Anthraquinone ß-D-glucoside from Cassia grandis

Verma, Rajeshwar P.; Sinha, Kunal

doi:10.1076/phbi.34.4.290.13228

Cited by 4 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous phytochemical studies were mainly performed on C. fistula and the two Senna species and have mainly reported the isolation of anthraquinones, anthranoides, anthrones, and flavonoids [ 7 ]. Few studies report the chemical constituents of C. grandis including the isolation of aloe-emodin from the leaf [ 22 ], 1,3,4-trihydroxy-6,7,8-trimethoxy-2-methyl anthraquinone-3-O-β-D- Glucopyranoside from the pod [ 23 ], and emodin-9-anthrone from the stem [ 24 ]. However, it is worth mentioning that this is the first detailed study on the phenolic profiles of these four species and this untargeted metabolomics approach would enable us to identify the composition of extracts to integrate biological knowledge, and, consequently, pinpoint pharmaceutical candidates [ 2 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

et al. 2022

View full text Add to dashboard Cite

Several species within the genera Cassia or Senna have a treasure of traditional medicines worldwide and can be a promising source of bioactive molecules. The objective of the present study was to evaluate the phenolic content and antioxidant and enzyme inhibition activities of leaf methanolic extracts of C. fistula L., C. grandis L., S. alexandrina Mill., and S. italica Mill. The two Cassia spp. contained higher total polyphenolic content (42.23–49.75 mg GAE/g) than the two Senna spp., and C. fistula had significantly (p ˂ 0.05) the highest concentration. On the other hand, the Senna spp. showed higher total flavonoid content (41.47–59.24 mg rutin equivalent per g of extract) than that found in the two Cassia spp., and S. alexandrina significantly (p ˂ 0.05) accumulated the highest amount. HPLC–MS/MS analysis of 38 selected bioactive compounds showed that the majority of compounds were identified in the four species, but with sharp variations in their concentrations. C. fistula was dominated by epicatechin (8928.75 µg/g), C. grandis by kaempferol-3-glucoside (47,360.04 µg/g), while rutin was the major compound in S. italica (17,285.02 µg/g) and S. alexandrina (6381.85). The methanolic extracts of the two Cassia species exerted significantly (p ˂ 0.05) higher antiradical activity, metal reducing capacity, and total antioxidant activity than that recorded from the two Senna species’ methanolic extracts, and C. fistula displayed significantly (p ˂ 0.05) the highest values. C. grandis significantly (p ˂ 0.05) exhibited the highest metal chelating power. The results of the enzyme inhibition activity showed that the four species possessed anti-AChE activity, and the highest value, but not significantly (p ≥ 0.05) different from those obtained by the two Cassia spp., was exerted by S. alexandrina. The Cassia spp. exhibited significantly (p ˂ 0.05) higher anti-BChE and anti-Tyr properties than the Senna spp., and C. grandise revealed significantly (p ˂ 0.05) the highest values. C. grandise revealed significantly (p ˂ 0.05) the highest α- amylase inhibition, while the four species had more or less the same effect against the α-glucosidase enzyme. Multivariate analysis and in silico studies showed that many of the identified phenols may play key roles as antioxidant and enzyme inhibitory properties. Thus, these Cassia and Senna species could be a promising source of natural bioactive agents with beneficial effects for human health.

show abstract

Section: Resultsmentioning

confidence: 99%

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Purgative 64 Treatment of skin diseases 64 Treatment of epistaxis 65 Treatment of anemia 66 Treatment of cold 65 Treatment of liver disorder 67 Treatment of urinary disorder 67 Treatment of anemia 66 Treatment of epistaxis 65 Treatment of cold 65 Treatment of liver disorder 67 Treatment of urinary disorder 67 Seed Laxative 64,[68][69][70] Bark Wound healing 71 Treatment of rheumatism 67 Treatment of anemia 66 Treatment of epistaxis 65 Treatment of cold 65 Treatment of liver disorder 67 Treatment of urinary disorder 67 Root Wound healing 67 Treatment of cold 67 Treatment of skin diseases 67 C. javanica Leaf Treatment of Herpes zoster 72 Treatment of bad breath 73 Treatment of cold 75 Treatment of gastric pain 75 Treatment of measles 75 Antimalarial 75 Pod Laxative 76 Treatment of cold 76 Bark Antidiabetic 72 C. alata Leaf Laxative 1,40 Analgesic 77…”

Section: Cassia Fistulamentioning

confidence: 99%

Microscopic and molecular authentication of selected cassia species endemic to Thailand and evaluation of aloe-emodin contents in cassia garrettiana and cassia grandis leaves

Sihanat

View full text Add to dashboard Cite

The genus Cassia L, belongs to the Caesalpiniaceae family, has been widely used as herbs, foods and ornamental plants for a long time. Due to the similar morphology and vernacular name, the identification of these species is perplexed. This study aimed to distinguish 16 Cassia spp. existing in Thailand using macroscopic examination, microscopic examination and AFLP fingerprinting as well as the quantitative analysis of aloe-emodin contents in C. garrettiana and C. grandis leaves collected from 15 different locations in Thailand was also developed and validated using thin-layer chromatography densitometry and thin-layer chromatography image analysis with ImageJ software. The macroscopic characteristics and transverse section of leaf through midrib were illustrated by drawing. Transverse section of leaf through midrib observed under the light microscope showed the anatomical characteristics of epidermis, palisade cells, spongy cells, vascular bundle, parenchyma and collenchyma. Leaf trichome characteristic and number observed under the light microscope and scanning electron microscopy showed the uniseriate, uni- or multicellular non-glandular and multicellular glandular trichome. However, some Cassia spp. had absent of trichome. Cassia javanica L. had the highest trichome number in both dorsal (78.94±2.86) and ventral (127.39±2.46) surfaces of the leaf whereas Cassia surattensis Burm. f. had the lowest trichome number found only on ventral (3.46±0.80) surface. The AFLP fingerprint among 16 selected Cassia spp. indicated that eleven primer combinations produced a total of distinct and reproducible 849 bands with an average 77.18 bands per primer combinations. The genetic relationship based on amplified AFLP bands showed the similarity index (SI) ranged from 0.25 to 0.78. The quantitative analysis of aloe-emodin contents from 15 sources of Cassia garrettiana Craib and Cassia grandis L. f. using TLC-densitometry with winCATS software and TLC-image analysis with ImageJ software found that C. garrettiana dried crude drug had 0.035±0.007 and 0.035±0.006 g% of aloe-emodin contents whereas in C. grandis dried crude drug had 0.412±0.067 and 0.413±0.075 g% of aloe-emodin contents, respectively. Both methods were developed and validated in term of specificity, linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. The data obtained from this study provided useful information for identification of selected Thai Cassia spp. and provided the aloe-emodin contents in C. garrettiana and C. grandis leaves.

show abstract

The genusCassiaL.: Ethnopharmacological and phytochemical overview

Khurm

Wang

Zhang

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

after first online publication: The funding information and acknowledgement sections have been updated in this version.] Nature gifts medicinal plants with the untapped and boundless treasure of active chemical constituents with significant therapeutic potential that makes these plants a beneficial source in the development of phytomedicines. Genus Cassia, with approximately 500 species, is a large group of flowering plants in the family Fabaceae. Cassia species are widely distributed throughout different regions mainly tropical Asia, North America, and East Africa. In the folk medicinal history, these plants are used as laxative and purgative agents. In the Ayurveda system of medicine, they are used to cure headache and fever. Cassia plants exhibit pharmacological activities at large scales such as antimicrobial, anticancer, antiinflammatory, antioxidant, hypoglycemic, hyperglycemic, antimutagenic, and antivirals. The phytochemical investigations of genus Cassia demonstrate the presence of more than 200 chemical compounds, including piperidine alkaloids, anthracene derivatives (anthraquinones), flavonoids, pentacyclic triterpenoids, sterols, phenylpropanoids, and γ-naphthopyrones. The literature illustrated anthraquinones and flavonoids as major secondary metabolites from this genus. However, some Cassia plants, with rich contents of anthraquinones, still show toxicology properties. As Cassia plants are used extensively in the herbal Abbreviations: AAE, ascorbic acid equivalent; AGEs, advanced glycation end products; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAT, catalase enzyme; CCl4, carbon tetrachloride; CFU, colony forming units; COLO320DM, human colon carcinoma cell line; CRFK, crandell feline kidney cell; DMSO, dimethyl sulfoxide; DPPH, 2,2-diphenyl-1-picrylhydrazyl; EC 50 , half maximal effective concentration; ELISA, enzyme-linked immunosorbent assay; FDA, Food and Drug Administration; GPx, glutathione peroxidase; HCT-116, human colorectal carcinoma cell line; HDL, high-density lipoprotein; HeLa, immortal cell line used in scientific research; HEL, human erythroleukemia cell line; Hep-2, human epithelial type 2 cells; HIV,

show abstract

Anthraquinone ß-D-glucoside from Cassia grandis

Cited by 4 publications

References 12 publications

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

Phenolic Profile, Antioxidant and Enzyme Inhibitory Activities of Leaves from Two Cassia and Two Senna Species

Microscopic and molecular authentication of selected cassia species endemic to Thailand and evaluation of aloe-emodin contents in cassia garrettiana and cassia grandis leaves

The genusCassiaL.: Ethnopharmacological and phytochemical overview

Contact Info

Product

Resources

About