A case of eosinophilic cystitis in a 5‐year‐old boy

Sano, Koki; Terashima, Kazumitsu; Gotoh, Kazuko; Ijiri, Rieko; Tanaka, Yukichi

doi:10.1046/j.1442-2042.2000.00135.x

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…It has been suggested that if there is no amelioration with 4 weeks of treatment, other agents can be considered. Other agents tried in pediatric cases with a successful outcome were cyclosporin A [20], montelukast sodium, a leukotriene receptor antagonist [21], and pemirolast potassium, an inhibitor of eosinophil chemotaxis [22]. When a patient does not respond to the Fig.…”

Section: Discussionmentioning

confidence: 98%

Presenting manifestations of eosinophilic cystitis in two Filipino children

et al. 2009

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Eosinophilic cystitis is a very rare clinical disease entity in the pediatric population. We report two cases of Filipino children with eosinophilic cystitis who presented with irritative voiding symptoms, gross hematuria, peripheral eosinophilia, and hydroureteronephrosis and urinary bladder wall thickening visualized on ultrasonography and CT urography. Cystoscopy and transurethral biopsy confirmed the diagnosis. Both patients were started with corticosteroid with or without an antihistamine. Resolution from the signs and symptoms were observed in both patients as documented by disappearance of peripheral eosinophilia, normal urinalysis results, and resolution of the hydroureteronephrosis and urinary bladder wall thickening on ultrasonography on follow-up.

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Section: Discussionmentioning

confidence: 98%

Presenting manifestations of eosinophilic cystitis in two Filipino children

et al. 2009

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“…WBC white blood cells, E eosinophils, N neutrophils layers of the bladder wall [4]. EC seems to be related to dysregulation of the immune system, as suggested by reports of EC occurring in patients with a history of allergies [5][6][7][8] or subsequent to drug administration (penicillin, mitomycin, clometacin, cyclophosphamide, coumadin, tranilast, and thiotepa) [5,6]. The detection of transmural eosinophilic infiltration should also prompt suspicion of a differential diagnosis, including parasitosis, tumors, tuberculous cystitis, and bladder instrumentation [4,9].…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

How should eosinophilic cystitis be treated in patients with chronic granulomatous disease?

et al. 2014

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Background Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from the absence or malfunction of oxidative mechanism in phagocytic cells. The disease is due to a mutation in one of four genes that encode subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Affected patients experience severe infections and granuloma formation due to exuberant inflammatory responses. Some evidence suggests that eosinophilic cystitis (EC) is included in the spectrum of inflammatory manifestations. EC is an inflammatory disease, rare in childhood, which may require different, nonstandardized therapeutic approaches, ranging from antihistamines to cyclosporine.Case-Diagnosis/Treatment Herein we describe the cases of two CGD patients with CGD who experienced EC during hospitalization for a severe infection. Conclusions EC in immunocompetent children seems to have a self-limiting course, unlike in CGD patients, in whom it presents a prolonged and recurrent course. We focus on the effective therapy administered to our patients with CGD and review the corresponding literature.

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“…Dubucquoi et al [14] suggested that numerous activated eosinophils synthesized and secreted IL-5 that could enhance the activation of eosinophils and their cytotoxic potential in bladder tissues. Sano et al [15] suggested that the measurement of eosinophil cationic protein (ECP) in serum and urine was an appropriate marker.…”

Section: Resultsmentioning

confidence: 99%

Eosinophilic Cystitis

Kılıç

Erguvan²,

İpek³

et al. 2003

Urol Int

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Purpose: We present a large series of eosinophilic cystitis including 8 cases; 3 of them had tumor-like lesions. Materials and Methods: The archives of pathology clinic of Inonu University Medical Faculty were reviewed from 1988 to 2002. The characteristics of patients and their diseases were recorded. Data obtained from 180 cases (172 from the literature and 8 from the present series) was assessed. Results: Seven cases had symptoms such as dysuria, frequency, hematuria, suprapubic pain, and difficulty in voiding. One asymptomatic case with history of bladder carcinoma was diagnosed during routine cystoscopy. The findings were microhematuria in 6 cases, macrohematuria in 2, pyuria in 3, urinary infection in 1, eosinophilia in 1, hyperazotemia in 1, and bladder masses in 3. Cystoscopies detected edematous and erythematous areas in 5 cases and lesions mimicking bladder carcinoma in 3. One case did not take further treatment after cystoscopy and biopsy and completely recovered. Four cases underwent medical therapy with nonsteroidal anti-inflammatory drugs and antihistaminics. They became asymptomatic and control cystoscopies showed no abnormal finding. Two of three patients with mass lesions recovered after steroid therapy following transurethral resection. The lesion in the third recurred and he improved after a second course of steroid therapy. Conclusions: Eosinophilic cystitis is a rare pathology. Sometimes, it may simulate bladder malignancies. Biopsy is mandatory at diagnosis. Usually, it has a benign course and may be treated with fulguration, analgesics, antihistaminics and steroids, although recurrence is possible.

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A case of eosinophilic cystitis in a 5‐year‐old boy

Cited by 5 publications

References 10 publications

Presenting manifestations of eosinophilic cystitis in two Filipino children

Presenting manifestations of eosinophilic cystitis in two Filipino children

How should eosinophilic cystitis be treated in patients with chronic granulomatous disease?

Eosinophilic Cystitis

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