Anthropometric and Nutritional Parameters in Egyptian Children and Adolescents with Osteogenesis Imperfecta

Abstract

Background/Aims: Patients with osteogenesis imperfecta (OI) present with various degrees of short stature and nutritional disorders. Thus, we aimed to evaluate anthropometric and nutritional parameters in OI children and their variability among various types. Methods: Eighty-four patients with OI (types I, II, and IV) were subjected to the following anthropometric measurements: standing height (Ht), sitting height (SH), arm span, weight (Wt), and head circumference (HC), with calculation of Ht, SH, Wt, body mass index (BMI), and HC standard deviation scores (SDSs), and relative arm span. Triceps skinfold thickness (TSFT), subscapular skinfold thickness (SSFT), and mid upper arm circumference (MUAC) were measured, as well as dietary intake of macronutrients and calcium; also, energy requirements were calculated. Results: Ht SDS was reduced in OI-III and OI-IV compared to OI-I; SH SDS was reduced in OI-III compared to OI-I. HC SDS was more increased in OI-III than in OI-I and OI-IV. BMI SDS correlated with TSFT, SSFT, and MUAC. OI-III patients had the highest percentage of energy intake. The frequency of low macronutrient and calcium intake was highest in OI-III, while the frequency of low fat intake was highest in OI-I. Conclusions: Anthropometric and nutritional parameters differ among OI types. Assessment of anthropometric measurements and nutritional status in OI patients is important.

Anthropometrics of Polish children with osteogenesis imperfecta: a single-centre retrospective cohort study

“…In our study, we demonstrated a significant difference between type I, in which the median height percentile was 21, and type III, with a median height percentile of 0.1 (p < 0.001). Our observations are consistent with the results presented in the literature [ 15 , 16 , 19 , 20 ]. The growth deficiency results presumably from the high number of fractures and associated deformities, which may lead to an abnormal osteoblast response to growth factors.…”

Growth and Pubertal Features in a Cohort of 83 Patients with Osteogenesis Imperfecta

“…Furthermore, we demonstrated that the frequency of being overweight and particularly obesity increased throughout the follow-up period (from 13.2 to 14.2 % and from 6 to 11.7 %, respectively). In the same vein, Hamza et al reported that 11.9 % and 7.14 % of their 84 patients with OI were overweight and obese, respectively [13]. Fano et al observed that 19 % of their 65-patient cohort were overweight, and 11 % were obese [11].…”