Anti-Adipogenic and Anti-Oxidant Activities of Mugwort and Pine Needles Fermented Using<i>Leuconostoc mesenteroides</i>1076

Lee, Young-Jun; Yu, Seok-Yeong; Lee, Jong Seok; Kim, Myoung-Dong; Lee, Dae-Won; Kim, Kui-Jin; Lee, Ok‐Hwan

doi:10.1080/08905436.2014.895945

Cited by 5 publications

(2 citation statements)

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“…Therefore, there is an increasing demand for the use of alternative modalities to control ROS in adipocytes. The beneficial activity of fermentation by gut bacteria has been extensively studied 17 , 18 . However, the effect of this process on scavenging lipid accumulation-induced ROS in adipocyte is still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…This fermentative Gram-positive bacterium belongs to the Firmicutes phylum and is a commensurate organism in the mammalian gut microbiome that is frequently associated with fermenting traditional functional foods 21 , 22 . Many L. mesenteroides -fermented products show antioxidant activity reducing the accumulation of ROS 18 , 22 – 24 . Despite the lack of reports of its electrogenic potential, L. mesenteroides possessed ferric iron reductase activity 23 .…”

Section: Introductionmentioning

confidence: 99%

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Leuconostoc mesenteroides mediates an electrogenic pathway to attenuate the accumulation of abdominal fat mass induced by high fat diet

Pham

Yang

Balasubramaniam

et al. 2020

Sci Rep

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Although several electrogenic bacteria have been identified, the physiological effect of electricity generated by bacteria on host health remains elusive. We found that probiotic Leuconostoc mesenteroides (L. mesenteroides) can metabolize linoleic acid to yield electricity via an intracellular cyclophilin A-dependent pathway. Inhibition of cyclophilin A significantly abolished bacterial electricity and lowered the adhesion of L. mesenteroides to the human gut epithelial cell line. Butyrate from L. mesenteroides in the presence of linoleic acid were detectable and mediated free fatty acid receptor 2 (Ffar2) to reduce the lipid contents in differentiating 3T3-L1 adipocytes. Oral administration of L. mesenteroides plus linoleic acid remarkably reduced high-fat-diet (HFD)-induced formation of 4-hydroxy-2-nonenal (4-HNE), a reactive oxygen species (ROS) biomarker, and decreased abdominal fat mass in mice. The reduction of 4-HNE and abdominal fat mass was reversed when cyclophilin A inhibitor-pretreated bacteria were administered to mice. Our studies present a novel mechanism of reducing abdominal fat mass by electrogenic L. mesenteroides which may yield electrons to enhance colonization and sustain high amounts of butyrate to limit ROS during adipocyte differentiation.

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Section: Introductionmentioning

confidence: 99%