Anti-allergic Effect of Intranasal Administration of Type-A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice

Abstract

The objective of the present work was to evaluate anti-allergic effects of intranasal administration of type-A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP-CZ) in ovalbumin (OVA)-induced experimental allergic rhinitis (AR) in BALB/c mice. Sixty male BALB/c mice were divided into six groups of ten each (G1-G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2-G6) were sensitized with OVA (500 μL solution, intraperitoneal) on alternate days for 13 days and had twice daily intranasal treatment from day 14-21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5 mg/mL, 20 μL/nostril) and G4-G6 received TAPP-CZ (3, 10 and 30 µg/kg in nostril), respectively. On day 21, mice were challenged with OVA (5 μL/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP-CZ (10 and 30 µg/kg in nostril) showed significant attenuation in OVA-induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP-CZ showed anti-allergic efficacy in animal model of AR.

Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

“…63,64 It is considered that GSH act as cofactor for several protective enzymes that are important in defense mechanism of body from oxidative stress. 33,[65][66][67] There is association between the increase in blood pressure and the oxidative stress. Several clinical investigations showed that serum concentrations of MDA are high in the hypertensive patients than in normal individuals.…”

Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats

“…It has been reported that activated phagocytic leukocytes have an ability to produce superoxide radicals that eventually leads to the production of reactive hydroxyl radical and peroxide (Adil et al, 2014[1]; Aswar et al, 2015[3]). Administration of TNBS may disrupt the endogenous antioxidant defense system leading to colonic oxidative damage (Li et al, 2011[47]).…”

Antiulcer Potential of Morin in Acetic acid-Induced Gastric Ulcer via Modulation of Endogenous Biomarkers in Laboratory Animals

“…Reactive Oxygen Species (ROS) played a vital role in the progression of various diseases [29][30][31][32][33][34] . However, natural compounds along with potential antioxidant property are topics of high current interest for the treatment of such disease of ROS originated and gastric ulcer being one of them.…”