Anthelmintic activity of praziquantel onRaillietina tetragona in chickens

Nurelhuda, I. E. M.; Elowni, Elsayed E.; Hassan, T.

doi:10.1007/bf00930965

Cited by 6 publications

(5 citation statements)

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“…Cestodes recovery methods involving only content collection and mucosal scraping (Nurelhuda et al, 1989;Yazwinski et al, 1992;2003;Silva et al, 1999;Vich Topic GL21, 2001;Tucker et al, 2007;Alam et al, 2014;Butt et al, 2014) hinder the recovery of scolices because strobiles rupture. In addition, the recovery of the remaining scolices is difficult owing to the presence of mucus and mucosal fragments and may be damaged upon removal or may even be undetected.…”

Section: Resultsmentioning

confidence: 99%

“…Helminthoses evaluation in poultry is part of national and international regulations (Nurelhuda et al, 1989;Yazwinski et al, 1992;2003;Silva et al, 1999;Vich Topic GL21, 2001;Tucker et al, 2007;Alam et al, 2014;Butt et al, 2014). Methodologies owing to the cestodes recovery basically consist of collecting intestinal contents and materials scraped from the small intestine mucosa, followed by helminth screening.…”

Section: Introductionmentioning

confidence: 99%

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Mello and Campos (1974) method adapted for the recovery of cestodes in birds ( Gallus domesticus )

et al. 2016

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The specific diagnosis and evaluation of the intensity of avian helminth infections are essential for efficacy studies and the determination of drug doses targeted to their control. This study evaluated the Mello and Campos method, originally described for parasitological diagnosis in dogs, in the recovery of scolices from cestode parasites of poultry (Gallus domesticus ). A total of 52 naturally infected birds obtained from farms underwent parasitological necropsy using the Mello and Campos method. The method consisted of four steps: content, soaking, scraping and evaluation. The number of scolices recovered per bird ranged from 1 to 4,345, and the highest number of scolices was recovered from material derived from the soaking step. The cestodes species diagnosed were Amoebotaenia cuneata , Choanotaenia infundibulum , Hymenolepis sp., Raillietina tetragona , Raillietina echinobothrida and Raillietina cesticillus . The Mello and Campos method, originally used to test for helminths in dogs, was effective in avian cestode testing because it includes a soaking step, which enables a more efficient recovery of scolices.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mello and Campos (1974) method adapted for the recovery of cestodes in birds ( Gallus domesticus )

et al. 2016

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“…Nevertheless, it is important to point out that they have shown better efficacy than ivermectin administered alone [3][4][5] praziquantel [6,7] for fenbendazole used as a single treatment [8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Treatments Comparison of day 0 with each one of the average days of sampling (7,14,21, and 28) showed significant differences, using the Wilcoxon rank test (p < 0.005).…”

Section: Comparison Of Fecal Samplings Betweenmentioning

confidence: 98%

Comparison of the Anthelmintic Efficacy of Three Commercial Products against Ascarids and Capillaria SPP. in Fighting Cocks

Ibarra-Velarde¹,

Guerrero-Molina²,

Vera‐Montenegro³

et al. 2011

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“…However, some forums report that PZQ kills shrimp (Table 2). The drug does not appear to cause significant harm to mammals, birds, fish, amphibians and reptiles [47][48][49][50].…”

Section: There Is a Considerable "Grey Literature" On Pzqmentioning

confidence: 99%

The Mechanism of Action of Praziquantel: Six Hypotheses

Thomas

Timson

2018

CTMC

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Despite being one of the most commonly used drugs, the molecular mechanism of action of the anthelmintic praziquantel remains unknown. There are some unusual features of this drug. Critically, widespread resistance to praziquantel has not developed despite decades of use. Here, we set out some challenges in praziquantel research and propose some provocative hypotheses to address these. We suggest that praziquantel may have multiple pharmacologically relevant targets and the effects on these may synergise to produce an overall, detrimental effect on the parasite. Praziquantel also acts on a number of host proteins and we propose that these actions are important in the drug’s overall mechanism. Although the drug is largely used in the treatment of human and domestic animal worm infections, there is a considerable “grey literature” along with some academic studies which may have been overlooked. It appears that praziquantel may be effective against hydra. It may also be effective against some unicellular parasites such as Giardia spp. Further, scientific work on these understudied areas may be useful in understanding the molecular mechanism in Trematoda. The lack of widespread resistance suggests that praziquantel may act, at least in part, on a protein-protein interaction. Altered drug metabolism or enhanced drug efflux are the most likely ways resistance may arise. There is a critical need to understand the biochemical pharmacology of this drug in order to inform the discovery of the next generation of anthelmintic drugs.

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Anthelmintic activity of praziquantel onRaillietina tetragona in chickens

Cited by 6 publications

References 4 publications

Mello and Campos (1974) method adapted for the recovery of cestodes in birds ( Gallus domesticus )

Mello and Campos (1974) method adapted for the recovery of cestodes in birds ( Gallus domesticus )

Comparison of the Anthelmintic Efficacy of Three Commercial Products against Ascarids and Capillaria SPP. in Fighting Cocks

The Mechanism of Action of Praziquantel: Six Hypotheses

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