Anthropometric Indicators of Adiposity Related to Body Weight and Body Shape as Cardiometabolic Risk Predictors in British Young Adults: Superiority of Waist-to-Height Ratio

Amirabdollahian, Farzad; Haghighatdoost, Fahimeh

doi:10.1155/2018/8370304

Cited by 48 publications

(50 citation statements)

References 160 publications

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“…BMI is the most widely used measure to diagnose overweight and obesity, whereas WC and WHtR better indicator of intraabdominal fat, have been suggested to be more accurate to predict CM than BMI. 24,25,27,[38][39][40] Results of the current study demonstrated a significant correlation between most of the anthropometric indicators of adiposity and CM risk parameters. The strongest associations were observed with WHtR and WC.…”

Section: Discussionsupporting

confidence: 50%

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

Kerkadi¹,

Suleman²,

Salah³

et al. 2020

DMSO

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Background: In Qatar more than 70% 0f the adults are overweight and obese. Different adiposity assessment methods have been proposed to identify individuals at cardio-metabolic risk. Purpose: This study aimed to compare anthropometric indicators with Dual-energy X-ray absorptiometry (DXA)-derived adiposity indicators in predicting cardio-metabolic risk among Qatari adults. Patients and Methods: A random sample of five hundred and fifty-eight (558) healthy Qatari adults (men and women) aged 20 to 50 years was obtained from Qatar Biobank survey data. Anthropometric data (weight, height, and waist circumference), the DXAderived data, and cardio-metabolic (CM) risk parameters were analyzed. A Spearman partial correlation coefficient, Receiver Operating Characteristics (ROC) curve and an area under curve (AUC) were used to assess the predicting ability of adiposity indicators for CM risk factors. Results: Adiposity indices (anthropometric and DXA) were significantly correlated with most of the CM indicators (r= −0.292 to 0.486, p< 0.001). The AUC of waist to height ratio (WHtR) was significantly higher than that of body mass index (BMI) and waist circumference (WC) in the prediction of low high density lipoprotein (HDL) (AUC=0.65, AUC=0.59; AUC=0.64), high low density lipoprotein (LDL) (AUC=0.67; AUC=0.62; AUC=0.66), high cholesterol (AUC=0.66; AUC=0.63; AUC=0.63), and high Homeostatic Model Assessment-(HOMA) (AUC= 0.81; AUC= 0.78; AUC=0.78). Among DXA-parameters, trunk fat had the highest AUCs for total cholesterol (AUC= 0.64, CI=0.56, 0.73), triglycerides and glucose index (TyG) (AUC=0.69, CI=0.64, 0.74), and HOMA (AUC=0.78, CI= 0.73, 0.84). Conclusion: Results of the present study show that adiposity indicators (WC and WHtR) are clinically valuable tools to identify individuals at risk of CVD compared to DXA-derived parameters, while DXA can provide more accurate estimates.

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Section: Discussionsupporting

confidence: 50%

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

Kerkadi¹,

Suleman²,

Salah³

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…Waist circumference (WC) reflects central obesity, and has been suggested to be superior to body mass index (BMI), particularly among Asian populations, in predicting cardiovascular disease risk 17 . Thus, WC may be a better indicator to reflect the effect of early-life famine exposure on adult risks of non-communicable chronic disease.…”

Section: Introductionmentioning

confidence: 99%

DNA methylation of the INSR gene as a mediator of the association between prenatal exposure to famine and adulthood waist circumference

Wang

Song

et al. 2020

Sci Rep

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The aims of this study were to explore whether DNA methylation at INSR and IGF2 mediated the association of prenatal exposure to the Chinese great famine with adulthood waist circumference (WC) and BMI. A total of 235 subjects were selected into the present study from severely affected province and a neighbor province with less severely affected famine in China through multi-stage clustered random sampling. DNA methylation at the INSR and IGF2 gene promoter regions was detected by the Sequenom’s MassARRAY system. The “mediation” package of R was used to evaluate the mediation effect of DNA methylation on the association between prenatal exposure to the famine and adult WC and BMI. The results showed that prenatal famine exposure was significantly associated with higher overall methylation level of the INSR gene ( d = 3.6%; 95% CI 1.2–6.0; P = 0.027) and larger adulthood WC ( d = 2.72 cm; 95% CI 0.20–5.24; P = 0.034). Furthermore, famine significantly increased methylation levels at four CpG sites. Methylation of the CpG7 site mediated 32.0% (95% CI 5.0–100.0%, P = 0.029) of the association between prenatal exposure to the Chinese great famine and adulthood WC. In conclusion, Epigenetic changes to the INSR might mediate the adverse effect of prenatal famine exposure on WC in adulthood.

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“…WHtR, another widely used traditional anthropometric index, is superior to BMI and WC in the assessment of central obesity (10)(11)(12)29). As a simple and effective anthropometric index, it has been recommended by many scholars as a screening tool for cardiometabolic risk factors.…”

Section: Discussionmentioning

confidence: 99%

Novel and traditional anthropometric indices for identifying metabolic syndrome in non-overweight/obese adults

Zhu

Qiao

et al. 2020

Preprint

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Background: Metabolic syndrome (MetS) in non-overweight/obese people is insidiously associated with cardiovascular disease (CVD). Novel anthropometric indices can reflect central obesity better than the traditional anthropometric indices. Therefore, we hypothesize that these newly developed anthropometric indices can better identify MetS in non-overweight/obese people than conventional indices.Methods: Cross-sectional data of sociodemographic, biochemical and anthropometric indices were collected from 2916 non-overweight/obese Chinese people. A body shape index (ABSI), body roundness index (BRI), waist-to-height ratio (WHtR), weight-adjusted-waist index (WWI) and abdominal volume index (AVI) were calculated. Partial correlation analysis was used to clarify the correlation between anthropometric indices and MetS variables. Binary logistic regression analysis was applied to assess the association between anthropometric indices and MetS and its components. Receiver-operating characteristic (ROC) curve was used to identify the diagnostic ability of anthropometric indices for MetS and its components. The area under curve (AUC) difference between WHtR and each new anthropometric index was compared in pairs.Results: After adjusting for covariates, AVI had the optimal ability of identifying MetS (AUC: 0.743 for male, 0.819 for female) and the strongest correlation with high-density lipoprotein cholesterol (HDL-C) (coe: -0.227 for male, -0.207 for female) and the highest odds rations (OR) with low HDL-C group (male: OR = 1.37, female: OR = 1.55). The WHtR was comparable to BRI in assessing MetS (AUC: 0.739 for male, 0.817 for female). WHtR or BRI could also well identify hypertension (AUC: 0.602 for male, 0.688 for female) and dysglycemia (AUC: 0.669 for male, 0.713 for female) and female's high triglyceride level (AUC 0.712). The recognition ability of the two was equivalent. The ability of ABSI and WWI to identify MetS was weak.Conclusions: AVI is the optimal anthropometric indices to identify MetS in non-overweight/obese Chinese adults. BRI and WHtR can also be considered as discriminators, while ABSI and WWI are weak discriminators. WHtR is easy to measure. So, it is recommended as an early preliminary screening method for the MetS in non-overweight/obese people.

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Anthropometric Indicators of Adiposity Related to Body Weight and Body Shape as Cardiometabolic Risk Predictors in British Young Adults: Superiority of Waist-to-Height Ratio

Cited by 48 publications

References 160 publications

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

DNA methylation of the INSR gene as a mediator of the association between prenatal exposure to famine and adulthood waist circumference

Novel and traditional anthropometric indices for identifying metabolic syndrome in non-overweight/obese adults

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