DNA methylation of the INSR gene as a mediator of the association between prenatal exposure to famine and adulthood waist circumference

Wang, Zhenghe; Song, Jun‐Yeob; Li, Changwei; Li, Yanhui; Shen, Luqi; Dong, Bin; Zou, Zhiyong; Ma, Jun

doi:10.1038/s41598-020-69120-w

Cited by 12 publications

(9 citation statements)

References 33 publications

(36 reference statements)

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“…More recently, Tobi et al demonstrated that DNA methylation mediated the association between prenatal famine exposure with adult BMI and triglycerides [62]. Similar observations of maternal famine exposure on changes in DNA methylation in the offspring were also reported in other studies [63][64][65][66].…”

Section: Nutrition and Dna Methylationsupporting

confidence: 66%

Epigenetics in Precision Nutrition

2022

JPM

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Precision nutrition is an emerging area of nutrition research, with primary focus on the individual variability in response to dietary and lifestyle factors, which are mainly determined by an individual’s intrinsic variations, such as those in genome, epigenome, and gut microbiome. The current research on precision nutrition is heavily focused on genome and gut microbiome, while epigenome (DNA methylation, non-coding RNAs, and histone modification) is largely neglected. The epigenome acts as the interface between the human genome and environmental stressors, including diets and lifestyle. Increasing evidence has suggested that epigenetic modifications, particularly DNA methylation, may determine the individual variability in metabolic health and response to dietary and lifestyle factors and, therefore, hold great promise in discovering novel markers for precision nutrition and potential targets for precision interventions. This review summarized recent studies on DNA methylation with obesity, diabetes, and cardiovascular disease, with more emphasis put in the relations of DNA methylation with nutrition and diet/lifestyle interventions. We also briefly reviewed other epigenetic events, such as non-coding RNAs, in relation to human health and nutrition, and discussed the potential role of epigenetics in the precision nutrition research.

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Section: Nutrition and Dna Methylationsupporting

confidence: 66%

Epigenetics in Precision Nutrition

2022

JPM

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“…Genome-wide screening has revealed differential methylation of expression pathways regulating growth and metabolism in particular in those exposed to the famine during early gestation [25][26][27]. Similar epigenetic relationships have also been found in adults exposed to the Chinese famine [28,29].…”

Section: Human Peri-conception Undernutrition and Offspring Healthmentioning

confidence: 60%

Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk

Fleming

Sun

Denisenko

et al. 2021

IJERPH

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Environment around conception can influence the developmental programme with lasting effects on gestational and postnatal phenotype and with consequences for adult health and disease risk. Peri-conception exposure comprises a crucial part of the ‘Developmental Origins of Health and Disease’ (DOHaD) concept. In this review, we consider the effects of maternal undernutrition experienced during the peri-conception period in select human models and in a mouse experimental model of protein restriction. Human datasets indicate that macronutrient deprivation around conception affect the epigenome, with enduring effects on cardiometabolic and neurological health. The mouse model, comprising maternal low protein diet exclusively during the peri-conception period, has revealed a stepwise progression in altered developmental programming following induction through maternal metabolite deficiency. This progression includes differential effects in extra-embryonic and embryonic cell lineages and tissues, leading to maladaptation in the growth trajectory and increased chronic disease comorbidities. The timeline embraces an array of mechanisms across nutrient sensing and signalling, cellular, metabolic, epigenetic and physiological processes with a coordinating role for mTORC1 signalling proposed. Early embryos appear active participants in environmental sensing to optimise the developmental programme for survival but with the trade-off of later disease. Similar adverse health outcomes may derive from other peri-conception environmental experiences, including maternal overnutrition, micronutrient availability, pollutant exposure and assisted reproductive treatments (ART) and support the need for preconception health before pregnancy.

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“…In people prenatally exposed to this famine, increased methylation level of INSR gene involved in growth and metabolism has been found in late adulthood [ 39 ]. More recently, prenatal Chinese famine exposure was found to be significantly associated with higher overall methylation level of INSR gene and larger adulthood waist circumference [ 40 ]. From these and other findings, it has been suggested that early-life exposure to the Chinese famine can be an important contributor to current epidemics of T2D in China [ 27 , 41 ].…”

Section: Epigenetic Memory Of Prenatal Famine Exposurementioning

confidence: 99%

Prenatal famine exposure and adult health outcomes: an epigenetic link

Vaiserman

Lushchak

2021

Environmental Epigenetics

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Numerous human chronic pathological conditions depend on epigenetic modifications induced by environmental triggers throughout sensitive stages early in development. Developmental malnutrition is regarded as one of the most important risk factors in these processes. We present an overview of studies that the initiation and progression of many diseases are largely dependent on persisting epigenetic dysregulation caused by environmental insults early in life. For particular disorders, candidate genes were identified that underlie these associations. The current study assessed the most convincing evidence for the epigenetic link between developmental malnutrition and adult-life disease in the human population. These findings were obtained from quasi-experimental studies (so-called ‘natural experiments’), i.e. naturally occurring environmental conditions in which certain subsets of the population have differing levels of exposure to a supposed causal factor. Most of this evidence was derived on the DNA methylation level. We discussed DNA methylation as a key player in epigenetic modifications that can be inherited through multiple cell divisions. In this Perspective article, an overview of the quasi-experimental epidemiological evidence for the role of epigenetic mechanisms in the developmental programming by early-life undernutrition is provided.

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DNA methylation of the INSR gene as a mediator of the association between prenatal exposure to famine and adulthood waist circumference

Cited by 12 publications

References 33 publications

Epigenetics in Precision Nutrition

Epigenetics in Precision Nutrition

Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk

Prenatal famine exposure and adult health outcomes: an epigenetic link

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