Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats

Abstract

Abstract-Anthocyanins are secondary plant metabolites responsible for the blue, purple, and red color of many plant tissues. The phenolic structure of anthocyanins conveys marked antioxidant activity in model systems via donation of electrons or hydrogen atoms from hydroxyl moieties to free radicals. Dietary intakes of anthocyanins may exceed 200 mg/day, however, little is known about their antioxidant potency in vivo. Consequently, the aim of this study was to establish whether anthocyanins could act as putative antioxidant micronutrients. Rats were maintained on vitamin E-deficient diets for 12 weeks in order to enhance susceptibility to oxidative damage and then repleted with rations containing a highly purified anthocyanin-rich extract at a concentration of 1 g/kg diet. The extract consisted of the 3-glucopyranoside forms of delphinidin, cyanidin, petunidin, peonidin, and malvidin. Consumption of the anthocyaninrepleted diet significantly improved (p Ͻ .01) plasma antioxidant capacity and decreased (p Ͻ .001) the vitamin E deficiency-enhanced hydroperoxides and 8-Oxo-deoxyguanosine concentrations in liver. These compounds are indices of lipid peroxidation and DNA damage, respectively. Dietary consumption of anthocyanin-rich foods may contribute to overall antioxidant status, particularly in areas of habitually low vitamin E intake.

Hepatoprotective Effects of Purple Potato Extract againstD-Galactosamine-Induced Liver Injury in Rats

“…[8][9][10]27) Ramirez-Tortosa et al reported that anthocyanin-rich extract decreases hepatic lipid peroxidation in vitamin E-depleted rats. 30) In this study, increasing TBARS levels in the liver homogenate were found in GalN-intoxicated rats, consistent with previous results. 8,9,27) In contrast, PPE treatment tends to attenuate the increased TBARS value in the liver homogenate.…”

Effects of Alcoholic Extract of Stem and Aerial Parts of the Alcea angulate Plant on Aorta Atherosclerotic Plaque Formation in Rabbit

“…These diets contain compounds such as antioxidants [25]. Positive effects of consumption of foods containing antioxidants in improving cardiovascular disease have been reported in clinical researches [17].…”

Red cabbage anthocyanins may protect blood plasma proteins and lipids

“…According to Serraino et al [43], ATH-rich blackberry juice, containing cyanidin-3-O-glucoside, is a scavenger of peroxynitrite, exerting a protective effect against endothelial dysfunction and vascular failure. Ramirez-Tortosa et al showed that ATH-rich extracts decreased hepatic lipid peroxidation under oxidative stress conditions in rats [44]. The studies on an anthocyanin aglycone, pelargonidin, performed by Tsuda et al [45] showed that this compound protects tyrosine from undergoing nitration via peroxynitrite scavenging.…”