This study explores the relationship between time perspective (TP), cannabis use and risk perceptions associated with this substance. A sample of French students (n ¼ 198) were provided with a valid French version of the Zimbardo Time Perspective Inventory (ZTPI) scale. Risk perceptions linked to cannabis consumption were evaluated from a list of 22 items referring to different risks. Respondents were asked to declare how frequently they consumed this substance. Data analysis was based firstly on ZTPI scores, secondly on declared consumption and finally on the two risk perception indices which were established after factorial analysis. Results showed that TP acted as a significant predictor of both psychoactive substance use and of cannabis consumption frequency. Significant links between consumption and risk perceptions also appeared. A second series of analyses showed that TP moderated the link between cannabis consumption and risk perceptions. These findings highlight the importance of TP when analyzing the complexity of contemporary cannabis use.

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Among patients with venous thromboembolism (VTE), the persistent detection of antiphospholipid (aPL) antibodies (Ab) represents an independent high risk factor for recurrence. However, oral anticoagulation vitamin K antagonist therapy, frequently used in these patients, is problematic in assessing and/or confirming a diagnosis of primary aPL syndrome (pAPS), suggesting use of alternative strategies. For this reason, and by analogy with other autoimmune diseases, a flow cytometer approach testing peripheral T cell subsets (CD3, CD4, and CD8), B cell subsets (B1, transitional, naive, and memory), and NK cells can be proposed. As an example and to validate the concept, pAPS patients selected from the monocentric VTE case-control EDITH's cohort were selected during their follow-up. As suspected and in contrast to non-APS VTE patients, other autoimmune diseases, and controls, pAPS VTE patients displayed specific lymphocyte disturbances. Quantitative and qualitative modifications were related to total CD4 T cell reduction, a lower CD4/CD8 ratio, and disturbance in B cell homeostasis with increased proportions of B1 cells, transitional B cells (CD24CD38), and naive B cells (IgDCD27), while memory B cells (IgDCD27 and IgDCD27) were reduced. Interestingly, the absolute number of CD4 T cells positively correlated with IgG anti-cardiolipin Ab levels. Altogether, disturbances of T and B cell homeostasis characterized pAPS VTE patients during their follow-up. This suggests a means of profiling that could be used in addition to existing criteria to characterize them.