Anterior cingulate volume in pediatric bipolar disorder and autism

Neuroanatomical correlates of genetic risk for bipolar disorder: A voxel-based morphometry study in bipolar type I patients and healthy first degree relatives

“…Another VBM study reported greater GM density in the ACC of bipolar patients than in controls and lithium-treated patients showed significantly greater GM density in the right ACC than patients not-taking lithium (Bearden et al, 2007). Decreased (Atmaca et al, 2007;Chiu et al, 2008;Kaur et al, 2005;Lochhead et al, 2004;Lyoo et al, 2004) or unchanged (Biederman et al, 2008;Brambilla et al, 2002;Zimmerman et al, 2006) GM density/volume in the ACC of bipolar patients have also been reported. Although an association between GM deficits in the right ACC and the genetic risk for bipolar disorder has been reported in one high-risk design MRI study using a quantitative measure of genetic liability and computational morphometric techniques (McDonald et al, 2004), we did not replicate this finding in our sample using VBM.…”

Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

“…Specifically, a GM volume deficit in the left perigenual ACC has been reported in both medicated and unmedicated children and/or adolescents with BD (Chiu et al, 2008;Kaur et al, 2005;Singh et al, 2012;Wilke et al, 2004). The fact that in some cases these morphometric abnormalities were observed in pediatric cases with a single recent episode of mania raises the possibility that the reduction in GM volume of the perigenual ACC predates illness onset or occurs very early in the course of the disorder.…”

Retraction: Altered affective, executive and sensorimotor resting state networks in patients with pediatric mania

“…Abnormal structural findings in children with bipolar disorder include decreased volume in the anterior cingulate cortex (ACC), 10 dorsolateral prefrontal cortex (DLPFC) and amygdala, 11 and increased volume in the basal ganglia. 12 Altered white matter integrity with lower fractional anisotropy has also been reported in the limbic system, anterior and poster ior corona radiata and the corpus callosum.…”