Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats

Sadar, Smeeta S.; Vyawahare, N. S.; Bodhankar, Subhash L.

doi:10.17179/excli2016-393

Cited by 32 publications

(10 citation statements)

References 59 publications

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“…Moreover, the intestinal microbial changes in TNBS-induced mice showed a decrease in α-diversity, possibly beneficial bacteria decreased and harmful bacteria increased, similar to those in patients with Crohn's disease ( 100 ). Interestingly, some experts believe that it causes intestinal ulcer in animals to be similar to UC ( 101 ). Hence, it is still doubtful whether the TNBS-induced colitis model can represent human UC.…”

Section: Common Animal Models Of Ucmentioning

confidence: 99%

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

et al. 2021

Front. Med.

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Ulcerative Colitis (UC) is a chronic inflammatory bowel disease. The prolonged course of UC and the lack of effective treatment management make it difficult to cure, affecting the health and life safety of patients. Although UC has received more attention, the etiology and pathogenesis of UC are still unclear. Therefore, it is urgent to establish an updated and comprehensive understanding of UC and explore effective treatment strategies. Notably, sufficient evidence shows that the intestinal microbiota plays an important role in the pathogenesis of UC, and the treating method aimed at improving the balance of the intestinal microbiota exhibits a therapeutic potential for UC. This article reviews the relationship between the genetic, immunological and microbial risk factors with UC. At the same time, the UC animal models related to intestinal microbiota dysbiosis induced by chemical drugs were evaluated. Finally, the potential value of the therapeutic strategies for restoring intestinal microbial homeostasis and treating UC were also investigated. Comprehensively, this study may help to carry out preclinical research, treatment theory and methods, and health management strategy of UC, and provide some theoretical basis for TCM in the treatment of UC.

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Section: Common Animal Models Of Ucmentioning

confidence: 99%

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

et al. 2021

Front. Med.

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“…The treatment of ferulic acid reduced MPO activity from 18.78 to 9.78 U/mg in 2,4,6trinitrobenzenesulfonic acid-induced colitic Sprague Dawley rats. It also reduced oxidative stress and modulated inflammatory cytokines and iNOS (Sadar et al, 2016).…”

Section: Discussionmentioning

confidence: 91%

Protective effect of feruloylated oligosaccharides on dextran sulfate sodium‐induced ulcerative colitis in rats

Gong

Wang

et al. 2022

Food Frontiers

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Feruloylated oligosaccharides (FOs), comprising ferulic acid and arabinoxylans, have already been proved to possess beneficial properties that are closely related to the pathogenesis of ulcerative colitis (UC). This study aims at investigating the protective effect of FOs on chronic UC rats and its regulatory mechanisms. The study demonstrated that FOs alleviated the chronic UC through a combination of pharmacological mechanisms, including antioxidant, inhibiting the inflammatory response, improving the gut barrier and modulating the overall structure of gut microbiota. FOs showed immunomodulatory effect by downregulating the relative expression of proinflammatory cytokines IL‐1β, IL‐6, and TNF‐α in colon tissue. In addition, the FOs exhibited antioxidant activity by increasing SOD activity but reducing MDA content, iNOS activity and NO content. In terms of intestinal barrier, FOs inhibited gut barrier damages by enhancing tight junction protein expression (claudin‐3, occluding, and ZO‐1) and recovering the ultrastructure of intestinal barrier. Moreover, FOs also could partially restore the intestinal biodiversity in the DSS‐induced UC rats and increased the species richness of beneficial bacteria such as Akkermansia and Roseburia. These findings provide novel insights into the FOs‐mediated alleviation of chronic UC and will facilitate the preventive strategies for chronic UC.

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“…Within three to seven days after rectal treatment of TNBS, rats develop acute inflammatory and substantial disruption to an intestinal barricade [ 22 ]. Ethanol breaks down the mucosa barrier, and TNBS haptenizes autologous colonies as well as bacterial receptors via the human immune system.…”

Section: Resultsmentioning

confidence: 99%

Detection of the Content of Two Coumarins, IM and ISOIM, and Their Mechanism of Action on Colitis Rats in Angelica albicans

Zhang

Dong

Pan

2022

Computational and Mathematical Methods in Medicine

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Angelica albicans is being used in the cure of different, respiratory, neuromuscular, and cutaneous diseases in traditional eastern medicine. The pharmacokinetic (PK) characteristics of imperatorin (IM) and isoimperatorin (ISOIM), the main effective components in Angelica albicans, were investigated. The rapid, subtle, and measuring the PKs of a drug, a validated UPLC/MS/MS methodology was designed for a total of 2 furanocoumarins in 2,4,6-trinitrobenzene sulfonic acid-stimulated and untreated mice. After that, blood samples were obtained. Angelica albicans (0.5 and 1.0 g/kg) was given orally, taken regularly from the tail vein. The time it takes for colitis rats to achieve their maximal concentration ( T max ) imperatorin and isoimperatorin was considerably postponed. In comparison to normal rats, all furanocoumarins had lesser peak plasma concentrations ( C max ) and higher represent residence durations. The area below the C max time-curve or clearance half-life did not differ significantly. In normal rats, all two furanocoumarins attained maximal plasma levels between 40 and 75 minutes, demonstrating fast oral absorption. The periods to attain T max of the two furanocoumarins, on the other hand, were shorter than in earlier studies. Therefore, colitis-linked alterations in the drug-absorption stage may result in a late T max and lowered C max , which have no effect on its clearance in half-life. Hence, conclusively, as a result, more consideration should be given to the prescription and administration of Angelica albicans in colitis individuals, and more research is needed to determine whether the changed PK profile was clinically meaningful for medicinal dose.

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Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats

Cited by 32 publications

References 59 publications

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

Protective effect of feruloylated oligosaccharides on dextran sulfate sodium‐induced ulcerative colitis in rats

Detection of the Content of Two Coumarins, IM and ISOIM, and Their Mechanism of Action on Colitis Rats in Angelica albicans

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