Anthropomorphic optical phantom of the neonatal thorax: a key tool for pulmonary studies in preterm infants

Pacheco, Andrea; Li, Haiyang; Chakravarty, Monisha; Sekar, Sanathana Konugolu Venkata; Andersson‐Engels, Stefan

doi:10.1117/1.jbo.25.11.115001

Cited by 17 publications

(15 citation statements)

References 29 publications

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“…The phantoms previously created to investigate the clinical application of GASMAS in neonatal respiratory healthcare had a hollow cavity with the outer geometry of the lung without the inner structure mimicking the alveolar anatomy. 21 , 22 The phantom designed in this study recreated inflated alveoli surrounded by lung tissue.…”

Section: Methodsmentioning

confidence: 99%

Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes

et al. 2021

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Section: Methodsmentioning

confidence: 99%

Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes

et al. 2021

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“…Other experiments, such as gas sensing, monitoring and evaluation of gas spectroscopy, are also unique to the lung model compared with other organ models. Tobo et al [144] showed a multi structure tissue model of the thorax of a neonate by indirect 3D printing method, which can be used for gas in scattering media absorption spectroscopy (GASMAS) measurements of oxygen content within the lung cavity (Figure 9E). In particular, they developed a specific mixture constituting of ink and spheres to match the optical properties of the different organs.…”

Section: Thorax and Tracheamentioning

confidence: 99%

Section: Applications Of 3d Printed Organ Modelsmentioning

confidence: 99%

3D Printing of Physical Organ Models: Recent Developments and Challenges

Jin

Kang

et al. 2021

Advanced Science

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Physical organ models are the objects that replicate the patient-specific anatomy and have played important roles in modern medical diagnosis and disease treatment. 3D printing, as a powerful multi-function manufacturing technology, breaks the limitations of traditional methods and provides a great potential for manufacturing organ models. However, the clinical application of organ model is still in small scale, facing the challenges including high cost, poor mimicking performance and insufficient accuracy. In this review, the mainstream 3D printing technologies are introduced, and the existing manufacturing methods are divided into "directly printing" and "indirectly printing", with an emphasis on choosing suitable techniques and materials. This review also summarizes the ideas to address these challenges and focuses on three points: 1) what are the characteristics and requirements of organ models in different application scenarios, 2) how to choose the suitable 3D printing methods and materials according to different application categories, and 3) how to reduce the cost of organ models and make the process simple and convenient. Moreover, the state-of-the-art in organ models are summarized and the contribution of 3D printed organ models to various surgical procedures is highlighted. Finally, current limitations, evaluation criteria and future perspectives for this emerging area are discussed.

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“…They include diffuse reflectance spectroscopy [7,8], endogenous [9] or exogenous fluorescence spectroscopy [10,11], optical coherent tomography [12], and Raman spectroscopy [13]. Much effort is also being devoted to model the photon propagation through the lung by means of simulations [14,15] anthropomorphic lung phantoms [16,17], and ex vivo bovine lung tissues [18]. Conversely, there are not many attempts to probe the lung optically non-invasively transcutaneously.…”

Section: Introductionmentioning

confidence: 99%

Initial non-invasive in vivo sensing of the lung using time domain diffuse optics

Pifferi¹,

Miniati²,

Farina³

et al. 2022

Preprint

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Non-invasive in vivo sensing of the lung with light would help diagnose and monitor pulmonary disorders (caused by e.g. COVID-19, emphysema, immature lung tissue in infants). We investigated the possibility to probe the lung with time domain diffuse optics, taking advantage of the increased depth (few cm) reached by photons detected after a long (few ns) propagation time. An initial study on 5 healthy volunteers included time-resolved broadband diffuse optical spectroscopy measurements at 3 cm source-detector distance over the 600-1100 nm range, and long-distance (6-9 cm) measurements at 820 nm performed during a breathing protocol. The interpretation of the in vivo data with a simplified homogeneous model yielded a maximum probing depth of 2.6-3.9 cm, suitable to reach the lung. Also, signal changes related to the inspiration act were observed, especially at high photon propagation times. Yet, intra-and inter-subject variability and inconsistencies, possibly alluring to competing scattering and absorption effects, prevented a simple interpretation. Aspects to be further investigated to gain a deeper insight are discussed.

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Anthropomorphic optical phantom of the neonatal thorax: a key tool for pulmonary studies in preterm infants

Cited by 17 publications

References 29 publications

Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes

Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes

3D Printing of Physical Organ Models: Recent Developments and Challenges

Initial non-invasive in vivo sensing of the lung using time domain diffuse optics

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