Anti-adhesive functions of CD43 expressed on colon carcinoma cells through the modulation of integrins

Park, Weon Seo; Kim, Hae Jung; Lee, Geon Kook; Son, Hyeon S.; Bae, Young-Soo

doi:10.1016/j.yexmp.2011.10.009

Cited by 9 publications

(9 citation statements)

References 46 publications

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“…In western countries, the synchronization incidence of both tumor types is as high as 35.8%. [23] However, previous studies have shown some differences in FA composition between GC and CRC patients, and this could be attributed to the comparison of different sample types including racial differences and varying detection methods. However, in this study, we have undertaken for the first time, the direct comparison of FAs composition in erythrocyte and platelet membranes of GC and CRC patients using GC-MS in Chinese Han population.…”

Section: Resultsmentioning

confidence: 99%

Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor

Lin

Li²,

Liu³

et al. 2017

Medicine

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Section: Resultsmentioning

confidence: 99%

Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor

Lin

Li²,

Liu³

et al. 2017

Medicine

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“…Specific integrin heterodimers are expressed in different cancer cells, and the growth and migration of the cells depend on the interactions between the integrins and their extracellular ligands. Integrins link the extracellular matrix to intracellular signaling molecules and regulate a number of cellular processes, including adhesion, signaling, motility, survival, gene expression, growth, and differentiation [Deb et al, ; Park et al, ]. Endometrial cancer cells express high levels of αvβ3 compared to normal endometrium [Castelbaum et al, ] and αvβ3 has been shown to be involved in tumor metastasis.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Transforming Growth Factor‐β (TGF‐β) Signaling by Scutellaria baicalensis and Fritillaria cirrhosa Extracts in Endometrial Cancer

Bokhari

Syed

2015

J of Cellular Biochemistry

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Transforming growth factor-β (TGF-β), regulates cell proliferation, angiogenesis, metastasis, and is an inducer of epithelial-mesenchymal transition (EMT). Cancer cells exhibit activated TGF-β/SMAD signaling pathway and its inhibition is an attractive strategy for cancer treatment. The Chinese Herbs Scutellaria baicalensis (SB) and Fritillaria cirrhosa (FC) have been shown to be beneficial to cancer patients, but the mechanisms by which the extracts of two herbs elicit the beneficial effects are unclear. In this study, we have used human endometrial cancer cells to assess the anticancer efficacy of SB and FC on TGF-β signaling pathway components. SB and FC treatment of cancer cells resulted in a significant decrease in expression of TGF-β isoforms, TGF-β receptors, and SMADs. Both herbs effectively inhibited basal and TGF-β1-induced cancer cell proliferation and invasion, which was accompanied with abrogation of Snail, Slug, matrix metalloproteinases (MMPs), αvβ3 integrin, focal adhesion kinase (FAK), and p-FAK expression. An inhibitor of TGF-βRI blocked TGF-β1-induced cell invasion and significantly diminished antitumor effects of SB and FC. These results suggest that SB and FC block endometrial cancer growth by downregulating TGF-β/SMAD signaling pathway.

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“…Although CD43 is associated in the development of several types of cancer (23)(24)(25), it is also involved in the immune response to several pathogens, such as Trypanosoma cruzi, HIV, and MTB (26)(27)(28). CD43 may bind specifically to Mycobacteria but not to other types of bacteria (18,19,29).…”

Section: Clinical Relevancementioning

confidence: 99%

Common Polymorphisms in the CD43 Gene Region Are Associated with Tuberculosis Disease and Mortality

Campo

Randhawa

Dunstan

et al. 2015

Am J Respir Cell Mol Biol

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CD43, a surface glycoprotein, regulates Mycobacterium tuberculosis macrophage binding, replication, and proinflammatory cytokine induction in a murine model. We hypothesized that single-nucleotide polymorphisms (SNPs) in the CD43 gene region are associated with human tuberculosis (TB) susceptibility. We performed a casepopulation study in discovery (352 TB cases and 382 control subjects) and validation cohorts (339 TB cases and 376 control subjects). We examined whether 11 haplotype-tagging SNPs in the CD43 gene region were associated with tuberculous meningitis (TBM) and pulmonary TB (PTB) in Vietnam. Three SNPs from the CD43 gene region were associated with TB susceptibility with a genotypic model. The association fit a recessive genetic model and was greater for TBM than for PTB (for TBM: rs4788172, odds ratio [OR], 1.64; 95% confidence interval [CI], 1.04-2.59, rs17842268 [OR, 2.20; 95% CI, 1.29-3.76, and rs12596308 [OR, 2.38; 95% CI, 1.47-3.89]). Among TBM cases, rs17842268 was associated with decreased survival (hazard ratio, 2.7; 95% CI, 1.1-6.5; P = 0.011). In addition, rs12596308 and rs17842268 were associated with focal neurologic deficit at TBM presentation. Our data suggest that CD43 polymorphisms are associated with TB susceptibility, disease manifestations, and worse outcomes. To our knowledge, this is the first report that links CD43 genetic variants with susceptibility and outcome from a disease.

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Anti-adhesive functions of CD43 expressed on colon carcinoma cells through the modulation of integrins

Cited by 9 publications

References 46 publications

Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor

Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor

Inhibition of Transforming Growth Factor‐β (TGF‐β) Signaling by Scutellaria baicalensis and Fritillaria cirrhosa Extracts in Endometrial Cancer

Common Polymorphisms in the CD43 Gene Region Are Associated with Tuberculosis Disease and Mortality

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