Anthropometrics, Metabolic Syndrome, and Mortality Hazard

Abstract

Independent indices (height, body mass index, a body shape index, and hip index) derived from basic anthropometrics have been found to be powerful predictors of mortality hazard, especially when the attributable risks are summed over these indices to give an anthropometric risk index (ARI). The metabolic syndrome (MS) is defined based on the co-occurrence of anthropometric, clinical, and laboratory criteria and is also widely employed for evaluating disease risk. Here, we investigate correlations between ARI and MS in a general population sample, the United States Third National Health and Nutrition Examination Survey. Baseline values of ARI and MS were also evaluated for their association with mortality over approximately 20 years of follow-up. ARI was found to be positively correlated with each component of MS, suggesting connections between the two entities as measures of cardiometabolic risk. ARI and MS were both significant predictors of mortality hazard. Although the association of ARI with mortality hazard was stronger than that of MS, a combined model with both ARI and MS score as predictors improved predictive ability over either construct in isolation. We conclude that the combination of anthropometrics and clinical and laboratory measurements holds the potential to increase the effectiveness of risk assessment compared to using either anthropometrics or the current components of MS alone.

Association of Body Shape Index (ABSI) with Hand Grip Strength

“…After Z score transformation, the magnitude of the correlations of grip strength with ABSI and BMI was about 0.2, meaning that most variability in grip strength could not be accounted for by these simple anthropometrics. This correlation magnitude is similar to that previously found between ABSI and MS score [53], and manifests in the extensive scatter depicted in Figure 1. We tentatively interpret this relatively low correlation as indicating that grip strength on the one hand and ABSI and BMI on the other measure different, though overlapping, aspects of health, and may have differing metabolic and genetic correlates.…”

“…Mortality hazard for ABSI and BMI have also been previously described and connected with abdominal obesity as conceptualized by metabolic syndrome (MS). In fact, including ABSI in place of WC or BMI optimized mortality prediction with MS scoring [53].…”

Prospects for Using the Natural Antioxidant Compounds in the Obesity Treatment

“…Thereby, it was determined that in animals administered with the test concentrate, the content of FFA and TAG decreased, respectively, by 29 with more favorable lipoprotein fractions ratio in this group of animals treated by APFC. Thus, the content of the atherogenic fraction apoB-LP decreased (by 23.9%), while the level of antiatherogenic HDL was increased (content did not significantly differ from the same index in healthy animals), which indicates a reduction in the risk of proatherogenic changes and atherosclerosis development ( Table 2).…”

“…In general, observed changes indicate the ability of the studied concentrate to prevent the induction of proatherogenic disorders and the MS negative influence, such as the atherosclerosis development. These harmful factors are the main cause of the cardiovascular diseases development and their complications in patients with metabolic disorders [29].…”

Association of Metabolic Syndrome and Its Components with Survival of Older Adults

“…Hess et al in their research reported that MetS was independently associated with a 70% elevation in the risk for sudden cardiac death (19). In another study, Krakauer et al showed that hyperglycemia, hypertension, and low HDL made the greatest association of MetS with mortality hazard ratio (23). A cohort study with 20 years follow-up showed that patients with MetS and impaired blood glucose had the highest mortality rate in comparison with those who did not have MetS or hyperglycemia (24).…”