Anti-arthritic activity of standardised extract of Phyllanthus amarus in Freund's complete adjuvant induced arthritis

Mali, Sharad M.; Arulmozhi, S.; Kapase, Chinmay U; Bodhankar, Subhash L.; Mahadik, Kakasaheb R.

doi:10.1016/j.biomag.2011.09.004

Cited by 50 publications

(20 citation statements)

References 29 publications

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“…A number of preclinical and clinical studies have confirmed the medicinal properties of various Phyllanthus species that have been mentioned in traditional system of medicine (Calixto et al, ; Bagalkotkar et al, ; Joseph and Raj, ; Patel et al, ; Sarin et al, ). Previous studies have reported the analgesic, antiinflammatory, and anti‐arthritic activity of the standardized extracts of P. amarus (Mali et al, ; Kandhare et al, ; Chopade and Sayyad, , ). However, the effects of P. amarus plant on chronic inflammatory muscle hyperalgesia are unexplored, which has encouraged us to evaluate the effects of standardized extracts of P. amarus for their chronic pain modulating potential.…”

Section: Introductionmentioning

confidence: 99%

Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Chopade¹,

Sayyad²

2015

Phytotherapy Research

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The current study was aimed at evaluating the antihyperalgesic effects of lignans (phyllanthin and hypophyllanthin) and tannin (corilagin) rich three standardized extracts of Phyllanthus amarus in a model of chronic musculoskeletal inflammatory pain. Three percent carrageenan injected in the gastrocnemius muscle produced hyperalgesia to mechanical and heat stimuli ipsilaterally, which spreads to the contralateral side within 7 to 9 days. To investigate the effects on chronic thermal and mechanical hypersensitivity, three extracts of P. amarus in three doses (100, 200, and 400 mg/kg) were administered to animals intraperitoneally from 14th day to 22nd day after intramuscular injection of carrageenan. It was observed that intraperitoneal administrations of Phyllanthus extracts showed antihyperalgesic activity, as they elevated thermal and mechanical threshold, which was supported by histopathological observations along with reduction in prostaglandin E2 (PGE2) concentration. In conclusion, we strongly suggest that the observed antihyperalgesic and antiinflammatory effects of P. amarus in current pain model are mediated via spinal or supraspinal neuronal mechanisms, mainly by inhibition of PGE2. Modulation of chronic muscular inflammation may be due to presence of phytoconstituents like phyllanthin, hypophyllanthin, and corilagin, which offers a promising means for treatment of chronic muscle pain.

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Section: Introductionmentioning

confidence: 99%

Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Chopade¹,

Sayyad²

2015

Phytotherapy Research

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“…It also significantly increased the mechanical hyperalgesia and nociceptive threshold. The histopathology also revealed the control in inflammation with PA [24].…”

Section: Phyllanthus Amarusmentioning

confidence: 75%

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

Ashwlayan

Nimesh

2018

Journal of Bone Biology and Osteoporosis

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Rheumatoid arthritis (RA) is a chronic inflammatory and systemic auto immune disease, affecting people predominantly between the ages of 20-60 years with unpredictable course. About 1% of the world's population is afflicted by rheumatoid arthritis and is two to three times more common in women than men. This is a long lasting disease that can affect joints in any part of the body, most commonly the hands, wrists, and knees. Popularity of medicinal plants is increasing day by day due to side effects of allopathic medicines. Herbal medicinal plants have been used as major sources of cure of human diseases since time immemorial. Today, one fourth of world population depends on traditional medicine and 80% of the population relies on indigenous herbal medicinal plants. Even today most of the people lives in different developing countries depend on the plant derived medicines for the first line of primary health care because of least or no side effects.

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“…and Group G‐arthritic animals treated with AN 60 mg/kg co‐administered with 7.5 mg/kg NAB, p.o. Arthritis was induced to all the groups of animals except vehicle control group by a single injection of 0.1‐mL FCA in to sub plantar region of left hind paw on day 1 under light ether anesthesia (Mali et al ., ; Zhang et al , ). The dosing of the groups C, D, E, F and G started from day 12 and continued till day 28 once daily orally.…”

Section: Methodsmentioning

confidence: 98%

Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats

Balap

Lohidasan

Arulmozhi

et al. 2016

Phytotherapy Research

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The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) and Andrographolide (AN) with nabumetone (NAB) in wistar rats. Pharmacokinetic and pharmacodynamic interactions were studied after co-administration of APE and AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC and AUC of 6-MNA after co-administration with pure AN and APE has been observed. T of 6-MNA has been increased to 2 h from 1.5 h in AN + NAB treated group. Changes in mean residential time, clearance and volume of distribution of 6-MNA in APE + NAB treated group and AN + NAB treated group indicated interference of other components of APE other than AN. In pharmacodynamic study, significant decrease in antiarthritic activity of NAB on concomitant administration with APE and AN has been observed. The study concludes that NAB exhibits pharmacokinetic and pharmacodynamic interactions with APE and AN in rats thus alarms the concomitant use of herbal preparations containing APE and AN with NAB. Further study is needed to understand the mechanism and predict the herb-drug interaction in humans. Copyright © 2016 John Wiley & Sons, Ltd.

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Anti-arthritic activity of standardised extract of Phyllanthus amarus in Freund's complete adjuvant induced arthritis

Cited by 50 publications

References 29 publications

Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats

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