Anti-Allergic Effect of Para-Probiotics from Non-Viable Acetic Acid Bacteria in Ovalbumin-Sensitized Mice

Nakamura, Shin; Mitsunaga, Fusako

doi:10.4236/fns.2018.912099

Cited by 9 publications

(4 citation statements)

References 24 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Loss of microbial diversity represents the first step toward an altered microbial environment, promoting host susceptibility to diseases (Figure 2). Indeed, it is a common feature in the reported pathological conditions: neurodevelopmental disorders [122,123], inflammatory diseases [137,138], allergies [139][140][141], and metabolic syndrome [136]. Similarly, in all conditions, an increase in proinflammatory taxa (i.e., Proteobacteria) is reported, suggesting microbial participation in local and systemic low-grade inflammation [142][143][144].…”

Section: Microbiota Modulation For Therapeutic Purposesmentioning

confidence: 91%

“…Although more data are necessary before they can be fully understood and successfully used, there seem to be fairly strong indications that this approach may be beneficial [117]. As an example of how widespread the use of these products could be, beneficial effects of probiotics in human health have been reported, among others, in neurodevelopmental [122,123] and neurological diseases [124][125][126][127][128], diabetes [129][130][131], obesity [132][133][134][135], and metabolic syndrome [136], and in inflammatory diseases [137,138] and allergies [139][140][141].…”

Section: Microbiota Modulation For Therapeutic Purposesmentioning

confidence: 99%

See 1 more Smart Citation

Nutrition, Microbiota and Role of Gut-Brain Axis in Subjects with Phenylketonuria (PKU): A Review

Verduci

Carbone²,

Borghi

et al. 2020

Nutrients

View full text Add to dashboard Cite

The composition and functioning of the gut microbiota, the complex population of microorganisms residing in the intestine, is strongly affected by endogenous and exogenous factors, among which diet is key. Important perturbations of the microbiota have been observed to contribute to disease risk, as in the case of neurological disorders, inflammatory bowel disease, obesity, diabetes, cardiovascular disease, among others. Although mechanisms are not fully clarified, nutrients interacting with the microbiota are thought to affect host metabolism, immune response or disrupt the protective functions of the intestinal barrier. Similarly, key intermediaries, whose presence may be strongly influenced by dietary habits, sustain the communication along the gut-brain-axis, influencing brain functions in the same way as the brain influences gut activity. Due to the role of diet in the modulation of the microbiota, its composition is of high interest in inherited errors of metabolism (IEMs) and may reveal an appealing therapeutic target. In IEMs, for example in phenylketonuria (PKU), since part of the therapeutic intervention is based on chronic or life-long tailored dietetic regimens, important variations of the microbial diversity or relative abundance have been observed. A holistic approach, including a healthy composition of the microbiota, is recommended to modulate host metabolism and affected neurological functions.

show abstract

Section: Microbiota Modulation For Therapeutic Purposesmentioning

confidence: 91%

Section: Microbiota Modulation For Therapeutic Purposesmentioning

confidence: 99%

Nutrition, Microbiota and Role of Gut-Brain Axis in Subjects with Phenylketonuria (PKU): A Review

Verduci

Carbone²,

Borghi

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Some of the reported beneficial effects of probiotics in human health include anticancer [99][100][101][102][103][104][105][106][107][108][109][110][111], anti-allergic [112,113], anti-diabetic [114][115][116], anti-obesity [117][118][119][120], anti-pathogenic [121,122], immunomodulatory [123], and anti-inflammatory [124][125][126][127] activities [128], as reported in Table 1.…”

Section: Health Promoting Effect Of Prebiotics Probiotics and Synbimentioning

confidence: 99%

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Durazzo

Nazhand

Lucarini

et al. 2020

IJMS

View full text Add to dashboard Cite

Over the last few years, the application of nanotechnology to nutraceuticals has been rapidly growing due to its ability to enhance the bioavailability of the loaded active ingredients, resulting in improved therapeutic/nutraceutical outcomes. The focus of this work is nanoprebiotics and nanoprobiotics, terms which stand for the loading of a set of compounds (e.g., prebiotics, probiotics, and synbiotics) in nanoparticles that work as absorption enhancers in the gastrointestinal tract. In this manuscript, the main features of prebiotics and probiotics are highlighted, together with the discussion of emerging applications of nanotechnologies in their formulation. Current research strategies are also discussed, in particular the promising use of nanofibers for the delivery of probiotics. Synbiotic-based nanoparticles represent an innovative trend within this area of interest. As only few experimental studies on nanoprebiotics and nanoprobiotics are available in the scientific literature, research on this prominent field is needed, covering effectiveness, bioavailability, and safety aspects.

show abstract

“…are emerging [ 13 , 20 ]. There is also evidence about anti-inflammatory and anti-allergic activity exerted by acetic acid bacteria in foods (e.g., nata de coco, kombucha and fermented milk), but it is not clear whether the live or dead cells are responsible for these beneficial effects [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals

et al. 2021

View full text Add to dashboard Cite

Probiotics are live microorganisms that confer health benefits on the host. However, in recent years, several concerns on their use have been raised. In particular, industrial processing and storage of probiotic products are still technological challenges as these could severely impair cell viability. On the other hand, safety of live microorganisms should be taken into account, especially when administered to vulnerable people, such as the elderly and immunodeficient individuals. These drawbacks have enhanced the interest toward new products based on non-viable probiotics such as paraprobiotics and postbiotics. In particular, paraprobiotics, defined as “inactivated microbial cells (non-viable) that confer a health benefit to the consumer,” hold the ability to regulate the adaptive and innate immune systems, exhibit anti-inflammatory, antiproliferative and antioxidant properties and exert antagonistic effect against pathogens. Moreover, paraprobiotics can exhibit enhanced safety, assure technological and practical benefits and can also be used in products suitable for people with weak immunity and the elderly. These features offer an important opportunity to prompt the market with novel functional foods or nutraceuticals that are safer and more stable. This review provides an overview of central issues on paraprobiotics and highlights the urgent need for further studies aimed at assessing safety and efficacy of these products and their mechanisms of action in order to support decisions of regulatory authorities. Finally, a definition is proposed that unambiguously distinguishes paraprobiotics from postbiotics.

show abstract

Anti-Allergic Effect of Para-Probiotics from Non-Viable Acetic Acid Bacteria in Ovalbumin-Sensitized Mice

Cited by 9 publications

References 24 publications

Nutrition, Microbiota and Role of Gut-Brain Axis in Subjects with Phenylketonuria (PKU): A Review

Nutrition, Microbiota and Role of Gut-Brain Axis in Subjects with Phenylketonuria (PKU): A Review

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals

Contact Info

Product

Resources

About