“…In the present article, we showed that C. (Li, Zhang, Zeng, Yang, & Deng, 2011;Regueiro et al, 2014;Troise, Ferracane, Palermo, & Fogliano, 2014 and reducing the desquamation impairment, respectively (Yin, Hwang, & Lee, 2019;Zhang et al, 2016;Zouboulis, Dessinioti, Tsatsou, & Gollnick, 2017). Indeed, hyper-keratinization of the infundibulum contributes to pore enlargement, together with alterations in the thickness of the epidermis and a loss of dermis structural components, thus the role of kallikrein 5 in reducing skin desquamation represents a key issue when treating this type of dysfunctions (Murakami, Kawamura, Jie, & Tanno, 2006).…”