Anthelmintic resistance

Craig, Thomas M.

doi:10.1016/0304-4017(93)90053-p

Cited by 34 publications

(17 citation statements)

References 60 publications

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“…As the efficacy of anthelmintic treatment is threatened by the development of resistance in parasites (Craig 1993;Jackson 1993), the search for alternative control strategies is becoming more important. One alternative approach is the development of genetically resistant flocks (Stear and Murray 1994;Windon 1990).…”

Section: Introductionmentioning

confidence: 99%

Class I and class II major histocompatibility complex alleles are associated with faecal egg counts following natural, predominantly Ostertagia circumcincta infection

Buitkamp¹,

Filmether

Stear

et al. 1996

Parasitology Research

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During a previous investigation an association was found between major histocompatibility complex (MHC)-DRB1 alleles and faecal egg counts following natural infection predominantly involving Ostertagia circumcincta in a flock of Scottish Blackface sheep. To localise the disease-resistance locus we screened the same flock for an MHC class I microsatellite and a newly developed microsatellite for the DY locus located in the class IIb subregion. Some alleles at both additional loci were associated with resistance to infection. Least-squares analysis of variance indicated that in 6-month-old lambs, substitution of the most common alleles by the alleles associated with resistance would result in an 8- and a 218-fold reduction in faecal egg counts for MHC class I and DY, respectively. These results indicate that genes within the MHC genes play a large and significant role in the development of resistance to a widespread, important and natural parasite.

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Section: Introductionmentioning

confidence: 99%

Class I and class II major histocompatibility complex alleles are associated with faecal egg counts following natural, predominantly Ostertagia circumcincta infection

Buitkamp¹,

Filmether

Stear

et al. 1996

Parasitology Research

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“…For example, infections with intestinal nematodes are a major constraint on animal production [47]. One approach to control the spread of the infection is to establish genetically resistant flocks by breeding; markerassisted selection allows a preselection of animals within conventional breeding programs.…”

Section: Immunoprinting Human and Animal Genomesmentioning

confidence: 99%

Indirect DNA/gene diagnoses via electrophoresis – an obsolete principle?

et al. 1995

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In principle, gene defects can be investigated directly or indirectly via informative polymorphisms in their vicinity. But because many defects are not yet defined molecularly, these inherited diseases can only be diagnosed indirectly via analysis of informative family situations. Since (multiple) mutation analyses, e.g. via DNA sequencing, are time-consuming and expensive, indirect analysis may still be performed initially--particularly in diseases caused by heterogenous mutations. We focus on diagnoses of neurological and (auto)immune diseases by polymerase chain reaction and separation of the DNA fragments via gel electrophoreses. Even after gene defects have been identified, indirect analysis might be necessary, for example in Huntington's chorea. Although this genetic defect has been characterized as a trinucleotide disease, indirect DNA diagnosis is still performed in particular cases for psychological reasons. The causes of autoimmune diseases are multifactorial and the inheritance is complex, involving several genes. Genome-wide screening programs may involve indirect approaches via analyses of polymorphic microsatellites. Large parts of the immunological genome can be covered when 20 or more genes are investigated simultaneously. Thus the genetic bases of autoimmune diseases are disclosed. Microsatellites themselves could have a biological meaning. We therefore discuss also DNA/protein interactions for simple tandem repeats, the major targets for indirect gene diagnoses. Only indirect evidence exists that certain simple repeats influence genomic (in)stability. Taken together, indirect gene diagnoses supplement direct approaches in a variety of different purposes and in combination with standard electrophoresis techniques.

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“…For example infections with intestinal nematodes are a major constraint on animal production (Craig, 1993). For example infections with intestinal nematodes are a major constraint on animal production (Craig, 1993).…”

Section: Indirect Gene Diagnosismentioning

confidence: 99%

Review

Epplen

Mäueler²,

Epplen³

1994

Biological Chemistry Hoppe-Seyler

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Most eukaryotic genomes are characterized by excessively large amounts of non-coding DNA sequences among which redundant (repetitive) elements constitute a sizable portion. The functional role of an abundant subclass of repetitive sequences--simple, tandemly arranged repeats--remained mysterious so far. Even the biological meaning of most of these elements appears quite refractory to present-day techniques in molecular genetics. Notwithstanding simple repetitive sequences have been developed into superb tools for various aspects of eukaryotic genome research: Using oligonucleotide probes carrying simple repeat motifs multilocus DNA fingerprinting can be applied for individual identification and genetic relationship analyses in plants, animals and humans. Microsatellite analyses via polymerase chain reaction of simple repeat blocks allow for efficient investigations of such divers subject matters as criminal stains, detailed genome maps and indirect gene diagnoses.

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Anthelmintic resistance

Cited by 34 publications

References 60 publications

Class I and class II major histocompatibility complex alleles are associated with faecal egg counts following natural, predominantly Ostertagia circumcincta infection

Class I and class II major histocompatibility complex alleles are associated with faecal egg counts following natural, predominantly Ostertagia circumcincta infection

Indirect DNA/gene diagnoses via electrophoresis – an obsolete principle?

Review

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