Phytochemical Screening and Antioxidant Potential of Selected Nigerian Vegetables

Hassan, Yusuf; Barde, Magaji Ilu

doi:10.21467/ias.8.1.12-16

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Alkaloids, glycosides, flavonoids, steroids, tannins, and phenols were identified in the preliminary phytochemical screening of khat (Catha edulis) leaf extract. Standard procedures were used to identify these phytochemical constituents based on color changes (Figure 5) [48,49]. Table 1 shows the results of a qualitative phytochemical investigation of khat (Catha edulis) leaf extract.…”

Section: Antibacterial Activity Of Zno Nps Using Disc Diffusionmentioning

confidence: 99%

Khat (Catha edulis) Leaf Extract‐Based Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial Activity

Aklilu

Aderaw

2022

Journal of Nanomaterials

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In this study, we used khat (Catha edulis) leaf extract as a reducing and stabilizing agent for the biosynthesis of zinc oxide nanoparticles (ZnO NPs). The rapid color change of the solution to pale yellow and UV-visible absorption peak at 322 nm confirmed the initial formation of ZnO NPs. FTIR spectrum analysis revealed the contribution of khat leaf extract to the bioreduction of Zn2+ ions to ZnO NPs. The FTIR spectrum for the stretching vibration of ZnO at 480 cm-1 also confirms the formation of ZnO NPs. The XRD spectrum showed the crystallinity and the hexagonal wurtzite structure of ZnO NPs. The size of the synthesized ZnO NPs calculated using the Debye-Scherrer formula was found to be equal to 17 nm. Antibacterial efficacy of green-produced zinc oxide nanoparticles against Gram-positive and Gram-negative microorganisms was tested. It has the greatest inhibition zone (23 mm) against E. coli, but the least activity was against S. pneumoniae (15 mm).

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Section: Antibacterial Activity Of Zno Nps Using Disc Diffusionmentioning

confidence: 99%

Khat (Catha edulis) Leaf Extract‐Based Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial Activity

Aklilu

Aderaw

2022

Journal of Nanomaterials

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Comparing the Neuroprotective Effects of Aqueous and Methanolic Extracts of Vernonia Amygdalina on the Cerebellum of Adult Male Wistar Rats

Aguwa

Okeke

et al. 2020

Int. Ann. Sci.

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The solvent of extraction determines the type and amount of phytochemicals extractible from a plant material. Reports have shown that numerous African herbs are rich is potent phytochemicals which have been used in folkloric and orthodox medicine in the prevention and treatment of ailments. This research is geared towards comparing the neuroprotective potency of the aqueous and methanolic extracts of Vernonia amygdalina on the cerebellum of mercury chloride intoxicated Wistar rats. Thirty adult male Wistar rats were divided into 6 groups of 5 rats each. Group A was the negative control and had food and water only. Group B was the positive control and was exposed to mercury chloride without treatment. Groups C1 and C2 received 200mg/kg bw of aqueous and methanolic extracts respectively while groups D1 and D2 received 400mg/kg bw of aqueous and methanolic extracts of Vernonia amygdalina respectively. Result of phytochemical analysis shows that water extracted more flavonoids while methanol extracted more phenols. The results of antioxidant studies show that the methanolic extract conferred more protection against oxidative stress than the aqueous extract. Histological results show that aqueous extract conferred more protection than the methanolic extract. We therefore conclude from our report that both the aqueous and methanolic extracts of Vernonia amygdalina confer neuroprotection on the cerebellum of Wistar rats.

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Antioxidant and Antiproliferative Potentials of Ficus glumosa and Its Bioactive Polyphenol Metabolites

et al. 2021

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Ficus glumosa Delile (Moraceae), a reputed plant that is used in herbal medicine, is of high medicinal and nutritional value in local communities primarily ascribed to its phytochemical profile. Currently, there are hardly any fine details on the chemical profiling and pharmacological evaluation of this species. In this study, the flavonoids and phenolics contents of the ethanol extracts and four extracted fractions (petroleum ether (PE), ethyl acetate (EA), n-butanol, and water) of the stem bark of Ficus glumosa were firstly quantified. Further, their antioxidant and antiproliferative potentials were also evaluated. The quantitative determination indicated that the EA and n-butanol fractions possessed the highest total flavonoids/phenolics levels of 274.05 ± 0.68 mg RE/g and 78.87 ± 0.97 mg GAE/g, respectively. Similarly, for the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric-reducing antioxidant power (FRAP) assays, the EA fraction exhibited high potency in both DPPH and ABTS+ scavenging activities with IC50 values of 0.23 ± 0.03 mg/mL, 0.22 ± 0.03 mg/mL, and FRAP potential of 2.81 ± 0.01 mg Fe2+/g, respectively. Furthermore, the EA fraction displayed high cytotoxicity against human lung (A549) and colon (HT-29) cancer cells. Additionally, the liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was employed in order to characterize the chemical constituents of the EA fraction of Ficus glumosa stem bark. Our findings revealed 16 compounds from the EA fraction that were possibly responsible for the strong antioxidant and anti-proliferative properties. This study provides edge-cutting background information on the exploitation of Ficus glumosa as a potential natural antioxidant and anti-cancer remedy.

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Phytochemical Screening and Antioxidant Potential of Selected Nigerian Vegetables

Cited by 3 publications

References 14 publications

Khat (Catha edulis) Leaf Extract‐Based Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial Activity

Khat (Catha edulis) Leaf Extract‐Based Zinc Oxide Nanoparticles and Evaluation of Their Antibacterial Activity

Comparing the Neuroprotective Effects of Aqueous and Methanolic Extracts of Vernonia Amygdalina on the Cerebellum of Adult Male Wistar Rats

Antioxidant and Antiproliferative Potentials of Ficus glumosa and Its Bioactive Polyphenol Metabolites

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