Anthraquinones

Fouillaud, Mireille; Caro, Yanis; Venkatachalam, Mekala; Grondin, Isabelle; Dufossé, Laurent

doi:10.1201/9781315120157-9

Cited by 23 publications

(27 citation statements)

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“…Phytochemical screening of the ethanol extracts of the plants (Table 1) [13]. But overall, it could be seen that the essential phytoconstituents that gives vegetables their nutritional as well as health benefits are well distributed in the plants investigated.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Potential of Selected Nigerian Vegetables

Hassan

Barde

2019

Int. Ann. Sci.

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Reducing power activities of ten vegetables commonly consumed in Katsina State, Nigeria have been assessed with the view of establishing their antioxidant capacities. Preliminary, the phytochemicals of the individual plants were screened, and it was found that various constituents were present. In particular, flavonoids and anthraquinones were found in Ficus glumosa which also appeared to demonstrate the best reducing power activity (4.898 at 25 mg/L).

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Section: Resultsmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Potential of Selected Nigerian Vegetables

Hassan

Barde

2019

Int. Ann. Sci.

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“…Use of AQ in the European Union is currently restricted (as cited in Fouillaud, Caro, Venkatachalam, Grondin, & Dufossé, 2018). Early tests found AQ to be mutagenic and carcinogenic (National Toxicology Program, 1999).…”

Section: Discussionmentioning

confidence: 99%

Applying hierarchical resource selection concepts to solving crop damage caused by birds

Barzen

Gossens

Lacy

et al. 2020

Conservat Sci and Prac

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Recovery of Greater Sandhill Cranes (Grus canadensis tabida) is a conservation success but will increase the potential for crop damage if problems caused by high crane density remain unresolved. In spring, cranes consume planted corn kernels (Zea mays), causing significant damage. From 1999 to 2001 and 2007 to 2009 we experimented with resolving crane damage. Seeds treated with either insecticides or anthraquinone (AQ) were not consumed in planted fields while untreated seeds were, causing a 19.6% reduction in seedling density where cranes foraged. Insecticides tested were inappropriate for future use while performance of AQ mimicked that of insecticides but was environmentally acceptable and economical to use. Though cranes selected germinating corn fields, regardless of treatment, they used fields containing treated corn without causing damage. Cranes were generalists when selecting food items within a field and likely switched food items when exposed to treated corn but were specialists when selecting field types within a home range. Deterrence at geographic scales where species are generalists may reduce the chance for habituation. Subsequent deployment of AQ has been replicated with other bird species and crops at landscape scales. Successful solutions enable landowners to value wildlife and promote biological diversity found on those lands.

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“…Studies have shown that naturally occurring AQs exist either as aglycans or bound to sugars, forming water-soluble glycosides (Caro et al, 2012;Wu, Wang, Liu, Niu, & Wu, 2017;Fouillaud et al, 2018). Wu, Wang, Liu, Niu, and Wu (2017) have shown that AQs isolated from rhubarb, except for rhein majorly exist as glycosides.…”

Section: Pharmacokinetics Of Aqsmentioning

confidence: 99%

“…The AQs and derivatives are the class of commonly available tricyclic aromatic quinones containing anthracenedione or 9,10‐dioxoanthracenecore and can exist in several possible isomeric forms (Figure ). AQs occur naturally in plants, lichens, insects, and fungi as glycosides and free aglycones with various biological activities such as anticancer (Fouillaud, Caro, Venkatachalam, Grondin, & Dufossé, ; Müeller et al, ), antioxidant (Yen, Duh, & Chuang, ), and antibacterial (Comini et al, ). For decades, compounds with AQ backbone have been exploited and used as drugs.…”

Section: Introductionmentioning

confidence: 99%

“…The bioactivity of the AQs depends entirely on the nature and the position of the substituents, mainly, hydroxyl, alkoxy, alkyl, and sugar units attached to positions R1–R8 on the anthracenedione moiety. Studies have shown that AQs are effective against DM and its complications and act on different antidiabetic targets, suggesting their potential as antidiabetic candidates (Dong et al, ; Fouillaud et al, ; Qi et al, ; Yen et al, ). However, for therapeutic application, obtaining a comprehensive view of their antidiabetic effects vis‐à‐vis the structural–activity relationship and possible mechanism of actions are of interest for effective drug design.…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic potential of anthraquinones: A review

Mohammed

Ibrahim

Tajuddeen

et al. 2019

Phytotherapy Research

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The present study was designed to review the antidiabetic potential of anthraquinones (AQs) with emphasis on the extent of blood glucose reduction, the half maximal inhibitory concentration values (in vitro studies), the proposed mechanisms of action, and the structure activity relationship studies. We sourced relevant data from the major scientific databases (Pubmed, Science Direct, Medline, and Google Scholar). According to our search, 25 AQs have shown variable antidiabetic potential, whereas one AQ (morindone‐6‐O‐β‐D‐primeveroside) showed no blood glucose‐lowering ability. Emodin and rhein showed the most promising antidiabetic potential in various models. The proposed mechanisms of antidiabetic action include upregulation of insulin receptor substrates‐1, phosphoinositide‐3‐kinase, and Akt‐ser473 expression and elevation of glucagon‐like peptide‐1 level in diabetic animal models linked to the potent protein tyrosine phosphatase 1B and dipeptidyl peptidase‐4 inhibitions. In addition, activation of peroxisome proliferator‐activated receptors gamma and inhibition of α‐glucosidase activity are other possible targets proposed as the mechanism of AQs antidiabetic action. The position and the number of hydroxyl group showed great influence on the overall antidiabetic potential of AQs. AQs hold promising antidiabetic activity despite scanty information. We hope that the present study will serve as a template to further explore the antidiabetic potential of AQs and subsequent antidiabetic drug development.

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Anthraquinones

Cited by 23 publications

References 1 publication

Phytochemical Screening and Antioxidant Potential of Selected Nigerian Vegetables

Phytochemical Screening and Antioxidant Potential of Selected Nigerian Vegetables

Applying hierarchical resource selection concepts to solving crop damage caused by birds

Antidiabetic potential of anthraquinones: A review

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