Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial

Rosario, Vinicius A. do; Chang, Courtney R.; Spencer, Jaclyn; Alahakone, Thilani; Roodenrys, Steven; François, Monique E.; Weston–Green, Katrina; Hölzel, Nadine; Nichols, David S.; Kent, Katherine; Williams, David; Wright, Ian; Charlton, Karen E

doi:10.1016/j.clnu.2020.09.041

Cited by 29 publications

(40 citation statements)

References 78 publications

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“…In another study, sixteen volunteers were subjected to the consumption of a 250 mL dose of anthocyanin-rich plum juice; the results obtained revealed a decrease in the C-protein reactive, IL-6, IL-1 β , and TNF- α concentrations of−22, −7, −9 and −4%, respectively. These data were observed 4 h after the intake relative to the placebo group [ 165 ].…”

Section: Putative Health Benefitsmentioning

confidence: 99%

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

et al. 2021

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In recent years, the consumption of natural-based foods, including beans, fruits, legumes, nuts, oils, vegetables, spices, and whole grains, has been encouraged. This fact is essentially due to their content in bioactive phytochemicals, with the phenolic compounds standing out. Among them, anthocyanins have been a target of many studies due to the presence of catechol, pyrogallol, and methoxy groups in their chemical structure, which confer notable scavenging, anti-apoptotic, and anti-inflammatory activities, being already recommended as supplementation to mitigate or even attenuate certain disorders, such as diabetes, cancer, and cardiovascular and neurological pathologies. The most well-known anthocyanins are cyanidin 3-O-glucoside and cyanidin 3-O-rutinoside. They are widespread in nature, being present in considerable amounts in red fruits and red vegetables. Overall, the present review intends to discuss the most recent findings on the potential health benefits from the daily intake of anthocyanin-rich foods, as well as their possible pharmacological mechanisms of action. However, before that, some emphasis regarding their chemical structure, dietary sources, and bioavailability was done.

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Section: Putative Health Benefitsmentioning

confidence: 99%

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

et al. 2021

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“…To date, a substantial number of human studies and metaanalyses have discussed the preventive effects of (poly)phenolcontaining foods against cardiometabolic diseases and, to a lesser extent, against some types of cancer and neurodegenerative diseases. [22][23][24][25][26][27][28][29][30][31][32][33] However, there is controversy and not all the studies reach conclusive links between (poly)phenols and health, even for the same outcome, e.g., vascular function, performed by the same research group and assaying the same pure flavonoid, e.g. epicatechin.…”

Section: Introductionmentioning

confidence: 99%

Main drivers of (poly)phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

et al. 2021

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“…A total of 12 of the 36 included studies were randomized controlled trials [33,34,37,41,43,50,56,57,[59][60][61]67], 8 were cross-sectional studies [36,39,40,44,45,49,51,58], 6 were prospective cohort studies [32,47,55,[63][64][65], 4 were cohort studies [46,52,62,66], 2 were crossover studies [38,53], 2 were randomized non-controlled trials [35,42], and 2 were prospective non-randomized: pre/post studies [48,54]. Telomere length (TL) was measured using saliva samples and ultra-processed food (UPF) consumption was collected using a validated 136-item food frequency questionnaire (FFQ); the association between consumption of energy-adjusted UPF and the risk of having short telomeres was evaluated using logistic regression models.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Nutrition on Aging—A Systematic Review Focusing on Aging-Related Biomarkers

et al. 2022

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Despite the increasing life expectancy, an individual’s later years tends to be accompanied by a decrease in the quality of life. Though biological changes that occur through the natural process of aging cannot be controlled, the risk factors associated with lifestyle can. Thus, the main goal of this systematic review was to evaluate how nutrition can modulate aging. For this purpose, thirty-six studies were selected on (i) the efficiency of nutrition’s effect on aging, (ii) the evaluation of biomarkers that promote healthy aging, and (iii) how to increase longevity through nutrition, and their quality was assessed. The results showed that choosing low carbohydrate diets or diets rich in vegetables, fruits, nuts, cereals, fish, and unsaturated fats, containing antioxidants, potassium, and omega-3 decreased cardiovascular diseases and obesity risk, protected the brain from aging, reduced the risk of telomere shortening, and promoted an overall healthier life. With this study, the conclusion is that since the biological processes of aging cannot be controlled, changing one’s nutritional patterns is crucial to prevent the emergence and development of diseases, boost longevity, and, mostly, to enhance one’s quality of life and promote healthy aging.

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Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial

Cited by 29 publications

References 78 publications

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

Main drivers of (poly)phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

The Effect of Nutrition on Aging—A Systematic Review Focusing on Aging-Related Biomarkers

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