Anthelmintic activity of steroidal saponins from Paris polyphylla

Wang, Gao‐Xue; Han, Jing; Zhao, L.-W.; Jiang, Dong-Xin; Liu, Y.-T.; Liu, X.-L.

doi:10.1016/j.phymed.2010.04.012

Cited by 135 publications

(75 citation statements)

References 33 publications

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“…The anthelmintic activity of oils or plant extracts has been evaluated mainly against monogenean parasites of goldfish (Carassius auratus) (Steverding et al, 2005;Wang et al, 2009;Wang et al, 2010aWang et al, , 2010bWang et al, , 2011.…”

Section: Introductionmentioning

confidence: 99%

Essential oils of Lippia sidoides and Mentha piperita against monogenean parasites and their influence on the hematology of Nile tilapia

et al. 2016

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This study evaluated the use of therapeutic baths containing essential oils of Lippia sidoides (pepper rosemary) and Mentha piperita (peppermint) on the hematological parameters of Nile tilapia parasitized by the monogeneans Cichlidogyrus tilapiae, Cichlidogyrus thurstonae, Cichlidogyrus halli, and Scutogyrus longicornis. A total of 320 juvenile fish were distributed into 16 tanks of capacity 100 L (20 fish per tank), divided into 4 treatments in quadruplicates: fish exposed to a bath of L. sidoides at 20 mg L −1 ; fish exposed to M. piperita at 40 mg L −1 ; fish exposed only to a water bath; and fish exposed to water + DMSO (dimethyl sulfoxide) bath. The fish were subjected to 3 baths for 10 min, at intervals of 24 h between treatments. After the third bath, parasitological and hematological analyses were performed. The parasite prevalence in fish treated with essential oils was seen to have decreased by 70%. The efficacy attained among fish treated with L. sidoides, in comparison with control water and water + DMSO, was 1.96% and 14.16%, respectively; and among fish treated with M. piperita, it was 33.33% and 41.63%, respectively. The total numbers of red blood cells (RBC) and thrombocytes were lower in fish treated with L. sidoides. Glucose concentration and neutrophil count were significantly higher in fish treated with L. sidoides. Because of the efficacy and positive hematological results, we suggest that baths of M. piperita at 40 mg L −1 should be used as anthelmintic action. Statement of relevance: Authors believe on the use of essential oils to treat ectoparasites of cultured fish and consequently no damages for hematological profile of Nile tilapia were found.

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Section: Introductionmentioning

confidence: 99%

Essential oils of Lippia sidoides and Mentha piperita against monogenean parasites and their influence on the hematology of Nile tilapia

et al. 2016

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“…The current work in our laboratory is focused on screening medicinal plants with promising anthelmintic activity and isolating groups of compounds/pure compounds responsible for the activity. We have previously reported that crude extracts of several traditional medicinal plants, such as Arctium lappa L. ), Dioscorea zingiberensis C. H. Wright (Wang et al 2010a) and Paris polyphylla (Wang et al 2010b) can effectively control the Dactylogyrus intermedius infection in goldfish (Carassius auratus), and some bioactive compounds have further been isolated, including arctigenin, gracillin, dioscin, and so on. Nevertheless, there is still little available information on the use of medical plants for the treatment of Dactylogyrus diseases in fish.…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of anthelmintic potential of medicinal plant extracts against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)

Zhu

Wang

et al. 2010

Parasitol Res

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In the present study, an attempt has been made to petroleum ether, chloroform, ethyl acetate, methanol, and water extracts of Prunus amygdalus Batsch seeds (Semen amygdali), Cimicifuga foetida L. rhizomes (Rhizoma Cimicifugae), Peucedanum decursivum (Miq.) Maxim roots (Radix Peucedani), Momordica cochinchinensis Spreng. seeds (Semen Momordicae), and Bupleurum chinense DC. roots (Radix Bupleuri chinensis) for their in vivo anthelmintic activity against monogenean Dactylogyrus intermedius in goldfish (Carassius auratus). The results showed that the efficacies of methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were found to be, in this order, more effective than others with the 48 h-EC(50) and EC(90) values of 3.5 and 6.9, 6.0 and 8.4, 7.4 and 11.2 mg/L, respectively, followed by ethyl acetate extract of R. cimicifugae and chloroform extract of R. peucedani with EC(50) 189.2 and 240.4 mg/L. The promising methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were subjected to acute toxicity tests for the evaluation of their safety to the host. After 48-h exposure, the mortalities of goldfish were recorded, and the established LC(50) values were 10.1-, 4.2-, and 8.4-fold higher than the corresponding EC(50). These results indicated that the three extracts from R. Bupleuri chinensis exhibit potential to be used as preferred natural antiparasitics for the control of the D. intermedius, especially for the methanolic one.

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“…Flavonoids can interact with the free proteins of gastrointestinal host or glycoproteins on the worm's cuticula and blocking tubulin polymerization causing the worm death [33]. Saponins cause vacuolization and disintegration of the tegumental worm through changing of their cell membrane permeability [34]. Glycosides and steroids are antioxidant agents that decrease nitrate production, it leads to the inhibition of worm development [35].…”

Section: Discussionmentioning

confidence: 99%

The Anthelmintic Effects of Ethanol Extract of Curanga Fel-Terrae Leaves on Ascaridia Galli

Patilaya

Husori

Sumantri

2017

Asian J Pharm Clin Res

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Objective: This study was to investigate the anthelmintic effects of ethanol extract of Curanga fel-terrae leaves on Ascaridia galli.Methods: Extract of C. fel-terrae was prepared by percolating the dried powder of the plant leaves. To observe anthelmintic effects, A. galli was exposed to the plant extract solutions in different concentrations at room temperature for 72 hrs. Sodium chloride 0.9%, sodium carboxymethyl cellulose 0.5%, and albendazole 0.1% were served as negative control, solvent control, and positive control, respectively. The anthelmintic effects were determined by observing the time taken for paralysis and the time taken for death of A. galli during experiment. Results:The results demonstrated that there were no different effects between negative and solvent controls. However, the ethanol extract of C. fel-terrae leaves exhibited significantly paralysis and death effects toward A. galli. The plant extracts at the concentration of 100 mg/ml showed similar anthelmintic effects with albendazole 0.1%. This study also indicated that the paralysis and death effects of plant extract were shorter when the worms exposed with the concentration above of 100 mg/ml. Conclusion:This study indicated that the ethanol extract of C. fel-terrae leaves has potential anthelmintic effects on A. galli.

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Anthelmintic activity of steroidal saponins from Paris polyphylla

Cited by 135 publications

References 33 publications

Essential oils of Lippia sidoides and Mentha piperita against monogenean parasites and their influence on the hematology of Nile tilapia

Essential oils of Lippia sidoides and Mentha piperita against monogenean parasites and their influence on the hematology of Nile tilapia

In vivo evaluation of anthelmintic potential of medicinal plant extracts against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)

The Anthelmintic Effects of Ethanol Extract of Curanga Fel-Terrae Leaves on Ascaridia Galli

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