Anti-Acne Effects of Oriental Herb Extracts: A Novel Screening Method to Select Anti-Acne Agents

Nam, Chunja; Kim, S; Sim, Ye Chan; Chang, Ikwhang

doi:10.1159/000069030

Cited by 55 publications

(33 citation statements)

References 11 publications

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“…Therefore, there has been growing demand from both the cosmetic and pharmaceutical industries for the screening of natural products to discover effective anti-acne ingredients which are well tolerated by the skin. However, there has been scant evidence that anti-acne natural ingredients can yield clinical benefits from controlled trials and histopathological analysis, while most studies just focused on in vitro efficacy [6,7]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Kwon¹,

Yoon²,

Park³

et al. 2014

Dermatology

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Background: Screening of natural compounds for the development of anti-acne therapeutic agents has been steadily required considering various side effects of acne medications. However, previous studies have mainly focused on experimental tests without clinical trials and histopathological analysis. Objectives: To compare the clinical efficacy, safety and histopathological changes between Lactobacillus-fermented Chamaecyparis obtusa (LFCO) and existing tea tree oil (TTO). Methods: A total of 34 patients were instructed to apply 5% LFCO to the involved areas of a randomly allocated side and 5% TTO extract to the other side for 8 weeks in a double-blind split-face clinical trial. Results: After 8 weeks, inflammatory acne lesions were reduced by 65.3% on the LFCO side and by 38.2% on the TTO side. LFCO was also superior to TTO in the onset time of efficacy (p < 0.05). The LFCO side further demonstrated improvement for non-inflammatory lesions (52.6%, p < 0.05), decreased size of sebaceous glands and sebum output reductions. Patients' subjective satisfaction was also higher without severe adverse reactions. Protein expressions of nuclear factor κB decreased earlier on the LFCO side, and those of interleukin-1a (IL-1a), IL-8, insulin-like growth factor 1 receptor and sterol regulatory element-binding protein 1 decreased subsequently. Ultra-performance liquid chromatography/high-resolution mass spectrometry further demonstrated that the contents of dihydroxybenzoic acid, taxifolin and quercetin were increased in LFCO after fermentation. Conclusions: LFCO treatment was rapid and effective for treating acne lesions compared to TTO. Histopathological findings correlated well with the clinical acne grade and treatment response. This novel natural compound appears to be effective and safe for acne treatment.

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Section: Introductionmentioning

confidence: 99%

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Kwon¹,

Yoon²,

Park³

et al. 2014

Dermatology

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“…tetracycline (Gollnick et al, 2003;Han et al, 2010;Ravenscroft, 2005). , P. acnes , , 2 (Eom et al, 2016;Kim et al, 2016;Nam et al, 2003;Tan, 2003). , (Eom et al, 2016;Lee et al, 2014a , (Kim et al, 2009;Lee et al, 2014b;Poquet et al, 2008).…”

mentioning

confidence: 99%

Anti-inflammatory Effects of Chitosan-phytochemical Conjugates against Propionibacterium acnes-induced Inflammation

Kim¹,

Je²,

Kim³

2016

Korean Journal of Fisheries and Aquatic Sciences

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Propionibacterium acnes infection in skin tissue often causes acne vulgaris, commonly characterized by inflammatory papules, pustules, and nodules. Chitosan and its derivatives possess strong anti-inflammatory effects. In this study, the anti-inflammatory activity of chitosan-phytochemical conjugates on P. acnes-infected human skin keratinocytes (HaCaT) was evaluated. We designed a model of P. acnes-induced inflammation in viable HaCaT cells. Nitric oxide (NO), an inflammatory marker, was successfully elevated by P. acnes infection in HaCaT cells in a dose-dependent manner. Furthermore, the levels of NO were reduced by treatment with chitosan-phytochemical conjugates (chitosancaffeic acid, -ferulic acid and -sinapic acid) in a dose-dependent manner. Among these conjugates, chitosan-caffeic acid exhibited the strongest NO suppression in HaCaT cells infected with P. acnes. The results obtained in this study suggest that chitosan-phytochemical conjugates could be used as a potential therapeutic agent against acne vulgaris.

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“…The ethanol extract (0.01%) of A. dahurica also shown to suppress neutrophil chemotaxis comparable to the effect of erythromycin (Nam et al 2003).…”

Section: Antimicrobial Herbs For Acnementioning

confidence: 87%

Different approaches of alternative medicines in acne vulgaris treatment

Ghosh

Nagore

Kadbhane

et al. 2011

Orient Pharm Exp Med

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Acne vulgaris is common dermatological disorder primarily acts on children and adolescents. This affects approximately 80% of the population between the ages of 12-25 years. The clinically used anti-acne drugs suffer from the disadvantage of side effects and high cost of treatment. Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for the treatment of skin disorder like acne vulgaris. The use of traditional medicines and phytopharmaceuticals for treating various skin ailments dates back several centuries. The aim of the present review is to compile relevant data on the mechanisms of action of various natural compounds from ethnomedicinal plants and their role in the resolution of acne vulgaris. An attempt is also being made to enumerate the possible leads from Indian traditional medicinal system for the treatment of acne. We tried to provide the readers with the array of outcome variables, which can be further worked upon in clinical studies. Finally, this paper puts forth issues that need to be addressed by researchers in the future.

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Anti-Acne Effects of Oriental Herb Extracts: A Novel Screening Method to Select Anti-Acne Agents

Cited by 55 publications

References 11 publications

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Anti-inflammatory Effects of Chitosan-phytochemical Conjugates against Propionibacterium acnes-induced Inflammation

Different approaches of alternative medicines in acne vulgaris treatment

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