Anthelminthic properties of mangostin and mangostin diacetate

Keiser, Jennifer; Vargas, Mireille; Winter, R.

doi:10.1016/j.parint.2012.01.004

Cited by 22 publications

(8 citation statements)

References 20 publications

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“…Several pharmacologists or researchers want to clarify its properties. They found that G. mangostana pericarp had many properties such as antibacterial [13], antifungal [14], and anthelmintic activities [15]. In the present study, histopathological changes were observed in tissues of B. siamensis goniomphalos incubated in crude extract solutions of camellia seed and mangosteen pericarp, and to estimate the molluscicidal effects of the 2 plant substances.…”

Section: Introductionmentioning

confidence: 90%

Histopathological Changes in Tissues of Bithynia siamensis goniomphalos Incubated in Crude Extracts of Camellia Seed and Mangosteen Pericarp

et al. 2013

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The present study was performed to observe histopathological changes in tissues of Bithynia siamensis goniomphalos (Gastropoda, Bithyniidae) incubated in crude extract solutions of camellia (Camellia oleifera) seed and mangosteen (Garcinia mangostana) pericarp, and furthermore to estimate the molluscicidal effects of 2 plant substances. Substantial numbers of bithyniid snails were incubated in various concentrations of 2 plant solution for 24 hr. As the positive control, snails incubated in various concentrations of niclosamide, a chemical molluscicide, were used. The histopathological findings were observed in sectioned snail specimens of each experimental and control groups. The results showed that both camellia and mangosteen extracts had molluscicidal effects at 24 hr with 50% lethal concentration (LC50) at concentrations of 0.003 and 0.002 g/ml, respectively, while niclosamide had LC50 at concentrations 0.599 ppm. B. siamensis goniomphalos snail tissues (foot, gill, and digestive system) showed disruption of columnar muscle fibers of the foot, reduction of the length and number of gill cilia, numerous mucous vacuoles, and irregularly shaped of epithelial cells. Irregular apical and calciferous cells, dilatation of the digestive gland tubule, and large hemolymphatic spaces, and irregular apical surfaces, detachment of cilia, and enlargement of lysosomal vacuoles of epidermis were also shown in all groups. By the present study, it is confirmed that 2 plants, camellia and mangosteen, are keeping some substance having molluscicidal effects, and histopathological findings obtained in this study will provide some clues in further studies on their action mechanisms to use them as natural molluscicides.

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Section: Introductionmentioning

confidence: 90%

Histopathological Changes in Tissues of Bithynia siamensis goniomphalos Incubated in Crude Extracts of Camellia Seed and Mangosteen Pericarp

et al. 2013

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“…(Guttiferae) (GM), commonly called mangosteen, is a tropical plant known as the ''queen of fruit'' due to its pleasant taste and health benefits. The pericarp of mangosteen has been used for a long time in Ayurvedic medicine for the treatment of diarrhea, dysentery and abdominal pain (Balasubramanian & Rajagopalan 1988) and it has been reported to possess anti-inflammatory (Gopalakrishnan et al 1980;Nakatani et al 2002;Chen et al, 2008), antioxidant (Yoshikawa et al 1994;Moongkarndi et al 2004;Jung et al 2006), anticancer (Ho et al 2002;Matsumoto et al 2003), antimalarial (Riscoe et al 2005;Mahabusarakam et al 2006), antiparasite (Keiser et al 2012), antifungal (Sundaram et al 1983;Gopalakrishnan et al 1997) and antibacterial activities (Iinuma et al 1996;Suksamrarn et al 2003;Chomnawang et al 2005;Rassameemasmaung et al 2007). The pericarp of G. mangostana is a rich source of bioactive xanthones, namely a-, cand b-mangostin, garcinone E and gartanin (Gutierrez-Orozco & Failla 2013).…”

Section: Introductionmentioning

confidence: 99%

In vivoantibacterial activity ofGarcinia mangostanapericarp extract against methicillin-resistantStaphylococcus aureusin a mouse superficial skin infection model

Tatiya-aphiradee

Chatuphonprasert

Jarukamjorn

2016

Pharmaceutical Biology

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“…[10][11][12][13][14][15][16] Therefore, the correlation between the anthelmintic activity of compounds against laboratory and field isolates of human hookworms remains largely unknown.…”

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confidence: 99%

“…[6][7][8][9] However, novel compounds identified using small animal models of hookworm infection are rarely screened for comparable activity against field isolates of human hookworms. [10][11][12][13][14][15][16] Therefore, the correlation between the anthelmintic activity of compounds against laboratory and field isolates of human hookworms remains largely unknown.…”

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confidence: 99%

In vitro Screening of Compounds against Laboratory and Field Isolates of Human Hookworm Reveals Quantitative Differences in Anthelmintic Susceptibility

Treger

Otchere

Keil

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. A panel of 80 compounds was screened for anthelmintic activity against a laboratory strain of Ancylostoma ceylanicum and field isolates of hookworm obtained from school children in the Kintampo North District of the Brong Ahafo Region of Ghana. Although the laboratory strain of A. ceylanicum was more susceptible to the compounds tested than the field isolates of hookworm, a twofold increase in compound concentration resulted in comparable egg hatch percent inhibition for select compounds. These data provide evidence that the efficacy of anthelmintic compounds may be species-dependent and that field and laboratory strains of hookworm differ in their sensitivities to the anthelmintics tested. These data also suggest that both compound concentration and hookworm species must be considered when screening to identify novel anthelmintic compounds.Human hookworm disease results from infection by two genera of hookworms, Ancylostoma spp. and Necator americanus. Albendazole (ABZ) and mebendazole (MBZ) are the primary drugs used to treat hookworm infection. A recent meta-analysis and review of field-based studies have shown that single-dose treatment cure rates with ABZ and MBZ are low (72% and 15%, respectively).1,2 Compounding these treatment failure rates in humans is the well-documented emergence of drug resistance to ABZ and MBZ among parasitic nematodes of agricultural and veterinary importance. [3][4][5] In light of this information, the development of novel anthelmintic chemotherapeutics is necessary.Currently, the identification and development of novel anthelmintic compounds to cure hookworm infection rely on laboratory-based screening for inhibitors of egg hatching, larval motility and morphology, and/or adult worm survival.6-9 However, novel compounds identified using small animal models of hookworm infection are rarely screened for comparable activity against field isolates of human hookworms. [10][11][12][13][14][15][16] Therefore, the correlation between the anthelmintic activity of compounds against laboratory and field isolates of human hookworms remains largely unknown.Moreover, for those cases in which anthelmintic activity is investigated, the larvicidal, rather than ovicidal, properties of a compound are usually analyzed. [17][18][19][20] Ovicidal activity is more frequently and most readily assayed in resource-limited field settings, where larval and adult hookworm-based assays are impractical tools for assessing anthelmintic activity. [21][22][23]

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Anthelminthic properties of mangostin and mangostin diacetate

Cited by 22 publications

References 20 publications

Histopathological Changes in Tissues of Bithynia siamensis goniomphalos Incubated in Crude Extracts of Camellia Seed and Mangosteen Pericarp

Histopathological Changes in Tissues of Bithynia siamensis goniomphalos Incubated in Crude Extracts of Camellia Seed and Mangosteen Pericarp

In vivoantibacterial activity ofGarcinia mangostanapericarp extract against methicillin-resistantStaphylococcus aureusin a mouse superficial skin infection model

In vitro Screening of Compounds against Laboratory and Field Isolates of Human Hookworm Reveals Quantitative Differences in Anthelmintic Susceptibility

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