Anti-annexins autoantibodies: Their role as biomarkers of autoimmune diseases

Iaccarino, Leonardo; Ghirardello, Anna; Canova, Mariagrazia; Zen, Margherita; Bettio, Silvano; Nalotto, Linda; Punzi, Leonardo; Doria, Andrea

doi:10.1016/j.autrev.2011.04.007

Cited by 92 publications

(56 citation statements)

References 45 publications

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“…Annexin A2, which is expressed on a number of cell types, including monocytes and endothelial cells, has a high affinity for phospholipids [24] and is involved in the maintenance of cell membranes and the cytoskeleton [22]. Annexin A2 on endothelial cells acts as a receptor for both plasminogen and tissue plasminogen activator [25], thereby playing an important role in cell surface fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis

Pianta¹,

Drouin²,

Crowley³

et al. 2015

Clinical Immunology

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In this study, autoantibody responses to annexin A2 were found in 11–15% of 278 patients with Lyme disease, including in those with erythema migrans (EM), an early sign of the illness, and in those with antibiotic-responsive or antibiotic-refractory Lyme arthritis (LA), a late disease manifestation. In contrast, robust T cell reactivity to annexin A2 peptides was found only in patients with responsive or refractory LA. In LA patients, annexin A2 protein levels, which were higher in the refractory group, correlated with annexin A2 antibody levels in sera and synovial fluid. In addition, in patients with antibiotic-refractory LA who had anti-annexin A2 antibodies, synovial tissue had intense staining for annexin A2 protein, greater synovial fibroblast proliferation and more tissue fibrosis. Thus, a subset of LA patients had T and B cell responses to annexin A2, and in the refractory group, annexin A2 autoantibodies were associated with specific pathologic findings.

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Section: Discussionmentioning

confidence: 99%

Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis

Pianta¹,

Drouin²,

Crowley³

et al. 2015

Clinical Immunology

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show abstract

“…Autoantibodies might also block binding sites for opsonins or complement inhibitors. Autoantibodies directed against annexins have been described in SLE (18).…”

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confidence: 99%

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

Martin

Leffler

Blom

2012

Journal of Biological Chemistry

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“…Calcium and phospholipid interaction with the annexin C-terminal core contributes to the release of the N-terminal domain that, in turn, can interact with its protein ligand to exert its biological activity [4]. Auto-antibodies (Ab) against annexin 1, 2, 5 and 11 have been reported [5]. The present review will focus on annexin A2 (ANXA2, also known as annexin II, lipocortin II and p36) and anti-ANXA2 autoAb.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 97%