Retraction: Altered affective, executive and sensorimotor resting state networks in patients with pediatric mania

Wu, Minxian; Lu, Lisa H.; Passarotti, Alessandra M.; Wegbreit, Ezra; Fitzgerald, Jacklynn M.; Pavuluri, Mani N.

doi:10.1503/jpn.120073

Cited by 17 publications

(12 citation statements)

References 56 publications

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“…Abnormally increased amygdala activity may be more evident in youth than in adults with bipolar disorder(139). Studies in bipolar disorder youth also demonstrated abnormally decreased amygdala volumes(69,142,143); decreased orbitofrontal cortex and anterior cingulate cortex gray matter(142); abnormally reduced fractional anisotropy in white matter tracts connecting prefrontal and subcortical regions(144-147); and also in at-risk youth(148); and altered resting state in prefrontal cortical circuitry(149), and largescale networks(150). Longitudinal studies are clearly needed to examine developmental trajectories of structural and functional changes in prefrontal cortical-subcortical circuitry in individuals with bipolar disorder, and those youth at risk of future mood and psychotic disorders.…”

Section: Introductionmentioning

confidence: 99%

A Critical Appraisal of Neuroimaging Studies of Bipolar Disorder: Toward a New Conceptualization of Underlying Neural Circuitry and a Road Map for Future Research

Phillips¹,

Swartz²

2014

AJP

513

415

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Objective This critical review appraises neuroimaging findings in bipolar disorder in emotion processing, emotion regulation, and reward processing neural circuitry, to synthesize current knowledge of the neural underpinnings of bipolar disorder, and provide a neuroimaging research “roadmap” for future studies. Method We examined findings from all major studies in bipolar disorder that used fMRI, volumetric analyses, diffusion imaging, and resting state techniques, to inform current conceptual models of larger-scale neural circuitry abnormalities in bipolar disorder Results Bipolar disorder can be conceptualized in neural circuitry terms as parallel dysfunction in bilateral prefrontal cortical (especially ventrolateral prefrontal cortical)-hippocampal-amygdala emotion processing and emotion regulation neural circuitries, together with an “overactive” left-sided ventral striatal-ventrolateral and orbitofrontal cortical reward processing circuitry, that result in characteristic behavioral abnormalities associated with bipolar disorder: emotional lability, emotional dysregulation and heightened reward sensitivity. A potential structural basis for these functional abnormalities are gray matter decreases in prefrontal and temporal cortices, amygdala and hippocampus, and fractional anisotropy decreases in white matter tracts connecting prefrontal and subcortical regions. Conclusion Neuroimaging studies of bipolar disorder clearly demonstrate abnormalities in neural circuitries supporting emotion processing, emotion regulation and reward processing, although there are several limitations to these studies. Future neuroimaging research in bipolar disorder should include studies adopting dimensional approaches; larger studies examining neurodevelopmental trajectories in bipolar disorder and at-risk youth; multimodal neuroimaging studies using integrated systems approaches; and studies using pattern recognition approaches to provide clinically useful, individual-level data. Such studies will help identify clinically-relevant biomarkers to guide diagnosis and treatment decision-making for individuals with bipolar disorder.

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Section: Introductionmentioning

confidence: 99%

A Critical Appraisal of Neuroimaging Studies of Bipolar Disorder: Toward a New Conceptualization of Underlying Neural Circuitry and a Road Map for Future Research

Phillips¹,

Swartz²

2014

AJP

513

415

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“…Two studies used a region of interest (ROI) analysis approach: one reported increased connectivity between the left DLPFC and superior temporal cortex in youth with BD relative to healthy youth, 19 and the other reported decreased amygdala-posterior insula connectivity in BD youth 20 . Using a model-free independent components analysis (ICA) approach, Wu et al 21 found that youth with BD exhibited altered affective, executive, and sensorimotor networks, and that greater connectivity of the right amygdala within the affective network was associated with better executive function in children with BD, but not in controls. Collectively, the results of these studies suggest that pediatric BD is characterized by aberrant patterns of prefrontal and limbic connectivity.…”

Section: Introductionmentioning

confidence: 99%

“…Drawing on fMRI findings in the amygdala obtained during rest in adults and youth with BD, 17,18,20,21 we predicted that, compared with healthy youth, youth with BP-I would exhibit disrupted functional connectivity at rest between amygdala subregions and key brain regions associated with emotion expression and emotion regulation, including the VLPFC, ACC, and insula. We also predicted that these aberrant patterns of connectivity in amygdala subregions would be associated with core symptom dimensions of BD.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder

Singh

Kelley

Chang

et al. 2015

Journal of the American Academy of Child & Adolescent Psych

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Objective Bipolar disorder (BD) commonly begins during adolescence and may continue into adulthood. Studies in adults with BD suggest that disruptions in amygdalar neural circuitry explain the pathophysiology underlying the disorder. Importantly, however, amygdala subregion networks have not yet been examined in youth close to mania onset. The goal of this study was to compare resting state functional connectivity patterns in amygdala subregions in youth with bipolar-I (BP-1) disorder with patterns in healthy controls. Method Centromedial, laterobasal, and superficial amygdala subdivisions were assessed during rest and examined in relation to clinical measures of mania in youth (14 to 20 years old) with BP-I who experienced only a single episode of mania (n=20, “BD”) and age-matched healthy comparison youth without any personal or family history of DSM-IV Axis I disorders (n=23, “HC”). Results Relative to HC youth, youth with BD exhibited decreased connectivity between the laterobasal subdivision of the amygdala and the hippocampus and precentral gyrus, and increased connectivity between the laterobasal subdivision and the precuneus. Connectivity between the right laterobasal amygdala and right hippocampus was positively correlated with levels of anxiety in BD but not in HC youth, and connectivity between the right laterobasal amygdala and right precuneus was negatively correlated with insight about bipolar illness. Conclusion Youth with BD have abnormal amygdala resting state network connections to regions that are critical for emotional processing and self-awareness. Longitudinal studies are needed to determine whether these aberrant patterns in youth with BD can be altered with intervention and influence the course of disorder.

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“…These findings have been corroborated in a sample of 36 children (ages 7-11), 17 of which had a history of MDD [42]. However, other studies found greater RSFC between sgACC and frontal regions in unmedicated adolescents with MDD (n=23) compared to controls (n=36) [43] and in adolescents/young adults with MDD (n=18) compared to controls (n=20) [44]. Furthermore, while Gaffrey and colleagues found greater RSFC between the sgACC and precuneus among their children with histories of MDD [42], Connolly et al found lower RSFC between sgACC and precuneus in their adolescent MDD group [43].…”

Section: Resting State Functional Connectivity Studies With Clinical mentioning

confidence: 74%

“…However, other studies found greater RSFC between sgACC and frontal regions in unmedicated adolescents with MDD (n=23) compared to controls (n=36) [43] and in adolescents/young adults with MDD (n=18) compared to controls (n=20) [44]. Furthermore, while Gaffrey and colleagues found greater RSFC between the sgACC and precuneus among their children with histories of MDD [42], Connolly et al found lower RSFC between sgACC and precuneus in their adolescent MDD group [43]. Divergence of findings in the pattern of sgACC RSFC abnormalities across studies may stem from differences in methodological steps, sample characteristics (e.g.…”

Section: Resting State Functional Connectivity Studies With Clinical mentioning

confidence: 94%

Developmental Resting State Functional Connectivity for Clinicians

Hulvershorn

Cullen

Francis

et al. 2014

Curr Behav Neurosci Rep

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Resting state functional magnetic imaging (fMRI) is a novel means to examine functional brain networks. It allows investigators to identify functional networks defined by distinct, spontaneous signal fluctuations. Resting state functional connectivity (RSFC) studies examining child and adolescent psychiatric disorders are being published with increasing frequency, despite concerns about the impact of motion on findings. Here we review important RSFC findings on typical brain development and recent publications of child and adolescent psychiatric disorders. We close with a summary of the major findings and current strengths and limitations of RSFC studies.

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Retraction: Altered affective, executive and sensorimotor resting state networks in patients with pediatric mania

Abstract: Brain blood flow and local synchrony abnormalities in medication-free patients with MDD

Cited by 17 publications

References 56 publications

A Critical Appraisal of Neuroimaging Studies of Bipolar Disorder: Toward a New Conceptualization of Underlying Neural Circuitry and a Road Map for Future Research

A Critical Appraisal of Neuroimaging Studies of Bipolar Disorder: Toward a New Conceptualization of Underlying Neural Circuitry and a Road Map for Future Research

Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder

Developmental Resting State Functional Connectivity for Clinicians

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