Anterior cingulate error‐related activity is modulated by predicted reward

Amiez, Céline; Joseph, Jean-Paul; Procyk, Emmanuel

doi:10.1111/j.1460-9568.2005.04170.x

Cited by 203 publications

(195 citation statements)

References 26 publications

(43 reference statements)

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“…It is now clear that ACC S does not simply represent the occurrence of an error but is instead important whenever an outcome suggests the need to revise the estimate of the value of an action (Walton et al, 2004;Amiez et al, 2005Amiez et al, , 2006Kennerley et al, 2006;Matsumoto et al, 2007;Quilodran et al, 2008). Our results suggest that OFC can be similarly important in the learning of new stimulus-reinforcement associations and not simply in effecting a reversal in behavior after an error as has been previously highlighted (Fellows and Farah, 2003;Izquierdo et al, 2004).…”

Section: Discussionsupporting

confidence: 58%

“…By making it harder for subjects to determine which option is the most valuable, it may be possible to gain insights into prefrontal function not seen in deterministic settings. Recent evidence suggests ACC S is active and critical whenever reinforcement, whether positive or negative, provides information that allows a revision of the value of a choice (Matsumoto et al, 2003;Walton et al, 2004;Amiez et al, 2005Amiez et al, , 2006Kennerley et al, 2006), and it is possible that OFC performs a similar function. Experiment 4, therefore, examined whether OFC lesions impaired stimulus-reward learning in conditions in which each stimulus was allocated reward stochastically in a threechoice stimulus discrimination task ( Fig.…”

Section: Introductionmentioning

confidence: 99%

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Frontal Cortex Subregions Play Distinct Roles in Choices between Actions and Stimuli

Rudebeck

Behrens²,

Kennerley³

et al. 2008

J. Neurosci.

312

284

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The orbitofrontal cortex (OFC) has been implicated in reinforcement-guided decision making, error monitoring, and the reversal of behavior in response to changing circumstances. The anterior cingulate cortex sulcus (ACC S ), however, has also been implicated in similar aspects of behavior. Dissociating the unique functions of these areas would improve our understanding of the decision-making process. The effect of selective OFC lesions on how monkeys used the history of reinforcement to guide choices of either particular actions or particular stimuli was studied and compared with the effects of ACC S lesions. Both lesions disrupted decision making, but their effects were differentially modulated by the dependence on action-or stimulus-value contingencies. OFC lesions caused a deficit in stimulus but not action selection, whereas ACC S lesions had the opposite effect, disrupting action but not stimulus selection. Furthermore, OFC lesions that have previously been found to impair decision making when deterministic stimulus-reward contingencies are switched were found to cause a more general learning impairment in more naturalistic situations in which reward was stochastic. Both OFC and ACC S are essential for reinforcement-guided decision making rather than just error monitoring or behavioral reversal. The OFC and ACC S are both, however, more concerned with learning and making decisions, but their roles in selecting between stimulus and action values are distinct.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Frontal Cortex Subregions Play Distinct Roles in Choices between Actions and Stimuli

Rudebeck

Behrens²,

Kennerley³

et al. 2008

J. Neurosci.

312

284

View full text Add to dashboard Cite

show abstract

“…Later, local recordings in the banks of anterior cingulate sulcus revealed increased activity after errors, reduced rewards, and the absence of expected rewards (Ito et al, 2003;Amiez et al, 2005;Emeric et al, 2008;Quilodran et al, 2008). Although errorrelated activity has been reported in other areas (e.g., supplementary eye field, lateral prefrontal cortex, and orbitofrontal cortex), the incidence of outcome-related activity is particularly high in the ACC.…”

Section: Introductionmentioning

confidence: 99%

Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol

Vezoli

Procyk²

2009

J. Neurosci.

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Feedback monitoring and adaptation of performance involve a medial reward system including medial frontal cortical areas, the medial striatum, and the dopaminergic system. A considerable amount of data has been obtained on frontal surface feedback-related potentials (FRPs) in humans and on the correlate of outcome monitoring with single unit activity in monkeys. However, work is needed to bridge knowledge obtained in the two species. The present work describes FRPs in monkeys, using chronic recordings, during a trial and error task. We show that frontal FRPs are differentially sensitive to successes and failures and can be observed over long-term periods. In addition, using the dopamine antagonist haloperidol we observe a selective effect on FRP amplitude that is absent for pure sensoryrelated potentials. These results describe frontal dopaminergic-dependent FRPs in monkeys and corroborate a human-monkey homology for performance monitoring signals.

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“…Second, during stimulus processing and delay epochs in working memory paradigms, subsets of neurons encode the expected reward outcome associated with the stimulus (9). Third, following the behavioral response to a target stimulus, neuronal groups in ACC signal whether the behavioral response was incorrect or resulted in unexpected reward outcome (10)(11)(12)(13). Consequently, ACC neurons signal the adjustment of behavior following changes in task demands or unexpected outcomes on previous trials (8,14,15).…”

mentioning

confidence: 99%

Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors

Womelsdorf

Johnston

Vinck

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

211

153

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Accomplishing even simple tasks depend on neuronal circuits to configure how incoming sensory stimuli map onto responses. Controlling these stimulus-response (SR) mapping rules relies on a cognitive control network comprising the anterior cingulate cortex (ACC). Single neurons within the ACC convey information about currently relevant SR mapping rules and signal unexpected action outcomes, which can be used to optimize behavioral choices. However, its functional significance and the mechanistic means of interaction with other nodes of the cognitive control network remain elusive and poorly understood. Here, we report that core aspects of cognitive control are encoded by rhythmic theta-band activity within neuronal circuits in the ACC. Throughout task performance, theta-activity predicted which of two SR mapping rules will be established before processing visual target information. Task-selective theta-activity emerged particularly early during those trials, which required the adjustment of SR rules following an erroneous rule representation in the preceding trial. These findings demonstrate a functional correlation of cognitive control processes and oscillatory theta-band activity in macaque ACC. Moreover, we report that spike output of a subset of cells in ACC is synchronized to predictive theta-activity, suggesting that the theta-cycle could serve as a temporal reference for coordinating local task selective computations across a larger network of frontal areas and the hippocampus to optimize and adjust the processing routes of sensory and motor circuits to achieve efficient sensory-motor control.cognitive control | theta-synchronization | attention | oscillation | antisaccade C ognitive control refers to those neuronal processes responsible for assembling task-relevant information, which in turn biases sensory and motor pathways for efficient communication during task processing. Two core functions of cognitive control are (i) the implementation and maintenance of task-relevant stimulusresponse (SR) mapping rules, and (ii) the adjustment and optimization of such representations during task performance according to behavioral outcome. Both functions are subserved by a mosaic of interconnected neuronal groups distributed within frontal cortex (1-4). The anterior cingulate cortex (ACC) is one of the key nodes within this cognitive control network, conveying task relevant information at various time intervals during task processing (5, 6). First, during preparatory periods, ACC neurons convey signals selective for the currently relevant SR mapping rule (7), and allow inferences with respect to changes in SR mapping triggered by either an incorrect response, or an explicit cue to change SR mapping (8). Second, during stimulus processing and delay epochs in working memory paradigms, subsets of neurons encode the expected reward outcome associated with the stimulus (9). Third, following the behavioral response to a target stimulus, neuronal groups in ACC signal whether the behavioral response was incorrect or result...

show abstract

Anterior cingulate error‐related activity is modulated by predicted reward

Cited by 203 publications

References 26 publications

Frontal Cortex Subregions Play Distinct Roles in Choices between Actions and Stimuli

Frontal Cortex Subregions Play Distinct Roles in Choices between Actions and Stimuli

Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol

Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors

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