Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

Arjinajarn, Phatchawan; Chueakula, Nuttawud; Pongchaidecha, Anchalee; Jaikumkao, Krit; Chatsudthipong, Varanuj; Mahatheeranont, Sugunya; Norkaew, Orranuch; Chattipakorn, Nipon; Lungkaphin, Anusorn

doi:10.1016/j.biopha.2017.05.100

Cited by 57 publications

(61 citation statements)

References 39 publications

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“…Khaksari and coauthors showed that GM directly enhanced apoptosis and oxidative stress in the liver of rats. Arjinajarn and coauthors [50] and Mohamadi Yarijani and coauthors [8] reported that GM induced increased AST, ALT, and ALP activities, elevated ROS and LPO productions, enhanced mitochondrial activated apoptosis and intensified liver histopathological damages. In our results, we similarly found a marked elevation in liver function parameters in GM treated rats, showing that liver injuries were induced during GM administration.…”

Section: Discussionmentioning

confidence: 99%

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Ahmadvand

Nouryazdan

Nasri

et al. 2020

Braz. arch. biol. technol.

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Gallic acid (GA), as a strong antioxidant, was selected in this study to investigate its possible nephroprotective effects against gentamicin (GM)-induced nephrotoxicity. Twenty-four rats were separated into three groups (n=8): group 1 (control group) received saline (0.5 mL/day), group 2 (GM group) received GM (100 mg/kg/day), and group 3 (treated group) received GM (100 mg/kg/day) and GA (100mg/kg/day). All treatments were performed intraperitoneally for 12 days. After 12 days, the rats were euthanized, and kidneys were removed immediately. For serum preparation, blood samples were collected before killing. Kidney paraffin sections were prepared from one of the kidneys and stained by the periodic acid-Schiff process. GA significantly decreased GM-induced renal histopathological injuries, including tubular necrosis, tubular cast, and leucocyte infiltration compared with the GM group. Additionally, GA significantly improved proteinuria, serum levels of urea and creatinine, and serum activities of aspartate aminotransferase (AST) and alanine HIGHLIGHTS  Gallic acid ameliorates gentamicin-induced nephrotoxicity.  Gallic acid decreases levels of NO and MDA and enhances abilities of GSH, GPX, and CAT.  Gallic acid improves altered liver and renal function markers in nephrotoxic animals.  Gallic acid reduces renal histopathological injuries.  2 Ahmadvand, H.; et al.

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Section: Discussionmentioning

confidence: 99%

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Ahmadvand

Nouryazdan

Nasri

et al. 2020

Braz. arch. biol. technol.

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“…The major anthocyanin identified in the pigment of Riceberry rice was cyanidin-3-O-glucoside and peonidin-3-O-glucoside [13]. Riceberry rice extract has been previously reported as possessing several biological properties, such as antioxidant, anti-advanced glycation-end products (AGEs), anti-inflammatory, and hepatoprotective activities [14,15]. Recent research provides important evidence that the pigment of Riceberry rice influences the key step of carbohydrate digestion and absorption by inhibiting intestinal α-glucosidase and suppressing mRNA expression of sodium-dependent glucose cotransporter 1 (SGLT1) [13].…”

Section: Introductionmentioning

confidence: 99%

Postprandial Glycemia, Insulinemia, and Antioxidant Status in Healthy Subjects after Ingestion of Bread made from Anthocyanin-Rich Riceberry Rice

Chusak

Pasukamonset²,

Chantarasinlapin

2020

Nutrients

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Riceberry rice, a gluten-free grain, contains many nutrient components, including carbohydrates, proteins, certain fatty acids, and micronutrients, as well as bioactive non-nutrient compounds, such as polyphenolic compounds. This study aimed to evaluate the effect of bread made from anthocyanin-rich Riceberry rice on the postprandial glycemic response, glucagon-like peptide-1 (GLP-1), antioxidant status, and subjective ratings of appetite. In the crossover design, 16 healthy participants (six men and 10 women) completed four sessions involving blood collection in the fasting state and at 30, 60, 90, 120, 150, and 180 min after food consumption (50 g of available carbohydrate) in a randomized order: 1) glucose solution, 2) wheat bread (WB), 3) Riceberry rice bread (RRB), and 4) Hom Mali bread (HMB). Consumption of RRB resulted in significantly lower postprandial plasma glucose concentration at 30 and 60 min when compared to HMB. No difference in postprandial glucose concentration between RRB and WB was observed. In addition, postprandial plasma insulin showed a significant decrease in the group which received RRB at 15 and 60 min, as compared to HMB. In comparison with 50 g of glucose, as a reference, the glycemic index (GI) of RRB, WB, and HMB was 69.3 ± 4.4, 77.8 ± 4.6, and 130.6 ± 7.9, respectively. Interestingly, the ferric-reducing ability of plasma (FRAP) level was shown to significantly increase after consumption of RRB. In the meantime, a significant decrease in the postprandial FRAP level was also observed following an intake of WB and HMB. All breads caused increases in the postprandial plasma protein thiol group and had similar effects on hunger, fullness, desire to eat, and satiety ratings. However, consumption of RBB, WB, and HMB did not change plasma GLP-1 and malondialdehyde (MDA) levels when compared to the baseline. The findings suggest that anthocyanin-rich Riceberry rice can be a natural ingredient for gluten-free bread which reduced glycemic response together with improvement of antioxidant status in healthy subjects.

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“…These effects were related to the suppression of both the oxidative pathway regulated by the transcription factor Nrf2 and the inflammatory pathway regulated by NF-κB. The authors proposed that Cy3glc, the major anthocyanin in this extract, is responsible for these antioxidant and anti-inflammatory properties [91]. Moreover, Hou et al found that black rice bran extract, which is rich in anthocyanins (mainly Cy3glc and Pn3glc), protected mice liver intoxicated with carbon tetrachloride (CCl 4 ) [87].…”

Section: Hepatoprotectionmentioning

confidence: 93%

“…The liver plays an important role in the metabolic elimination of drugs and toxic compounds known to cause injury and reduce the function of the liver. Arjinajarn et al [91] observed that rice bran extract (250-1000 mg/kg) rich in Cy3glc and Pn3glc (13.24 and 5.33 mg/g of crude extract, respectively) significantly prevented gentamicin-induced intoxication of the liver. It has been shown that an anthocyanin-rich extract significantly reduced the hepatic malondialdehyde level (a biomarker for oxidized lipids), increased expression of the antioxidant enzyme SOD, and prevented elevation of levels of liver injury markers, namely alanine and aspartate aminotransferase.…”

Section: Hepatoprotectionmentioning

confidence: 99%

Anthocyanins: From the Field to the Antioxidants in the Body

et al. 2020

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Anthocyanins are biologically active water-soluble plant pigments that are responsible for blue, purple, and red colors in various plant parts—especially in fruits and blooms. Anthocyanins have attracted attention as natural food colorants to be used in yogurts, juices, marmalades, and bakery products. Numerous studies have also indicated the beneficial health effects of anthocyanins and their metabolites on human or animal organisms, including free-radical scavenging and antioxidant activity. Thus, our aim was to review the current knowledge about anthocyanin occurrence in plants, their stability during processing, and also the bioavailability and protective effects related to the antioxidant activity of anthocyanins in human and animal brains, hearts, livers, and kidneys.

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Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

Cited by 57 publications

References 39 publications

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Postprandial Glycemia, Insulinemia, and Antioxidant Status in Healthy Subjects after Ingestion of Bread made from Anthocyanin-Rich Riceberry Rice

Anthocyanins: From the Field to the Antioxidants in the Body

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