Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin

Abstract

This study investigated the antiallergic and anthelmintic properties of Vimang (an aqueous extract of Mangifera indica family stem bark) and mangiferin (the major polyphenol present in Vimang) administered orally to mice experimentally infected with the nematode, Trichinella spiralis. Treatment with Vimang or mangiferin (500 or 50 mg per kg body weight per day, respectively) throughout the parasite life cycle led to a significant decline in the number of parasite larvae encysted in the musculature; however, neither treatment was effective against adults in the gut. Treatment with Vimang or mangiferin likewise led to a significant decline in serum levels of specific anti-Trichinella IgE, throughout the parasite life cycle. Finally, oral treatment of rats with Vimang or mangiferin, daily for 50 days, inhibited mast cell degranulation as evaluated by the passive cutaneous anaphylaxis test (sensitization with infected mouse serum with a high IgE titre, then stimulation with the cytosolic fraction of T. spiralis muscle larvae). Since IgE plays a key role in the pathogenesis of allergic diseases, these results suggest that Vimang and mangiferin may be useful in the treatment of diseases of this type.

A review of the bioactivity of south African herbal teas: rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia)

“…Thus, while mangiferin does not affect the primary antibody response (principally IgM), it may stimulate the production of interleukins by helper T cells that in turn stimulate the conversion of Th-1 to Th-2 cells. Garcia et al (2003b) also found that oral treatment with mangiferin at 50 mg/kg/day significantly reduced the number of Trichinella spiralis larvae encysted in the musculature of experimentally infected mice when administered either on the day of infection and throughout the parasite life cycle (~35 days) or for 20 days pre-infection to 11 days post-infection compared with untreated control mice. Mangiferin also reduced the levels of specific anti-Trichinella IgE in the serum of mice measured at 28 days and 35 days post-infection.…”

Antidiarrheal Activity ofLithocarpus dealbata. andUrena lobata. Extracts: Therapeutic Implications

“…The role of quercetin as a promising antidiarrheal molecule has also been verified by several other workers, Galvez (1993b), Galvez et al (1995), and Perrucci et al (2006), to name a few. Similarly, several studies in the past have revealed mangiferin acts against antiinflammatory response by inhibiting the production and release of inflammatory molecules, such as prostaglandins, mast cells, and histamine (Garcia et al, 2003;Rivera et al, 2006). These anti-inflammatory molecules have the ability to relax smooth muscles and thereby relieve the gastrointestinal tract (Katzung, 2004).…”

Antiviral potential of mangiferin against poliovirus

“…Multiple pharmacological activities have been scientifically demonstrated, such as, antitumor [14][15][16], immunomodulatory [17], antidiabetic [18], antioxidant [19;20], antiallergic [21], anthelminthic [22], antiinflammatory and antinociceptive [23;24] [31] and Gold-Smith et al [32] mangiferin exhibits minimal toxicity in vitro and in vivo. Although mangiferin is widely obtained from M. indica it was also described in several other plant species in the African and Asian continents [33].…”