Anterior Cruciate Ligament Rupture and Osteoarthritis Progression

Wong, J.; Khan, Tanvir; Jayadev, Chethan; Khan, Wasim; Johnstone, David

doi:10.2174/1874325001206010295

Cited by 32 publications

(23 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A well-established risk factor for OA is joint injury, the archetypal example being anterior cruciate ligament rupture of the knee, which substantially increases risk of knee osteoarthritis in the years following injury [89]. In the hip, a common form of joint injury is an acetabular labral tear, which warrants further study as a possible contributing factor to the development of hip OA.…”

Section: Etiology and Risk Factors For Hip Oamentioning

confidence: 99%

Hip Osteoarthritis: Etiopathogenesis and Implications for Management

2016

View full text Add to dashboard Cite

Highly prevalent among the elderly, hip osteoarthritis (OA) carries a heavy burden of disease. Guidelines for the management of hip OA are often extrapolated from knee OA research, despite clear differences in the etiopathogenesis and response to treatments of OA at these sites. We propose that hip OA requires specific attention separate from other OA phenotypes. Our understanding of the etiopathogenesis of hip OA has seen significant advance over the last 15 years, since Ganz and colleagues proposed femoroacetabular impingement (FAI) as an important etiological factor. This narrative review summarizes the current understanding of the etiopathogenesis of hip OA and identifies areas requiring further research. Therapeutic approaches for hip OA are considered in light of the condition’s etiopathogenesis. The evidence for currently adopted management strategies is considered, especially those approaches that may have disease-modifying potential. We propose that shifting the focus of hip OA research and public health intervention to primary prevention and early detection may greatly improve the current management paradigm.

show abstract

Section: Etiology and Risk Factors For Hip Oamentioning

confidence: 99%

Hip Osteoarthritis: Etiopathogenesis and Implications for Management

2016

View full text Add to dashboard Cite

show abstract

“…Acute anterior cruciate ligament (ACL) injury is a high-risk factor for the development of post-traumatic osteoarthritis 1-3 . Previous studies have shown that even with ACL reconstruction surgery, 50 to 70 percent of ACL-injured patients have radiological signs of osteoarthritis (OA) within 10-15 years post-injury 4, 5 .…”

Section: Introductionmentioning

confidence: 99%

MR T1ρ and T2 of meniscus after acute anterior cruciate ligament injuries

Wang

Pedoia

et al. 2016

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Objective To evaluate differences in meniscal T1ρ and T2 quantification in patients with acute anterior cruciate ligament (ACL) injuries and to determine correlations of these differences with MR morphological grading and patient-reported outcomes. Design Bilateral knees of 52 patients with acute ACL injury and 20 healthy controls were scanned using 3T MRI T1ρ and T2 mapping in this prospective study. Quantitative analysis of the meniscus was performed in anterior and posterior horns of the lateral and medial menisci. Morphological meniscal damage was assessed using modified whole-organ MRI scores (WORMS). Measurements were compared between injured, uninjured contralateral, and control knees using a mixed-effects regression model. Correlations between meniscal T1ρ/T2, WORMS and Knee Injury and Osteoarthritis Outcome Scores (KOOS) were examined using partial correlation analysis. Results Mean meniscal T1ρ and T2 values were significantly higher in ACL-injured knees compared to control and contralateral knees. Menisci of ACL-injured knees without tears, including those limited to modified meniscal WORMS grade 0, also had significantly higher T1ρ and T2 values compared to menisci of uninjured knees. Within ACL-injured knees, T1ρ and T2 values showed significant positive associations with meniscal WORMS and significant negative associations with KOOS. Conclusion Acute ACL injuries are associated with significantly increased meniscal T1ρ and T2 values in both patients with and without meniscal lesions or tears, suggesting quantitative MRI provides more sensitive measures of meniscal differences compared to traditional morphological MRI sequences. Correlation between meniscal T1ρ/T2 and KOOS suggest that quantitative MRI is reflective of the extent of patients’ clinical symptoms.

show abstract

“…This finding seems to be directly connected to the higher rate of dynamic instability, testified by the higher values observed with the pivot shift test in these patients. Statistical evaluation of the results highlighted the correlation between dynamic instability and arthritis progression, as previously described by Wong et al 42 and Ayeni et al 43 It is not clear why more instability was noted in the 1SHG group vs the 2SHG group, but it may be related to lower mechanical graft strength or less crosssectional area of the graft within the intercondylar notch, both of which are inherent to single-strand reconstruction.…”

Section: Andmentioning

confidence: 63%

Over-the-Top Anterior Cruciate Ligament Reconstruction Using Single- or Double-Strand Hamstrings Autograft

Ruffilli¹,

Buda²,

Pagliazzi³

et al. 2015

Orthopedics

View full text Add to dashboard Cite

The purpose of this study is to (1) report the long-term clinical and radiographic outcomes of a nonanatomical anterior cruciate ligament (ACL) reconstruction using an over-the-top (OTT) femoral route and (2) compare single-strand (1SHG) and double-strand (2SHG) hamstrings graft reconstruction. Fifty-one consecutive patients (mean age, 29.2±3.8 years) underwent nonanatomical ACL reconstruction using OTT femoral passage. Twenty patients underwent 1SHG reconstruction and 31 underwent 2SHG reconstruction. International Knee Documentation Committee (IKDC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Tegner score, and KT-1000 (Medmetric Corporation, San Diego, California) evaluation were recorded at a mean follow-up of 12.1±1.6 years. At final follow-up, radiographic evaluation was performed according to the IKDC grading system. Mean IKDC subjective score at follow-up was 76.6±21.9 in the 1SHG group and 88.9±10.0 in the 2SHG (P=.009). Average KOOS was 82.6±18.7 in the 1SHG group and 92.4±9.2 in the 2SHG group (P=.016). Objective IKDC evaluation showed a higher percentage of normal knees in the 2SHG group (P=.018). Pivot shift testing revealed a significantly higher number of normal knees in the 2SHG group (P=.001). Radiographs showed fewer degenerative changes in the 2SHG group at final follow-up in the medial (P=.01) and lateral (P=.037) compartments. Nonanatomical ACL reconstruction using the OTT technique provided satisfactory results in terms of control of both static and dynamic instability at long-term follow-up, thus preventing degenerative joint disease. The 2SHG group showed better subjective and functional outcomes with fewer degenerative changes compared with the 1SHG group at long-term follow-up.

show abstract

Anterior Cruciate Ligament Rupture and Osteoarthritis Progression

Cited by 32 publications

References 50 publications

Hip Osteoarthritis: Etiopathogenesis and Implications for Management

Hip Osteoarthritis: Etiopathogenesis and Implications for Management

MR T1ρ and T2 of meniscus after acute anterior cruciate ligament injuries

Over-the-Top Anterior Cruciate Ligament Reconstruction Using Single- or Double-Strand Hamstrings Autograft

Contact Info

Product

Resources

About