Anterior segment Scheimpflug imaging for detecting primary angle closure disease

Winegarner, Andrew; Miki, Atsuya; Kumoi, Miho; Ishida, Yusuke; Wakabayashi, Taku; Sakimoto, Susumu; Usui, Shinichi; Matsushita, Kazunobu; Nishida, Kohji

doi:10.1007/s00417-018-4171-x

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…[6][7][8] Hence, early screening and detection of PACD, especially at the PACS and early PAC stages would be valuable for control of the disease and prevention of visual impairment caused by PACG. 9 The current gold standard for angle-closure assessment is gonioscopy; this is a contact-based, subjective, and examiner-dependent technique with moderate reproducibility. 10,11 Accordingly, gonioscopy is not an optimal tool for large-scale population-based screening.…”

Section: Introductionmentioning

confidence: 99%

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Establishment and Comparison of Algorithms for Detection of Primary Angle Closure Suspect Based on Static and Dynamic Anterior Segment Parameters

Zhang

et al. 2020

Trans. Vis. Sci. Tech.

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Section: Introductionmentioning

confidence: 99%

“…6 – 8 Hence, early screening and detection of PACD, especially at the PACS and early PAC stages would be valuable for control of the disease and prevention of visual impairment caused by PACG. 9 …”

Section: Introductionmentioning

confidence: 99%

Establishment and Comparison of Algorithms for Detection of Primary Angle Closure Suspect Based on Static and Dynamic Anterior Segment Parameters

Zhang

et al. 2020

Trans. Vis. Sci. Tech.

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“…Согласно Winegarner A. еt al. (2019), проводивших визуализацию переднего отрезка глаза по Scheimpfl ug, самым чувствительным параметром в скрининге закрытого угла передней камеры является глубина передней камеры [25].…”

Section:  роль биометрических параметров глазаunclassified

Эпидемиология, Классификация И Генетика Закрытоугольной Глаукомы

Bakunina¹,

Сотникова²,

Куроедов³

et al. 2021

Офтальмология. Восточная Европа

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Первичная закрытоугольная глаукома (ПЗУГ) является одной из наиболее неблагоприятных форм глаукомы с точки зрения нарушения зрительных функций. До настоящего времени нет единства в классификации ПЗУГ, и мало исследований по генетике заболевания. В статье представлен обзор литературы с описанием современных данных об эпидемиологии, классификации и генетике закрытоугольной глаукомы. Факторами риска ПЗУГ являются: пожилой возраст, женский пол, азиатская раса. К анатомическим факторам риска закрытия угла передней камеры глаза относятся маленькая ширина, площадь и объем передней камеры, толстая радужка с большой кривизной и большая кривизна хрусталика. Первичное закрытие угла передней камеры проходит 3 стадии: подозрение на первичное закрытие угла, первичное закрытие угла и первичная закрытоугольная глаукома. Если наблюдается иридотрабекулярный контакт на всем протяжении с резким повышением внутриглазного давления, то ставится диагноз острого приступа глаукомы. Острый приступ глаукомы может развиваться по механизму зрачкового блока, при конфигурации плоской радужки, при синдроме неправильного тока внутриглазной жидкости или по смешанному типу. Снижение плотности коллагена I типа в ткани радужной оболочки связано с уменьшением площади радужки и увеличением ширины передней камеры, что может способствовать прогрессированию заболевания. Радужная оболочка глаз пациентов с ПЗУГ в анамнезе значительно более жесткая по сравнению со здоровыми. Несмотря на то что строго наследуемые мутации, характерные для ПЗУГ, до сих пор не идентифицированы, ПЗУГ можно назвать мультифакториальным, генетически детерминированным заболеванием, которое является результатом взаимодействия генетических и эпигенетических факторов. Учет генетических полиморфизмов и других биомаркеров значительно повысит эффективность диагностики и лечения заболевания. Primary angle-closure glaucoma is one of the most prognostically unfavorable forms of glaucoma in terms of visual impairment. Recently, there has been a lot of information in the literature concerning the diagnosis of angle- closure glaucoma, however, algorithms for detecting angle-closure glaucoma at an early stage of the disease have not yet been developed. Despite modern diagnostic capabilities, the issues of detecting glaucoma of "short" eyes, the search for new and the determination of already known genetic markers of predisposition to angle-closure glaucoma and acute attack of glaucoma remain quite relevant. There is also no consensus on the classification of angle-closure glaucoma.

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“…Scheimpflug imaging (available on commercial clinical devices such as the Pentacam and the Orbscan) is an imaging modality that has been applied to the assessment and screening of patients with angle closure disease 3–5 . An advantage afforded by Scheimpflug imaging is the quantitative information provided at various locations across the width of the anterior chamber 6 …”

Section: Introductionmentioning

confidence: 99%

Intra‐session repeatability of anterior chamber depth across the chamber width using Pentacam Scheimpflug imaging in healthy subjects

Phu

Tong

Kalloniatis

2021

Ophthalmic Physiologic Optic

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Purpose Despite the importance of anterior chamber depth (ACD) measurements in disease and ageing, the repeatability and their threshold for change is not known. Our purpose was to determine the intra‐session repeatability of Pentacam Scheimpflug photography for measuring the ACD across the chamber width in healthy subjects and thus inform expected limits of normality. Methods Pentacam Scheimpflug photography was used to obtain ACD measurements at 57 points across the central 8mm of the chamber width from one randomly selected eye of 130 healthy (normal vision and no ocular diseases, except age‐normal cataracts) subjects (median age 58.0 years, interquartile range 46.3–63.0 years; 48 males, 82 females). Intra‐session ACD measurements were compared. Univariate and multivariate linear regression was performed to identify categorical and continuous variables demonstrating a significant relationship with ACD and its repeatability. Results Bland‐Altman analyses showed no directional or depth‐dependent bias in the difference between the first and second tests (mean bias −0.003 mm, 95% limits of agreement −0.115 to +0.109 mm). Multivariate analysis found gender to be a significant factor (p < 0.0001), but not age (p = 0.69) nor ethnicity (p = 0.65), although the model fit was poor (R2 = 0.004). There were no regional differences in repeatability measures found in males, but six locations in the superior aspect in females were found to be significantly different in their repeatability characteristics. Tolerance limits used to calculate the number of step sizes between <20 and >60‐year‐old age groups found 8.1–11.5 steps for females, and 7.5–9.2 steps for males. Conclusions Scheimpflug imaging using the Pentacam has excellent intra‐session repeatability. Only gender appeared to affect repeatability characteristics, manifesting with a greater number of meaningful steps of change between two extremes of age range in females compared to males, which provides guidance for identifying clinically significant and measurable change between tests.

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Anterior segment Scheimpflug imaging for detecting primary angle closure disease

Cited by 14 publications

References 31 publications

Establishment and Comparison of Algorithms for Detection of Primary Angle Closure Suspect Based on Static and Dynamic Anterior Segment Parameters

Establishment and Comparison of Algorithms for Detection of Primary Angle Closure Suspect Based on Static and Dynamic Anterior Segment Parameters

Эпидемиология, Классификация И Генетика Закрытоугольной Глаукомы

Intra‐session repeatability of anterior chamber depth across the chamber width using Pentacam Scheimpflug imaging in healthy subjects

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