had bronchodilator effects in both mouse and pig airways. These data suggest that transcriptome profiling of the vagal ganglia might be a novel strategy to identify potential asthma therapeutics.

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Anti-asthma effect of an antiviral drug, acyclovir: a clinical case and experimental study

Abstract: These results suggest that acyclovir exhibits not only antiviral but also antiasthma activity.

Cited by 3 publications

References 14 publications

Update on Recent Advances in the Management of Aspirin Exacerbated Respiratory Disease

Update on Recent Advances in the Management of Aspirin Exacerbated Respiratory Disease

A case of eosinophilic cystitis in a 5‐year‐old boy

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity

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